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Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of Parkinson’s disease RESEARCH Open Access Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of Parkinson’s disease Anna Tamburrino1, Madeline J. Churchill2, Oi W. Wan3, Yolanda Colino-Sanguino3, Rossana Ippolito1, Sofie Bergstrand1, Daniel A. Wolf3, Niculin J. Herz4,

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_acta_neuropathol_commun.pdf - 2025-12-20

awr149 1..10 BRAIN A JOURNAL OF NEUROLOGY GDNF fails to exert neuroprotection in a rat a-synuclein model of Parkinson’s disease Mickael Decressac,1 Ayse Ulusoy,2,* Bengt Mattsson,1 Biljana Georgievska,1,† Marina Romero-Ramos,2,z Deniz Kirik2 and Anders Björklund1 1 Wallenberg Neuroscience Centre, Sölvegatan 17, 221 84 Lund, Sweden 2 Department of Experimental Medical Sciences, Brain Repair and I

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_brain_0.pdf - 2025-12-20

OP-BRAI140413 1..11 Eltoprazine counteracts L-DOPA-induced dyskinesias in Parkinson’s disease: a dose-finding study Per Svenningsson,1 Carl Rosenblad,2 Karolina af Edholm Arvidsson,1 Klas Wictorin,2 Charlotte Keywood,3 Bavani Shankar,4 David A Lowe,4 Anders Björklund5 and Håkan Widner2 See Bezard and Carta for a scientific commentary on this article (doi:10.1093/brain/awu407). In advanced stages

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_brain_a_journal_of_neurology.pdf - 2025-12-20

From Skin to Brain: A Parkinson’...s Own Cells | Elsevier Enhanced Reader 16/08/2020 From Skin to Brain: A Parkinson’s Disease Patient Transplanted with His Own Cells | Elsevier Enhanced Reader https://reader.elsevier.com/reader/sd/pii/S1934590920302757?token=18E0986632EFE43FDEBD61C1E1A53BA2E08480D5DA407F43F9E90D4FF675CCD08… 1/3 16/08/2020 From Skin to Brain: A Parkinson’s Dis

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_cellstemcell.pdf - 2025-12-20

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_exp_neurol.pdf - 2025-12-20

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_experimental_neurology.pdf - 2025-12-20

Comparison of the behavioural and histological characteristics of the 6-OHDA and α-synuclein rat models of Parkinson's disease Experimental Neurology xxx (2012) xxx–xxx YEXNR-11083; No. of pages: 10; 4C: 4, 5, 6, 9 Contents lists available at SciVerse ScienceDirect Experimental Neurology j ourna l homepage: www.e lsev ie r .com/ locate /yexnr Comparison of the behavioural and histological characte

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_experimental_neurology_1.pdf - 2025-12-20

fncel-14-00146.pdf REVIEW published: 29 May 2020 doi: 10.3389/fncel.2020.00146 Edited by: Sofia Grade, Institute of Molecular Biotechnology (OeAW), Austria Reviewed by: Daniel Tornero, University of Barcelona, Spain Afsaneh Gaillard, University of Poitiers, France *Correspondence: Anders Björklund anders.bjorklund@med.lu.se Specialty section: This article was submitted to Cellular Neuropathology,

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_frontiers_0.pdf - 2025-12-20

Journal of Parkinson’s Disease 9 (2019) 17–29 DOI 10.3233/JPD-181525 IOS Press 17 Review The Amphetamine Induced Rotation Test: A Re-Assessment of Its Use as a Tool to Monitor Motor Impairment and Functional Recovery in Rodent Models of Parkinson’s Disease Anders Björklunda,∗ and Stephen B. Dunnettb a Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Swe

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_journal_of_parkinsons_disease.pdf - 2025-12-20

U nc or re ct ed A ut ho r P ro of Journal of Parkinson’s Disease xx (20xx) x–xx DOI 10.3233/JPD-202200 IOS Press 1 Review1 Animal Models of Parkinson’s Disease: Are They Useful or Not? 2 3 Roger A. Barkera,∗ and Anders Björklundb,∗ 4 aDepartment of Clinical Neuroscience and WT-MRC Cambridge Stem Cell Institute, Forvie Site, Cambridge, UK 5 6 bDepartment of Experimental Medical Science, Wallenber

