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Relational venture capital financing of serial founders

I study how often and why a serial founder receives financing for his new company from a venture capital (VC) firm that also invested in his previous company. One in 10 VC investments leads to a repeated relationship and one in three serial founders enters into a repeated relationship with any previous VC firm. A repeated relationship is more likely when the relational VC firm has acquired more pr

The uncertain climate footprint of wetlands under human pressure

Significant climate risks are associated with a positive carbon-temperature feedback in northern latitude carbon-rich ecosystems, making an accurate analysis of human impacts on the net greenhouse gas balance of wetlands a priority. Here, we provide a coherent assessment of the climate footprint of a network of wetland sites based on simultaneous and quasi-continuous ecosystem observations of CO2

The legitimacy of incentive-based conservation and a critical account of social safeguards.

Incentive-based conservation has become a significant part of how tropical forests are being governed. Reducing emissions from deforestation and forest degradation (REDD+) is a mechanism to mitigate climate change that many countries have started to implement. REDD+, however, is criticized for its potential negative impacts on local populations and Indigenous people. To prevent and mitigate the ne

Noradrenaline neuron degeneration contributes to motor impairments and development of L-DOPA-induced dyskinesia in a rat model of Parkinson's disease.

Parkinson's disease (PD) is characterized by progressive loss of dopaminergic (DA) neurons in the substantia nigra. However, studies of post-mortem PD brains have shown that not only DA neurons but also the noradrenergic (NA) neurons in the locus coeruleus degenerate, and that the NA neurodegeneration may be as profound, and also precede degeneration of the midbrain DA neurons. Previous studies in

Reoptimization of Dynamic Flexgrid Optical Networks After Link Failure Repairs

In dynamic flexgrid optical networks, the usage of capacity may not be optimal due to the permanent process of setting up and tearing down connections, which, if not controlled, leads to spectrum fragmentation and, as a result, to increase of connection blocking. On top of this, a restoration mechanism that is launched in reaction to a link failure (cable cut) restores the affected lightpaths. Eve

Heavy chains of inter alpha inhibitor (IαI) inhibit the human complement system at early stages of the cascade .

Inter alpha inhibitor (IαI) is an abundant serum protein consisting of three polypeptides: two heavy chains (HC1 and HC2) and bikunin, a broad-specificity Kunitz-type proteinase inhibitor. The complex is covalently held together by chondroitin sulphate but during inflammation IαI may interact with TNF-stimulated gene 6 protein (TSG-6), which supports transesterification of heavy chains to hyaluron

Validity, reliability, and responsiveness of the Self-reported Foot and Ankle Score (SEFAS) in forefoot, hindfoot, and ankle disorders.

Background and purpose - The self-reported foot and ankle score (SEFAS) is a questionnaire designed to evaluate disorders of the foot and ankle, but it is only validated for arthritis in the ankle. We validated SEFAS in patients with forefoot, midfoot, hindfoot, and ankle disorders. Patients and methods - 118 patients with forefoot disorders and 106 patients with hindfoot or ankle disorders comple

No title

As a consequence of the municipality reform and the consequent move of services from hospital to primary healthcare, a Danish municipal wished to strengthen the professional competences, fellow-feeling, and collegiate spirit of their community nurses, taking their starting point in their newly developed ‘profile for community nurses’. This article presents a concept for reflection on practice whic

Archeological excavation monitoring using dense stereo matching techniques

Several new tools to obtain three-dimensional information from unorganized image sets are now available for the public use. The main advantage of this software, which is based on dense stereo matching, is the possibility to generate 3D content without the need of high-cost hardware (e.g. 3D scanning devices). Nevertheless, their use in real-world application domains (like cultural heritage) is st

Differential aetiology and impact of phosphoinositide 3-kinase (PI3K) and Akt signalling in skeletal muscle on in vivo insulin action

Aims/hypothesis Insulin resistance in skeletal muscle is a key factor in the development of type 2 diabetes and although some studies indicate that this could be partly attributed to reduced content and activity of various proximal and distal insulin signalling molecules, consensus is lacking. We therefore aimed to investigate the regulation of proximal insulin signalling in skeletal muscle and it

The productivity, allocation and cycling of carbon in forests at the dry margin of the Amazon forest in Bolivia

Background: The dry transitional forests of the southern Amazonia have received little attention from a carbon cycling and ecosystem function perspective, yet they represent ecosystems that may be impacted by global climate change in the future. Aims: To compare the full carbon cycle for two 1-ha forest plots that straddle the ecotone between humid forest and dry forest in Amazonia, ca. 100 km fro

Injection and transport properties of fast electrons in ultraintense laser-solid interactions

Fast electron injection and transport in solid foils irradiated by sub-picosecond-duration laser pulses with peak intensity equal to 4 x 10(20)W/cm(2) is investigated experimentally and via 3D simulations. The simulations are performed using a hybrid-particle-in-cell (PIC) code for a range of fast electron beam injection conditions, with and without inclusion of self-generated resistive magnetic f

In situ determination of N-2 broadening coefficients in flames for rotational CARS thermometry

Total N-2 S-branch broadening coefficients have been measured in situ as a function of radial position in a highly sooting ethylene diffusion flame by the use of time-resolved dual-broadband picosecond pure rotational CARS (RCARS). Time-domain measurements of the J-dependent N-2 rotational coherence decays in the flame were used to determine the broadening coefficients, and these coefficients were

Urostomy and health-related quality of life in patients with lower urinary tract dysfunction

Objective. Urinary diversion may be an option in patients with disabling lower urinary tract dysfunction (DLUTD), refractory to conservative and minor invasive treatment. The aim of this study was to evaluate whether urostomy improves quality of life and cost of surgery, in terms of complications, loss of kidney function and hospital stay, in these patients. Material and methods. This prospective

Pion, Kaon, and Proton Production in Central Pb-Pb Collisions at root s(NN)=2.76 TeV

In this Letter we report the first results on pi(+/-), K-+/-, p, and (p) over bar production at midrapidity (vertical bar y vertical bar < 0.5) in central Pb-Pb collisions at root s(NN) = 2.76 TeV, measured by the ALICE experiment at the LHC. The p(T) distributions and yields are compared to previous results at root s(NN) = 200 GeV and expectations from hydrodynamic and thermal models. The spectra

Quantification of microscopic diffusion anisotropy disentangles effects of orientation dispersion from microstructure: Applications in healthy volunteers and in brain tumors

The anisotropy of water diffusion in brain tissue is affected by both disease and development. This change can be detected using diffusion MRI and is often quantified by the fractional anisotropy (FA) derived from diffusion tensor imaging (DTI). Although FA is sensitive to anisotropic cell structures, such as axons, it is also sensitive to their orientation dispersion. This is a major limitation t

Interference effects in two-color high-order harmonic generation

We study high-order harmonic generation in argon driven by an intense 800 nm laser field and a small fraction of its second harmonic. The intensity and divergence of the emitted even and odd harmonics are strongly modulated as a function of the relative delay between the two fields. We provide a detailed analysis of the underlying interference effects. The interference changes drastically when app