l-DOPA is the most commonly used treatment for symptomatic control in patients with Parkinson's disease. Unfortunately, most patients develop severe side-effects, such as dyskinesia, upon chronic l-DOPA treatment. The patophysiology of dyskinesia is unclear; however, involvement of serotonergic nerve fibers in converting l-DOPA to dopamine has been suggested. Therefore, potassium-evoked dopamine r

The hydrological sensitivities to long-term climate change of a watershed in Eastern Canada were analysed using a deterministic watershed runoff model developed to simulate watershed acidification. This model was modified to study atmospheric change effects in the watershed. Water balance modelling techniques, modified for assessing climate effects, were developed and tested for a watershed using

Activation of the beta-receptor for platelet-derived growth factor (PDGF) by its ligand leads to autophosphorylation on a number of tyrosine residues. Here we show that Tyr763 in the kinase insert region is a novel autophosphorylation site, which after phosphorylation binds the protein tyrosine phosphatase SHP-2. SHP-2 has also previously been shown to bind to phosphorylated Tyr1009 in the PDGF be

Mass, heat and momentum transport processes are strongly coupled with catalytic chemical reactions in a methane steam reforming duct. In this paper, a three-dimensional calculation method is developed to simulate and analyze reforming reactions of methane, and the effects on various transport processes in a steam reforming duct. The results show that the design and operating parameters grouped as

Background. Allergy nurses are exposed to allergens and respiratory irritants, and there are no national guidelines addressing personnel safety when working with these agents. Objective. To investigate the prevalence of allergies, asthma, and hypersensitivity symptoms among allergy nurses and the use of protective equipment and measures when working with allergen concentrates and respiratory irrit

Artikel gällande handläggning av yrsel på akutmottagningen.The majority of patients who present to the Emergency Department with vertigo suffer from benign conditions. However, a few percent of these patients have life-threatening conditions, such as a cerebellar stroke. The HINTS clinical decision rule (Head-Impulse test, Nystagmus, Test-of-Skew) allows the physician to identify patients with an acute vestibular syndrome of central origin. HINTS is more

Radio-frequency identification (RFID) with a received signal strength indicator (RSSI) is a low-cost and low-complexity approach for item-level indoor localization. Although RSSI-based algorithms suffer from multipath effect and other environmental factors, reference tags and RSSI changes can be utilized to further improve the localization accuracy. However, the current algorithms lack deep analys

Objective: The etiology of abdominal aortic aneurysm (AAA) includes atherosclerotic, inflammatory, immunological and coagulatory mechanisms. The aim of this study was to evaluate associations between markers for some of these mechanisms and AAA-size, in order to identify markers which might later be evaluated in relation to aneurysm growth. Material and methods: Prospectively 360 AAA-patients and

The conversion of the β-amyloid (Aβ) peptide into pathogenic aggregates is linked to the onset and progression of Alzheimer's disease. Although this observation has prompted an extensive search for therapeutic agents to modulate the concentration of Aβ or inhibit its aggregation, all clinical trials with these objectives have so far failed, at least in part because of a lack of understanding of th

We present a new duplex scheme, called Zipper, for discrete multitone (DMT)-based very high bit-rate digital subscriber line (VDSL) systems on copper wires. This scheme divides the available bandwidth by assigning different subcarriers for the upstream and downstream directions. It has high flexibility to divide the capacity between the up and downstream, as well as good coexistence possibilities