Background: An increasing number of patients with central nervous system (CNS) tumor could survive to reproductive age and successfully have children, especially patients diagnosed at a younger age. However, it is largely unknown whether the history of CNS tumor and its treatments might affect their children. We aimed to explore the health status and school performance in offspring of survivors wi

BACKGROUND: Cytomegalovirus (CMV) specific T-cells are known to provide long-term control of CMV reactivation, which is a frequent complication of hematopoietic stem cell transplantation. We have studied 58 pediatric patients after hematopoietic stem cell transplantation who suffered from CMV reactivation to reveal which functional T cell subset is best correlating with successful reactivation res

Depletion of cellular immunity as a consequence of conditioning before allogeneic hematopoietic SCT (HSCT) frequently results in CMV reactivation, which may in turn lead to life-threatening infections and require timely antiviral treatment. We have investigated the functional signatures of CMV-specific CD4 and CD8+ T-cells in 191 samples from 118 individuals. We compared healthy donors with both p

Rapporten Humanistisk kunskap och kompetens presenterar och analyserar resultaten från en omfattande alumnundersökning riktad till Lunds universitets humaniora- och teologistudenter genomförd 2019. Undersökningen hade ett särskilt fokus på arbetsmarknad och arbetslivskoppling, men ställde även bredare frågor om humanistiska kompetenser och identitet.I rapportens första del redovisas vad alumnerna

A well-functioning arterial system for the transport of oxygen to the cells is essential for human health. The aorta has a key role for the provision of this physiological effect. Disturbances to aortic function can lead to majorsymptoms and even death due to ruptured abdominal aortic aneurysm (AAA). Multiple diseases may exacerbate, or alleviate the symptoms of aortic conditions.This thesis exami

Malaria is a potentially life-threatening disease with approximately half of the world’s population at risk. Young children and pregnant women are hit hardest by the disease. B cells and antibodies are part of an adaptive immune response protecting individuals continuously exposed to the parasite. An infection with Plasmodium falciparum can cause dysregulation of B cell homeostasis, while antibodi

Background: Patients with colorectal cancer were examined to determine (1) whether elevated carcinoembryonic antigen (CEA) levels, either before treatment or after surgery, was associated with an increased risk of overall or colorectal cancer-specific mortality or recurrence, and (2) whether high intensity follow-up would benefit those patients. Materials and methods: Post-hoc analysis based on 25

In 2016, the European Hematology Association (EHA) published the EHA Roadmap for European Hematology Research1 aiming to highlight achievements in the diagnostics and treatment of blood disorders, and to better inform European policy makers and other stakeholders about the urgent clinical and scientific needs and priorities in the field of hematology. Each section was coordinated by 1 to 2 section

Cells are exposed to a variety of mechanical cues, including forces from their local environment and physical properties of the tissue. These mechanical cues regulate a vast number of cellular processes, relying on a repertoire of mechanosensors that transduce forces into biochemical pathways through mechanotransduction. Forces can act on different parts of the cell, carry information regarding ma

Societal safety concerns maintaining critical social functions to protect the life and health of citizens as well as to meet their basic needs in times of crisis. Societal safety interventions are implemented by a range of actors in society. However, systematic evaluations of the suitability and effectiveness of proactive societal safety interventions are rather scarce – especially for complex int

Protein methylation occurs primarily on lysine and arginine, but also on some other residues, such as histidine. METTL18 is the last uncharacterized member of a group of human methyltransferases (MTases) that mainly exert lysine methylation, and here we set out to elucidate its function. We found METTL18 to be a nuclear protein that contains a functional nuclear localization signal and accumulates

Pure titanium has an HCP structure and lacks mechanical properties for many industrial purposes. The BCC phase of Ti is required to make alloys with increased strength compared to pure Ti. Iron is the most potent element for stabilising the BCC phase. However, the addition of Fe to Ti causes segregation issues during solidification, which can be avoided by diffusion-driven solid-state alloying. To

Bacterial pathogens evolve during chronic colonization of the human host by selection for pathoadaptive mutations. One of the emerging and understudied bacterial species causing chronic airway infections in patients with cystic fibrosis (CF) is Achromobacter xylosoxidans. It can establish chronic infections in patients with CF, but the genetic and phenotypic changes associated with adaptation duri

Objective: We evaluated whether patient-reported outcome trajectories (i.e., changes over time) differed by intraoperative compartmental cartilage lesion pattern over 4–6 years following arthroscopic meniscal surgery. Methods: In this ancillary study of the Knee Arthroscopy Cohort Southern Denmark cohort, we intraoperatively categorized cartilage lesions as isolated patellofemoral, isolated tibiof

We study analytically the dynamics of two-dimensional rectangular lattices with periodic boundary conditions. We consider anisotropic initial data supported on one low-frequency Fourier mode. We show that, in the continuous approximation, the resonant normal form of the system is given by integrable PDEs. We exploit the normal form in order to prove the existence of metastability phenomena for the

In this contribution we present some preliminary results on the dynamical evolution of two planet systems around stellar hosts evolving from the main sequence to the white dwarf phase. The aim is to study the instabilities triggered by stellar evolution that may bring planets onto the stellar surface or produce planetary scale collisions (hence debris) that could explain the metallic atmospheric p