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Parametrisk design & miljöoptimering av industritrapptorn

Att byggsektorn står inför ett rådande klimatnödläge är ett faktum. Idag investeras hundratals miljarder kronor för att i framtiden kunna producera fossilfritt stål; trots det läggs lite fokus på miljöoptimering av konstruktioner. Syftet med arbetet är att utvärdera hur parametrisk design kan användas som verktyg för att miljöoptimera stålstommar i industritrapptorn samt undersöka vilken profiltypThe fact that the construction sector faces a prevailing climate emergency is undeniable. Today, hundreds of billions of kronor are being invested to develop fossil-free steel; yet little focus is placed on environmental optimization of constructions. The purpose of this work is to evaluate how parametric design can be used as a tool for environmental optimization of steel staircase towers, as wel

Disaster Risk Information Access in Karnali Province, Nepal: An egocentric social network analysis

Globally, climate change is exacerbating natural hazard frequencies and intensities. The Sendai Framework for Disaster Risk Reduction 2015-2030 places a high priority on the strengthening of understanding of disaster risk, primarily through strengthening access to disaster risk information. This priority is further affirmed in the Nepali National Disaster Risk Reduction Strategic Plan of Action 20

Active Learning Techniques for Annotation Efficiency in Detecting Coffee Berry Disease

Active Learning för annotationseffektivitet inom detektion av kaffebärssjukdom Två veckor och trettitusen bär senare så har jag nu äntligen lyckats rita rutor kring varje bär, allt för att min AI-modell ska bli så bra som möjligt. Blicken börjar sina och det repetitiva arbetet har gjort mig snurrig. Om det ändå hade funnits något bättre sätt tänker jag för mig själv, eller det kanske det gör? SnaArabica coffee production in Africa has declined significantly over the last half century, partly due to Coffee Berry Disease (CBD), caused by the fungus Colletotrichum kahawae. This disease results in substantial economic losses, estimated at USD 350- 500 million annually. Recent advancements in machine learning (ML) and computer vision offer powerful tools for disease detection. However, annotat

Climate Resilience through Shock-Sensitive Social Protection: The Role of Social Protection Systems during Climate Shocks in Malawi

Malawi is prone to compounding climate shocks, the main climate risks being extreme rainfall/floods and dry spells. To provide support to poor and vulnerable households, the country has an established social protection system, including a Social Cash Transfer Program (SCTP), which contains shock-sensitive social protection mechanisms to increase the coping capacity of beneficiaries to climate shoc

Evaluation and Validation of a New Risk Assessment Method

This Master’s thesis evaluates and validates a newly developed risk assessment tool designed for performance guarantees in the sales of rock crushing solutions at Sandvik Rock Processing Solutions, Stationary Crushing & Screening (Stat. C&S). The research aims to compare the new tool against the current expert-based method, assess the relevancy of the variables included, and propose necess

Expression and Purification of BoGal36A Wild-type and W297F Mutant

This study investigated the enzyme BoGal36A, produced by the gut bacterium Bacteroides ovatus. BoGal36A is an alpha-galactosidase, an enzyme that breaks down complex sugars. Unlike most alpha-galactosidases from the GH36 family, BoGal36A appears to cleave internal glycosidic bonds. In this study, the wild-type BoGal36A and mutant W297F was expressed in E. coli BL21 (DE3) cells and purified subsequ

Exploring the Potential of Enzymes to Combat Acne

Acne vulgaris is a widespread skin disease affecting approximately 9.4 % of the population. It arises from four primary factors: increased sebum production, hyperkeratinization, bacterial colonization, and inflammation, leading to both non-inflammatory and inflammatory lesions. Current treatments include topical and systemic anti-inflammatory agents, antibiotics, and retinols, which often have adv

Bead Structure in Freeze-Drying Processes: Analysis Techniques and Detailed Morphology Studies

Freeze drying, also known as lyophilization, is a crucial technology used in biotechnology and pharmaceutical preparation to preserve enzymes and other sensitive biological materials. This thesis investigates how different formulations and pellet dimensions impact the structural integrity of freeze-dried beads, essential for assessing their properties. Specifically, the study focuses on sucrose a

Framtidens Energilandskap: Energidelning och Energigemenskaper - En intervjustudie

Denna studie undersöker faktorer som påverkar bildandet av energigemenskaper och utbredningen av eldelning i Sverige. De regulatoriska omständigheterna, samhällsnyttorna och nyttorna utifrån en fastighetsägares perspektiv undersöks genom intervjuer med experter och aktörer inom fastighetssektorn. Resultaten visar att det sker en förändring i vad elanvändare efterfrågar från elsystemet, att flexibi

