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The human proto-oncogene INT2 (homologous to the mouse INT2 gene, implicated in proviral induced mammary carcinoma) has been mapped to chromosome llql3 and found to share band localisation with, among others, the HST1 proto-oncogene. Both genes are members of the fibroblast growth factor family. In the present study, coamplification (2-15 copies) of the INT2/HST1 genes was found in 27 (9%) of 311

Recent studies on breast cancer risk factors suggest that nursing may have a protective effect. The mechanism behind this is unknown. To investigate whether removal of tumorigenic epithelial cells in breast milk contributes to the reduced risk of developing breast cancer, DNA ploidy of cells in colostrum breast milk from 200 primiparous women was studied with flow cytometry. No woman displayed an

In previous studies in southern Sweden, early use of oral contraceptives has been found to be accompanied by an increased risk of developing premenopausal breast cancer, and the tumors developing in these patients have shown a more aggressive behavior. In the present study, amplification of the proto-oncogenes Her-2/neu (also known as ERBB2) and INT2 was studied in primary tumor specimens from 72

In general, findings in studies on oral contraceptives (OCs) and breast cancer have not indicated prognosis to be worse among users of OCs. In few studies, however, has age at the start of OC usage been considered as a prognostic factor. In the present study prognosis in breast cancer is compared with OC usage particularly with age at the start of OC usage among 193 consecutive patients at the Dep

In southern Sweden, extensive oral contraceptive use (OC use) among young women was a reality during the 1960s, thus making our region especially suited for studies investigating the hypothesis that early OC use is associated with the development of premenopausal breast cancer after a possible latency time between the exposure and the disease. The results of this study revealed that the risk of de

The presence of neuroendocrine differentiation, as expressed by cellular chromogranin immunoreactivity, was investigated in paraffin‐embedded tissue material from 51 consecutive cases of male breast carcinoma. From six of these cases electron microscopic studies were included. Chromogranin‐immunoreactive cells were present in solid cords and delineated tubular structures. Ultrastructurally, dense

The development of human breast cancer is characterized by a variety of genetic alterations, and cytogenetic analyses have documented the consistent involvement of both arms of chromosome I. In the present study, molecular markers detecting restriction fragment length polymorphisms were used in pairwise screening of normal and tumor DNA to determine the frequency of allelic imbalance in breast tum

Using a self-report questionnaire, the Hospital Anxiety and Depression (HAD) scale, feelings of anxiety and depression were assessed in 133 breast cancer patients referred for adjuvant radiotherapy following surgical treatment. Eighteen patients (14% had scores indicating morbid anxiety. Significant depression was recorded for only 2 patients (1.5% Severe anxiety was recorded for 10 out of 54 mast

Southern travelling habits were recorded for 127 melanoma patients from southern parts of Sweden (the 56th latitude), 55 thyroid cancer patients, 100 non-Hodgkin's patients and 794 healthy controls from the same region. Melanoma patients were found to travel significantly more often south of the 45th latitude, as compared with patients with non-Hodgkin's lymphoma or thyroid carcinoma (RR = 2.2 for

The significance of the retinoblastoma gene (RB) in the development of human breast cancer remains unclear. In the present study, loss of heterozygosity (LOH) in RB was found in 26% of 90 informative primary breast tumors and was correlated to DNA nondiploidy, a high S-phase fraction, and LOH at chromosome 17pl33. However, allele loss was not associated with loss of RB protein (pRB) expression. Lo

Denna artikel undersöker vilken betydelse och potential som begreppet musikalitet kan ha för skådespelares lärprocesser. Studien riktar sig främst till lärare och forskare vid landets högre konstnärliga utbildningar. Betraktad som professionsforskning och som exempel på språkliga metaforers potential i konceptualiserings- och lärandeprocesser bör den emellertid kunna vara av intresse även för andr

Fundamental bounds on antenna gain are found via convex optimization of the current density in a prescribed region. Various constraints are considered, including self-resonance and only partial control of the current distribution. Derived formulas are valid for arbitrarily shaped radiators of a given conductivity. All the optimization tasks are reduced to eigenvalue problems, which are solved effi

Meniscal extrusion (ME) in the knee joint is defined as when the peripheral border of the meniscus is substantially located outside the joint margin. Prior studies have reported that ME is associated with meniscal tears, meniscal degeneration, and the presence of knee osteoarthritis (OA). Medial ME of the body of 3 mm or more, as seen on knee Magnetic Resonance Imaging (MRI) has a wide acceptance

This paper presents the results from two studies on anaphoric reference to quantifying expressions (QEs) in Swedish, contributing to the current cross-linguistic discussion on this issue. For English it has been shown that the polarity of the QE (positive vs negative) determines the anaphoric set reference (to the referens set, REFSET, or to the complement set, COMPSET), while for Spanish it has b

This article examines challenges to the classical paradigm of education in Sweden that followed in the wake of state-initiated attempts at school reform in the first decades of the nineteenth century. When the internal disputes of the so-called ‘Genius Committee’ resulted in a failure to overcome the increasing divide between reformers, a prolific opportunity to argue the value of practical subjec

De litterära karaktärerna är väsentliga för om läsarna ska engagera sig i en text och uppleva den som intressant och meningsfull, antingen man skapar egna karaktärer eller skriver fanfiction och diktar vidare på karaktärer som andra författare byggt upp. Gestaltningen är central och många unga ägnar sig åt att dikta vidare på kända verk, något som väcker frågan om vem som ”äger” de fiktiva karaktä

This Letter presents a search for heavy charged long-lived particles produced in proton–proton collisions at s=13TeV at the LHC using a data sample corresponding to an integrated luminosity of 36.1fb−1 collected by the ATLAS experiment in 2015 and 2016. These particles are expected to travel with a velocity significantly below the speed of light, and therefore have a specific ionisation higher tha