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A comparison between flexible electrogoniometers, inclinometers and three-dimensional video analysis system for recording neck movement

This study compared neck range of movement recording using three different methods goniometers (EGM), inclinometers (INC) and a three-dimensional video analysis system (IMG) in simultaneous and synchronized data collection. Twelve females performed neck flexion-extension, lateral flexion, rotation and circumduction. The differences between EGM, INC, and IMG were calculated sample by sample. For fl

Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events

Background The ankle brachial index (ABI) is related to risk of cardiovascular events independent of the Framingham risk score (FRS). The aim of this study was to develop and evaluate a risk model for cardiovascular events incorporating the ABI and FRS. Design An analysis of participant data from 18 cohorts in which 24,375 men and 20,377 women free of coronary heart disease had ABI measured and w

Pharmacokinetics of Levodopa, Carbidopa, and 3-O-Methyldopa Following 16-hour Jejunal Infusion of Levodopa-Carbidopa Intestinal Gel in Advanced Parkinson's Disease Patients

Motor complications of Parkinson's disease (PD) are a consequence of pulsatile dopaminergic stimulation from standard oral levodopa therapy. Levodopa-carbidopa intestinal gel (LCIG) is infused continuously via an intrajejunal percutaneous gastrostomy tube. This was the first study designed to characterize the full pharmacokinetic profiles of levodopa, carbidopa, and levodopa metabolite, 3-O-methyl

Measurement of the cross section for diffractive deep-inelastic scattering with a leading proton at HERA

The cross section for the diffractive deep-inelastic scattering process ep -> eXp is measured, with the leading final state proton detected in the H1 Forward Proton Spectrometer. The data sample covers the range x(P) < 0.1 in fractional proton longitudinal momentum loss, 0.1 < vertical bar t vertical bar < 0.7 GeV2 in squared four-momentum transfer at the proton vertex and 4 < Q(2) < 700 GeV2 in p

Interaction between c-jun and Androgen Receptor Determines the Outcome of Taxane Therapy in Castration Resistant Prostate Cancer.

Taxane based chemotherapy is the standard of care treatment in castration resistant prostate cancer (CRPC). There is convincing evidence that taxane therapy affects androgen receptor (AR) but the exact mechanisms have to be further elucidated. Our studies identified c-jun as a crucial key player which interacts with AR and thus determines the outcome of the taxane therapy given. Docetaxel (Doc) an

Integrating climate change adaptation, disaster risk reduction and urban planning: A review of Nicaraguan policies and regulations

The integration of risk reduction and climate change adaptation has become an urgent task in addressing increasing urban risk more effectively and efficiently. This paper analyses the extent to which climate change adaptation is integrated into the policies and regulatory frameworks that guide urban risk reduction in Nicaragua, and discusses related progress. The results reveal significant progres

Using the Integration of Disparate Antecedents to Drive World-Class Innovation Performance: An Empirical Investigation of Swiss Watch Manufacturing Firms

Although organizational innovativeness has been regarded as propelling the market, entrepreneurial and learning orientation, as well as innovativeness relationships, much of the evidence to date remains anecdotal and speculative. In other words, little is known empirically about how these orientations contribute to a firm innovation. This leads to reductionism in modeling and thwarts the full expl

Modeling eye movements in visual agnosia with a saliency map approach: Bottom–up guidance or top–down strategy?

Two recent papers (Foulsham, Barton, Kingstone, Dewhurst, & Underwood, 2009; Mannan, Kennard, & Husain, 2009) report that neuropsychological patients with a profound object recognition problem (visual agnosic subjects) show differences from healthy observers in the way their eye movements are controlled when looking at images. The interpretation of these papers is that eye movements can be

Hygienization of sludge through anaerobic digestion at 35, 55 and 60 ºC

Legislation in Sweden and the European Union concerning the use of sewage sludge in agriculture is under revision and future concentration limits for pathogens in treated sludge are likely to be expected. The aim of this study was to evaluate the hygienization of Salmonella, Escherichia coli, Enterococcus and Clostridium perfringens through continuous anaerobic digestion at 35, 55 or 60 ºC as well

Gas turbine sensor validation through classification with artificial neural networks

Modern power plants are all strongly dependent on reliable and accurate sensor readings for monitoring and control, thus making sensors an important part of any plant. Failing sensors can force a plant or component into non-optimal operation, cause complete shut-down of operation or in the worst case result in damage to components. Given their importance, sensors need regular calibration and maint

Multi-Pitch Estimation

In this paper, we formulate the multi-pitch estimation problem and propose a number of methods to estimate the set of fundamental frequencies. The proposed methods, based on the nonlinear least-squares (NLS), Multiple Signal Classification (MUSIC) and the Capon principles, estimate the multiple fundamental frequencies via a number of one-dimensional searches. We also propose an iterative method ba

Noninvasive Imaging of Human Foveal Capillary Network Using Dual-Conjugate Adaptive Optics

PURPOSE. To demonstrate noninvasive imaging of human foveal capillary networks with a high-resolution, wide-field, dual-conjugate adaptive optics (DCAO) imaging instrument. METHODS. The foveal capillary networks of five healthy subjects with no previous history of ocular or neurologic disease or surgery were imaged with a novel high-resolution, wide-field DCAO instrument. The foveal avascular zone

Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens

Protection against mucosally transmitted infections probably requires immunity at the site of pathogen entry(1), yet there are no mucosal adjuvant formulations licensed for human use. Polyethyleneimine (PEI) represents a family of organic polycations used as nucleic acid transfection reagents in vitro and DNA vaccine delivery vehicles in vivo(2,3). Here we show that diverse PEI forms have potent m

Design of Low-Order Controllers using Optimization Techniques

In many applications, especially in the process industry, low-level controllers are the workhorses of the automated production lines. The aim of this study has been to provide simple tuning procedures, either optimization-based methods or tuning rules, for design of low-order controllers. The first part of this thesis deals with PID tuning. Design methods or both SISO and MIMO PID controllers bas

Electron spectroscopy of rare-gas clusters irradiated by x-ray free-electron laser pulses from SACLA

We have measured electron energy spectra and asymmetry parameters of Ar clusters and Xe clusters illuminated by intense x-rays at 5 and 5.5 keV. A velocity map imaging spectrometer was developed for this purpose and employed at an x-ray free-electron laser facility, SACLA in Japan. The cluster size dependence and the peak fluence dependence of the electron spectra and asymmetry parameters are disc

Associations of type 2 diabetes mellitus with cancer and autoimmune diseases. A population-based epidemiological study in Sweden.

This thesis aimed to search for epidemiological evidence supporting the associations of type 2 diabetes mellitus (T2DM) with cancer and autoimmune diseases (ADs) by analysing several Swedish national registries. T2DM shares risk factors with cancer, such as obesity, diet, stress, and physical inactivity. However, it is unclear whether the associations with several types of cancers are due to share

The Political Foundations of Trust and Distrust: Reforms and Protests in France

This article argues that the high level of protest activity in France is, at least partly, the result of distrust between the government and the trade unions, and that such distrust is inevitable in a society where unions are sometimes strong enough to mobilise against the government but not confident in their own future strength. This trust problem can be overcome if governments are willing to ma