The immune response in individuals with hla-dr specificities conferring susceptibility to insulin-dependent diabetes - A hypothesis
The genetic control of insulin-dependent diabetes as well as of other autoimmune endocrine disorders have not been defined. These disorders are often said to run in families but the mode of inheritance is not understood. A most intriguing aspect of insulin-dependent diabetes is its close association with the HLA-DR specificities 3 and/or 4. More than 90% of all caucasian IDDM have either one or bo