The impact of an ultrasound treatment on yellow peas on soaking time, phytic acid and protein digestibility

To increase the sustainability of the food sector and improve overall health, plant-based products have been advocated to be a solution. The plant-based products are often based on legumes. They contain a lot of nutrients and health benefits but also various antinutrients, including phytic acid which binds to several important minerals and proteins and reduces their bioavailability. Legumes are us

Investigating the Impact of Surfactants on Protein Folding: Insights from AF₄, DLS and ProbeDrum

Surfaktanter används inom många applikationer idag för att stabilisera eller förbättra proteiners funktion. Kartläggning av hur surfaktanter interagerar med proteiner påbörjades redan för flera årtionden sedan, men är ännu inte fullständig. Genom att förstå detta bättre kan surfaktanters användningsområden effektiviseras ytterligare och få produkter som läkemedel och rengöringsmedel som är effektiToday, proteins are used in a huge variety of industrial application ranging from detergents and pharmaceuticals to cosmetical products. Surfactants have the potential to increase solubility of poorly soluble protein, as well as hindering proteins in formulation to interact with the interface and thus protecting them from degradation. Even if the use of protein-surfactant system dates back decades

Left Ventricular Diastolic Function in Children with Atrial Septal Defects Improves After Closure by Means of Increased Hydraulic Force.

Hydraulic force aids diastolic filling of the left ventricle (LV) by facilitating basal movement of the atrioventricular plane. The short-axis atrioventricular area difference (AVAD) determines direction and magnitude of this force. Patients with atrial septal defect (ASD) have reduced LV filling due to the left-to-right shunt across the atrial septum and thus potentially altered hydraulic force.

Structure of LdtMt2, an l,d-transpeptidase from Mycobacterium tuberculosis

The transpeptidase LtdMt2 catalyzes the formation of the (3-3) cross-links characteristic of the peptidoglycan layer in the Mycobacterium tuberculosis cell wall. Bioinformatics analysis suggests that the extramembrane part of the enzyme consists of three domains: two smaller domains (denoted as A and B domains) and a transpeptidase domain (the C domain) at the C-terminus. The crystal structures of

N-Thio-β-lactams targeting L,D-transpeptidase-2, with activity against drug-resistant strains of Mycobacterium tuberculosis

Effective treatment of tuberculosis is frequently hindered by the emerging antimicrobial resistance of Mycobacterium tuberculosis. The present study evaluates monocyclic β-lactam compounds targeting the mycobacterial cell wall remodeling. Novel N-thio-β-lactams were designed, synthesized, and characterized on the L,D-transpeptidase-2, a validated target in M. tuberculosis. The candidates were eval

Participation in a digital self-management intervention for osteoarthritis and socioeconomic inequalities in patient-related outcomes

OBJECTIVE: To investigate changes in socioeconomic inequalities in patient-related outcomes and pain medication use, following participation in a digital self-management intervention for osteoarthritis (OA) in Sweden.METHOD: Participants with hip/knee OA enrolled in the digital intervention were included. Self-reported outcomes collected were the numerical rating scale (NRS) pain, activity impairm

Betrayal : Towards a Sociology of Threachery

Betrayal often hits the very foundations of socials bonds: the loyalty of the “We” that we have assumed and taken for granted is broken. This chapter will begin with a discussion of the meaning of betrayal where it is argued that betrayal is a breach of trust, when information is shared, or actions initiated beyond an agreed upon boundary of relations.The image of betrayal is associated with moral

Respect and anxiety : Guns as ambiguous symbols for criminally involved youth in Sweden

Youth gun violence has surged in Sweden recently. Quantitative studies have described the prevalence and geographical locations of gun violence, but little research has examined how perpetrators and victims themselves experience and make sense of guns. This article draws on ethnographic interviews with young men who have firsthand experience of gun violence in a criminal context. Drawing on narrat

The structure of the N-terminal module of the cell wall hydrolase RipA and its role in regulating catalytic activity

RipA plays a vital role during cell division of Mycobacterium tuberculosis by degrading the cell wall peptidoglycan at the septum, allowing daughter cell separation. The peptidoglycan degrading activity relies on the NlpC/P60 domain, and as it is potentially harmful when deregulated, spatial and temporal control is necessary in this process. The N-terminal domain of RipA has been proposed to play