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_journal_of_parkinsons_disease_3.pdf - 2025-12-20

Journal of Parkinson’s Disease 10 (2020) 1503–1514 DOI 10.3233/JPD-202061 IOS Press 1503 Research Report BDNF Overexpression Increases Striatal D3 Receptor Level at Striatal Neurons and Exacerbates D1-Receptor Agonist-Induced Dyskinesia Simona Scheggia,1, Francesca Rossib,1, Sara Corsib, Silvia Fannib, Elisabetta Troncib, Ludovica Congiub, Romina Vargiub, Carla Gambaranaa, Ana Muñozc, Roberto Sta

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_journal_of_parkinsons_disease_5.pdf - 2025-12-20

JW-MDS#120476 96..109 Trophic Factor Gene Therapy for Parkinson’s Disease Jeffrey H. Kordower, PhD,1* and Anders Bjorklund, MD, PhD2 1Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA 2Wallenberg Neuroscience Center, Lund University, Sweden ABSTRACT: Parkinson’s disease (PD) is a chronic and progressive neurodegenerative movement disorder for which there i

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_mov_disord_0.pdf - 2025-12-20

nature neuroscience volume 18 | number 3 | mArCH 2015 319 co r r e s p o n d e n c e Gdnf, its binding receptor Gfrα1 or its main signaling receptor Ret die after birth mainly as a result of the lack of kidneys, but with intact catecholamine system, rendering postnatal analysis impossible4. However, conditional ablation using a loxP-Cre system (referred to as floxed) of GDNF main signaling recep-

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_nature_neuroscience.pdf - 2025-12-20

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_neuroscience_research.pdf - 2025-12-20

Hindawi Publishing Corporation Parkinson’s Disease Volume 2012, Article ID 370190, 5 pages doi:10.1155/2012/370190 Review Article Role of Serotonin Neurons in L-DOPA- and Graft-Induced Dyskinesia in a Rat Model of Parkinson’s Disease Eunju Shin,1 Elisabetta Tronci,2 and Manolo Carta2 1 Division of Neurobiology, Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden 2 Department of Bi

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_parkinsons_disease.pdf - 2025-12-20

pone.0039465 1..11 Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo Elodie Angot1*, Jennifer A. Steiner1,2, Carla M. Lema Tomé1, Peter Ekström3, Bengt Mattsson4, Anders Björklund4, Patrik Brundin1,2 1 Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden, 2 Center for Neurodegene

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_plos_one.pdf - 2025-12-20

pnas201221077 1..6 Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons Banafsheh Kadkhodaeia, Alexandra Alvarssonb,1, Nicoletta Schintub,1, Daniel Ramskölda, Nikolaos Volakakisa, Eliza Joodmardia, Takashi Yoshitakec, Jan Kehrc, Mickael Decressacd, Anders Björklundd,2, Rickard Sandberga,e, Per Svenningssonb, and Thomas Perlmanna

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_pnas_4.pdf - 2025-12-20

Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD Deirdre B. Hobana,b, Shelby Shrigleya,b, Bengt Mattssona, Ludivine S. Bregerc, Ulla Jarla, Tiago Cardosoa,b , Jenny Nelander Wahlestedta,b, Kelvin C

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_pnas_8.pdf - 2025-12-20

Chapter 5 - Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson’s disease A. Bjorklund and M. A. Cenci (Eds.) Progress in Brain Research, Vol. 184 ISSN: 0079-6123 Copyright ! 2010 Elsevier B.V. All rights reserved. CHAPTER 5 Viral vector-mediated overexpression of a-synuclein as a progressive model of Parkinson’s disease Ayse Ulusoy†, Mickael Decressac‡, Deniz K

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_progress_in_brain_research_2.pdf - 2025-12-20

Decressac 1..15 DOI: 10.1126/scitranslmed.3004676 , 163ra156 (2012);4 Sci Transl Med et al.Mickael Decressac in Nigral Dopamine Neurons Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling−-Synucleinα   Editor's Summary       -synuclein toxicity and highlight Nurr1 as a promising new target for neuroprotective therapy.αagainst -synuclein toxicity. These results suggest that Nurr1 is a key play

https://www.neurobiology.lu.se/sites/neurobiology.lu.se/files/publication_in_sci_transl_med.pdf - 2025-12-20