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Blood-based biomarkers hold great promise to revolutionize the diagnostic and prognostic work-up of Alzheimer’s disease (AD) in clinical practice. This is very timely, considering the recent development of anti-amyloid-β (Aβ) immunotherapies. Several assays for measuring phosphorylated tau (p-tau) in plasma exhibit high diagnostic accuracy in distinguishing AD from all other neurodegenerative dise
This conceptual article contributes to the post-growth strand of political ecology literature, which seeks to find sustainable ways of organizing the economy that do not require economic growth. It explores the idea that transitioning to post-growth societies requires a transition in the relationship-to-profit of business. I first conceptualize relationship-to-profit as the intersection of purpose
Purpose: Patients with persistent or recurrent papillary and poorly differentiated thyroid cancer can be effectively treated with radioiodine, if the tumour tissue is iodine-avid. However, iodine-avidity status is often unknown at the time of initial radioiodine treatment, limiting any adaptive approach. This study aimed to clarify the relationship between pre-therapeutic iodine avidity in primary
Background: The purpose of this paper is to explore the underlying challenges in the telehealth environment in India and Pakistan that impede the delivery of high-quality images between a patient and health care professional.Method: An exploratory study was conducted among healthcare professionals in India and Pakistan to assess their perceptions regarding image quality, which is used for the diag
Aims/hypothesis: Low birthweight is a risk factor for type 2 diabetes but it is unknown whether low birthweight is associated with distinct clinical characteristics at disease onset. We examined whether a lower or higher birthweight in type 2 diabetes is associated with clinically relevant characteristics at disease onset. Methods: Midwife records were traced for 6866 individuals with type 2 diabe
Organisms modify their development and function in response to the environment. At the same time, the environment is modified by the activities of the organism. Despite the ubiquity of such dynamical interactions in nature, it remains challenging to develop models that accurately represent them, and that can be fitted using data. These features are desirable when modeling phenomena such as phenoty
During the ongoing multi-country monkeypox (Mpox) outbreak, healthcare workers (HCWs) have represented a key group in mitigating disease spread. The current study aimed to evaluate the attitude of nurses and physicians in Jordan towards Mpox vaccination, as well as their attitude towards compulsory vaccination against coronavirus disease 2019 (COVID-19), influenza, and Mpox. An online survey was d
The Planetary Boundaries concept (PBc) has emerged as a key global sustainabilityconcept in international sustainable development arenas. Initially presented as an agenda for globalsustainability research, it now shows potential for sustainability governance.Weuse the fact that it iswidely cited in scientific literature (>3500 citations) and an extensively studied concept to analyse howit has been
Background: Life's Simple 7 (LS7) aims to promote ideal cardiovascular health (CVH). Its association with different cognitive states in the older old is unclear. Objectives: To assess the associations of LS7 with transitions across normal cognition, cognitive impairment, no dementia (CIND), and dementia and evaluate cognitive impairment-free years of life by LS7-defined CVH levels in older adults.
At the heart of the failing growth-based, capitalist system is the ‘for-profit’ way of doing business. It is based on the idea that humans are mostly selfish and competitive, so the best way to motivate economic activity is to appeal to individual self-interest. Most approaches to resolve capitalism’s tendency to increasingly create socioeconomic inequality and ecological devastation entail either
It is well known that computer vision can be unreliable when faced with previously unseen imaging conditions. This paper proposes a method to adapt camera parameters according to a normalizing flow-based out-of-distibution detector. A small-scale study is conducted which shows that adapting camera parameters according to this out-of-distibution detector leads to an average increase of 3 to 4% poin
Background: Multidisciplinary team meetings (MDTMs) provide an integrated team approach to ensure individualized and evidence-based treatment recommendations and best expert advice in cancer care. A growing number of patients and more complex treatment options challenge MDTM resources and evoke needs for case prioritization. In this process, decision aids could provide streamlining and standardize
The rapidly evolving domain of network systems poses complex challenges, especially when considering scalability and transient behaviors. This thesis aims to address these challenges by offering insights into the transient analysis and control design tailored for large-scale network systems. The thesis consists of three papers, each of which contributes to the overarching goal of this work.The fir
I 1220 ville den svenske konge gøre Valdemar Sejr kunsten efter og erobre land med et korstog i Baltikum. Det gik ikke godt.
Increasingly stringent pollutant and CO2 emission standards require the car manufacturers to investigate innovative solutions to further improve the fuel economy and environmental impact of their fleets. Nowadays, NOx emissions standards are stringent for spark-ignition (SI) internal combustion engines (ICEs) and many techniques are investigated to limit these emissions. Among these, an extremely
A critical book review of Osagie Obasogie's book Blinded by Sight: Seeing Race through the Eyes of the Blind discussed its methodological, analytical, and theoretical choices whilst also analyzing its relevance in a contemporary setting.
