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The tumor suppressor CYLD and the proto-oncogene BCL-3 are known to be deregulated in various cancer types. The molecular background of how these genes participate in carcinogenesis is not fully understood. CYLD is a deubiquitinating enzyme known to specifically target lysine 63 linked ubiquitin chains, which can negatively regulate the BCL-3, NF-κB and JNK signaling pathways, leading to a decreas
In 2011 the C9ORF72 repeat expansion was identified as the most frequent genetic mutation underlying FTD and ALS. The main aim of this study was to investigate clinical characteristics in a large C9ORF72-positive FTD family, and to compare these with the neuropathological findings.
In electromyographic (EMG) and functional magnetic resonance imaging (fMRI) studies, muscle and brain activity was compared during low levels of tooth clenching using a novel biting device to control bite force. A total of 21 healthy subjects performed motor tasks, comprising tooth clenching at 5, 10 and 20N. During all measurements, subjects kept the novel bite device between the anterior teeth d
The absorption, tissue distribution and excretion of enteral alpha-ketoglutarate (AKG) was studied in four experiments. Six male Sprague Dawley rats were used to investigate the excretion of AKG in urine and faeces. Thirty rats, randomly assigned to five groups, were used to investigate the distribution of AKG in body tissues. They were gavaged with AKG enriched with 3 muCi/kg BW of (14)C uniforml
Objective: The home birth rate in Sweden is less than 1 in 1000, and home birth is not included within the health care system. This study describes women's experiences concerning reactions to their decision to give birth at home. Design and setting: A nationwide survey (SHE - Swedish Homebirth Experience) in Sweden was conducted between 1992 and 2005 whereas 735 women had given birth to 1038 child
Purpose: The purpose of this paper is to sketch out the general tendencies, gaps, and opportunities within the body of research studying the social web as a new facet of public librarianship in order to delineate the findings so far and suggest directions for future research. Study design: Literature searches were conducted through the LISTA database, The ISI Web of Science database and The Direct
We show that the geometry of the Wilson lines, entering the operator definition of the transverse-momentum dependent parton distributions and that of the soft factor, follows from the kinematics of the underlying physical process in conjunction with the gauge invariance of the QCD Lagrangian. We demonstrate our method in terms of concrete examples and determine the paths of the associated Wilson l
Questions: How does the number of species in a community affect the level of genetic diversity of its constituent species? What is the relation between competitive interactions and the spatial distribution of genetic variation? When spatially structured, how is the genetic differentiation among subpopulations affected by competition and size of the community? Model features and key assumptions: A
This paper presents the results of an experimental study to investigate the behaviour of structurally damaged full-scale reinforced concrete beams retrofitted with CFRP laminates in shear or in flexure. The main variables considered were the internal reinforcement ratio, position of retrofitting and the length of CFRP. The experimental results, generally, indicate that beams retrofitted in shear a
Thermodynamic parameters are presented here illustrating the effects caused by the two anticancer active metal complexes cisplatin and oxaliplatin after introduction into four closely related RNA and DNA duplexes. The duplexes used are blunt end, fully complementary 15-mer duplexes with a centrally located either GG- or GNG (here: N = T or U) binding site. For all duplexes, a common trend of reduc
Objective Maternal diabetes during pregnancy is associated with congenital cardiac malformations and hypertrophic cardiomyopathy. Blood flow in the ductus venosus (DV) has been postulated to reflect cardiac function. The aim of our study was to investigate if diabetic pregnancies exhibit abnormal DV hemodynamics, hence indicating changes in fetal cardiac function. Methods The pulsatility index of
Background: Laboratory evolution is an important tool for developing robust yeast strains for bioethanol production since the biological basis behind combined tolerance requires complex alterations whose proper regulation is difficult to achieve by rational metabolic engineering. Previously, we reported on the evolved industrial Saccharomyces cerevisiae strain ISO12 that had acquired improved tole
High-spin states in Te-122 were populated in the reaction Se-82(Ca-48, alpha 4n) Te-122 at a beam energy of 200 MeV and gamma-ray coincidences weremeasured with the Gammasphere spectrometer. The previously known level scheme was extended to considerably higher spin. Maximally aligned states and several high-energy transitions feeding into some of these levels were observed. In addition, seven coll
The aim of this study was to identify factors associated with self-reported physical activity (PA), self-perceived physical fitness and competence in physical education (PE) among young children. The study included physical tests, anthropometric measures and a questionnaire. The study group comprised 206 children (114 boys and 92 girls, aged 8–12 years). Positive Odds Ratio was used in the logisti
Background: The survival of patients with locally advanced head and neck cancer is still poor, with 5-year survival rates of 24-35%. The identification of prognostic and predictive markers at the molecular and cellular level could make it possible to find new therapeutic targets and provide "taylor made" treatments. Established cell lines of human squamous cell carcinoma (HNSCC) are valuable model
A state-of-the-art 3D source imaging technique is used to extract the 3D two-pion source function in central and mid-central Au+Au collisions at GeV. The source function indicates a previously unresolved non-Gaussian tail in the directions of the pion pair transverse momentum (out) and along the beam (long). Model comparisons give robust estimates for several characteristics of the emission source
The current study evaluated amyloid-beta oligomers (A beta o) in cerebrospinal fluid as a clinical biomarker for Alzheimer's disease (AD). We developed a highly sensitive A beta o ELISA using the same N-terminal monoclonal antibody (82E1) for capture and detection. CSF samples from patients with AD, mild cognitive impairment (MCI), and healthy controls were examined. The assay was specific for oli
An essential part of a performance-based service life design format for wood exposed in outdoor applications is the effect of proper detailing in terms of avoiding moisture traps. Models for predicting degradation and non-performance caused by decay are functions of arbitrary climate history of combined moisture content and temperature. Therefore it is crucial to be able to predict the behaviour o
