The tissue distribution and prognostic relevance of subtype-specific proteins (ASCL1, NEUROD1, POU2F3, YAP1) present an evolving area of research in small-cell lung cancer (SCLC). The expression of subtype-specific transcription factors and P53 and RB1 proteins were measured by immunohistochemistry (IHC) in 386 surgically resected SCLC samples. Correlations between subtype-specific proteins and in

Objective: To examine potential genetic relationships between migraine and the two distinct phenotypes posterior circulation ischemic stroke (PCiS) and anterior circulation ischemic stroke (ACiS), we generated migraine polygenic risk scores (PRSs) and compared these between PCiS and ACiS, and separately vs. non-stroke control subjects. Methods: Acute ischemic stroke cases were classified as PCiS o

The electrostatic interactions between cationic poly(amidoamine) (PAMAM) dendrimers of different generations, G3, G4, and G6, with net anionic model biomembranes have been predicted by adopting an analytical model based on two dissimilar soft spheres. The influence of bilayer surface charge density, ionic strength, pH, temperature, membrane softness (modeled as changes in bilayer thickness), and d

Bicycling is an important form of active transport that contributes to sustainability mobility as a result of its role in personal and public health and emissions reduction. The significance of which has grown since the COVID-19 pandemic outbreak. However, biking studies have neglected, in theoretical terms, developing an understanding of why consumers bike. Therefore, this research designs and ve

The paper aims to address how ethics plays an important role in understanding the entrepreneur as an experiencing agent throughout the entrepreneurial process. Drawing from normative ethics, we conceptualize an opportunity process model that posits the entrepreneur as a moral agent who acts in an ethical manner from the intention to identify an opportunity, through the entrepreneurial actions take

Sustainability is an increasingly important topic across the world, and awareness of it has been growing since the publication of the UN sustainable development goals (SDGs). Seeing an escalating societal interest in sustainability, consumer demand for sustainable products in retailer’s assortments. Making the retail store manager a key player for implementing Corporate Social Responsibility (CSR)Sustainability is an increasingly important topic across the world, and awareness of it has been growing since the publication of the UN sustainable development goals (SDGs). Seeing an escalating societal interest in sustainability, consumer demand for sustainable products in retailer’s assortments. Making the retail store manager a key player for implementing Corporate Social Responsibility (CSR)

This chapter shows that war-making and peace-making “take place” and that sometimes the legacy of conflict obscures manifestations of peacebuilding. The analysis of a “bridge that divides” in the city of Mitrovica in northern Kosovo and a “wall that unites” in Belfast, Northern Ireland, casts light on the benefits that a spatial reading of peace can provide to understand the ways in which spatial

The AI landscape demands a broad set of legal, ethical, and societal considerations to be accounted for in order to develop ethical AI (eAI) solutions which sustain human values and rights. Currently, a variety of guidelines and a handful of niche tools exist to account for and tackle individual challenges. However, it is also well established that many organizations face practical challenges in n

Explicit embedding methods combined with the complex polarization propagator (CPP) enable the modeling of spectroscopy for increasingly complex systems with a high density of states. We present the first derivation and implementation of the CPP in four- and exact-two-component (X2C) polarizable embedding (PE) frameworks. We denote the developed methods PE-4c-CPP and PE-X2C-CPP, respectively. We il

Background: Sexual harassment (SH) has been highlighted as an important determinant for mental health. The aims of this study were to describe SH in terms of cumulative 1-year incidence, exposed groups, types of perpetrators and settings, and to measure the association between SH and poor mental well-being. Methods: Data from two waves of the Scania Public Health Cohort Study, comprising 7759 rand

Historiskt sett är religionsfrihet ett radikalare koncept än de flesta svenskar inser. Nu höjs röster om att upphäva den. Riskerar vi en ny intolerans? Det menar Jacob Rudenstrand.

Denna övningsbok följer upplägget i faktaboken Redovisning – från bokföring till analys. Övningsboken innehåller ett stort antal övningar med fullständiga lösningsförslag. Lösningarna kompletteras med utförliga kommentarer och förklaringar.Redovisning är en process som omfattar allt från företagets transaktioner och omständigheter, till den analys och användning av företagets redovisningsinformati

Free-energy calculations are crucial for investigating biomolecular interactions. However, in theoretical studies, the neglect of electronic polarization can reduce predictive capabilities, specifically for free-energy calculations. To effectively mimick polarization, we explore a Charge Switching (CS) model, aiming to narrow the gap between computational and experimental results. The model requir

Kinetic modeling could be viewed as an important step in developing a bioprocess, since models can be used in process control, reducing costs and optimizing processes. In the present study, the application of kinetic models in dark fermentative hydrogen production has been investigated. A wide variety of kinetic models are addressed and compared regarding their accuracy to fit the data. This liter

Background: Sick leave due to stress-related mental ill health increases in society. In occupational therapy, occupational balance is considered important for experiencing health and well-being. Thus, knowledge regarding occupational balance and occupational value constitute essential parts of occupational therapists’ work with people suffering from occupational ill health. Objective: The aim of t

Diareno[a,e]cyclooctatetraenes find widespread applications as building blocks, ligands, and responsive cores in topologically switchable materials. However, current synthetic methods to these structures suffer from low yields or operational disadvantages. Here, we describe a practical three-step approach to diareno[a,e]cyclooctatetraenes using an efficient copper(I) catalyzed double decarboxylati

Quarantine hotels have been established by governments to accommodate COVID-19 infected or potentially infectious guests. The employees of these hotels, despite the high-risk environment, must provide services to guests. However, limited research is conducted on the impacts of the pandemic on their psychological well-being and health. This study investigates the protection motivation of quarantine

In this letter, we deal with evolutionary game-theoretic learning processes for population games on networks with dynamically evolving communities. Specifically, we propose a novel mathematical framework in which a deterministic, continuous-time replicator equation on a community network is coupled with a closed dynamic flow process between communities, in turn governed by an environmental feedbac