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Lipid nanoparticles (LNPs) are clinically approved for mRNA-based vaccines and liver-targeted siRNA delivery. However, poor nucleic acid delivery efficiency limits their application in extrahepatic tissues and tumors. Here, using live-cell and super-resolution microscopy, we identify multiple distinct steps of inefficiencies in the cytosolic delivery of both siRNA and mRNA cargoes. Membrane damage
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This article probes the writings of the Jewish Trotskyist thinker Daniel Bensaïd (1946–2010) in light of recent debates on political theology. In contrast to what is sometimes explicitly referred to as ‘apocalyptic political theology’, it makes a case for what may be described as a ‘prophetic political theology’. Yet it is not obvious to claim Bensaïd as a proponent for such a project, since he ex
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Global change is altering forests worldwide, with multiple consequences for ecosystem functioning. Temporal changes in climate, and extreme, compounded weather events like hotter droughts are affecting the demography, composition and function of forests, leading to a highly uncertain future. To accurately predict future forest responses to hotter droughts, we highlight the need for considering a b
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Utvärderingen visar att ersättningar för att sköta betesmarker och slåtterängar har en positiv men begränsad effekt på biologisk mångfald i form av fågelfauna och en sammansatt landskapsindikator. Andra stöd och ersättningar som utvärderades har mindre betydelse för dessa indikatorer. Utvärderingen poängterar dock behovet av förbättrad övervakning och data som möjliggör mer detaljerade utvärderingWe have evaluated the impact of the Rural Development Programme 2014–2022 and its support of measures benefitting biodiversity. Bird population sizes, using the Farmland Bird Index (FBI), serve as the main indicator of biodiversity, but the High Nature Value Farmland (HNV) indicator is also used. Our conclusions are:• A combination of approaches is required to evaluate the effects of agrienvironme