Multiple analogs of parathyroid hormone, all of which bind to the PTH/PTHrP receptor PTH1R, are used for patients with osteoporosis and hypoparathyroidism. Although ligands such as abaloparatide, teriparatide (hPTH 1-34 [TPTD]), and long-acting PTH (LA-PTH) show distinct biologic effects with respect to skeletal and mineral metabolism endpoints, the mechanistic basis for these clinically-important

Graves’ disease (GD) is an autoimmune disease characterized by hyperthyroidism and is caused by an interplayof genetic and environmental factors. One-third of patients with GD develop Graves’ ophthalmopathy (GO). Keyprocesses in the pathogenesis of GO are inflammation and adipogenesis in orbital tissue. Strong risk factorsassociated with the development of GO are smoking and radioiodine treatment

We use direct N-body simulations to explore some possible scenarios for the future evolution of two massive clusters observed towards the centre of NGC 4654, a spiral galaxy with mass similar to that of the Milky Way. Using archival HST data, we obtain the photometric masses of the two clusters, M = 3 × 105 M= and M = 1.7 × 106 M=, their half-light radii, Reff ∼4 pc and Reff ∼6 pc, and their proje

To improve communication during emergencies, this research introduces an agent-based modeling (ABM) method to test the effect of psychological emergency communication strategies on evacuation performance. We follow a generative social science approach in which agent-based simulations allow for testing different candidate solutions. Unlike traditional methods, such as laboratory experiments and fie

Colorectal cancer (CRC) is the second most common cancer in women and third most common cancer in men worldwide. The cause of the majority of death related to CRC is believed to be the migration of cancer cells to distant organs which is known as cancer metastasis. The mechanism behind cancer cell metastasis is not fully understood but accumulating studies suggest that it could be due to enhanced

In this chapter, the author argues that there are cases in which a nonexpert’s autonomously-formed belief is based on evidence that would otherwise be sufficient for justification, but where this belief is rendered unjustified by (potential) evidence which the nonexpert fails to take into account. He gives various examples in support of his claim. One involves Roger, a food scientist for a large f

The term hypothesis denotes something like a policy proposal rather than a factual claim. An organisational tool stands a greater chance of success if it is easy and fun to work with. Better Beliefs represents the current credibility status of hypotheses using the amusing analogy with a horse race, each horse representing a hypothesis. The colour of a horse depends on the votes and evidence provid

Flaps are widely used in oculoplastic reconstructive surgery to cover defects following the removal of tumors, malformations, or trauma. Adequate blood perfusion of the flap is crucial for its survival. Knowledge about the perfusion in different type of flaps is therefore of great value. The main aim of the studies presented in this thesis was to investigate the changes in blood perfusion in advan

Overexpression of the receptor tyrosine kinase MET has been linked to poor survival in several cancer types, and MET has been suggested to interact with stem cell networks. In vitro studies have further suggested a possible benefit of a combined treatment using PARP and MET inhibitors. We used a tissue microarray (TMA) with 130 samples of advanced-stage high-grade serous fallopian tube/ovarian can

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The article looks into the multicultural settings of Liviu Rebreanu’s novel “Amândoi” (Both) by briefly examining the representation of its main, minor or incidental characters, either intelligentsia or common people. Ethnicity, social and professional statuses are considered as elements of multiculturalism. The continuous increase of suspense, the open ending, the parody in the undertone, and the

Internet-of-Things (IoT) systems consist of spatially distributed interacting devices. In contrast to desktop applications, IoT systems are always running and need to deal with unresponsive devices and weak connectivity. In this thesis, we propose techniques for simplifying the development of such systems. The work addresses IoT systems organised as reusable services connected by compositions. We

This paper examines the Swedish record of competition in the supply of bank notes in the 19th century. Between 1831 and 1902, private commercial banks, organized as partnerships with unlimited liability for their owners, issued notes competing with the notes of the Riksbank, the bank owned by the Riksdag, the Swedish parliament. The private banks turned out to be competitive in this market despite

We study the origins of support for gender-related affirmative action (AA) in two pre-registered online experiments (N = 1, 700). Participants act as employers who decide whether to use AA in hiring job candidates. We implement three treatments to disentangle the preference for AA stemming from i) perceived gender differences in productivity, ii) beliefs about AA effects on productivity, or iii) ot

A recent study proposed by Westerlund (CCE in Panels with General Unknown Factors, Econometrics Journal, 21, 264-276, 2018) showed that a very popular Common Correlated Effects (CCE) estimator is significantly more applicable than it was thought before. Contrary to the usual stationarity assumption, common factors can in fact be much more general and not unit root only. This also helps to alleviat

Gender intersects as a major fault-line in increasingly polarized, contemporary global politics. Many democratic states in the global North and South have adopted pro-gender norms in their foreign policies, while other states and populist regimes have resisted the promotion of gender equality and women's rights. This article analyses how political leaders harness gender dynamics to further their p

S1P (Sphingosine-1-phosphate) is an important regulator of immune cell trafficking and vascular dysfunction contributing to the development and progression of overt hypertension. Although targeting S1P signaling revealed therapeutic potential in different experimental hypertension studies, validations of S1P-blood pressure (BP) associations in humans are lacking. In a translational approach, we ex

BACKGROUND: Due to demographic changes, hospital emergency departments in many countries are overcrowded. Internationally, several primary healthcare models have been introduced as alternatives to hospitalisation. In Norway, municipal acute wards (MAWs) have been implemented as primary care wards that provide observation and medical treatment for 24 h. The intention is to replace hospitalisation f