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Live well, die well - an international cohort study on experiences, concerns and preferences of patients in the last phase of life: the research protocol of the iLIVE study

Introduction Adequately addressing the needs of patients at the end of life and their relatives is pivotal in preventing unnecessary suffering and optimising their quality of life. The purpose of the iLIVE study is to contribute to high-quality personalised care at the end of life in different countries and cultures, by investigating the experiences, concerns, preferences and use of care of termin

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer

To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loci that have not been previously reported. We replicated 26 signals and identified 10 new lead associations from previously reported loci. Rare-variant associations tended to be specific to po

Acute postoperative endophthalmitis : Microbiology from the laboratory to the bedside

Postoperative endophthalmitis is a dreaded complication of intraocular surgery. Acute presentations need prompt management and good knowledge of differential diagnoses. In the last 10 years, progress in direct microbial detection and identification from intraocular samples included the use of blood culture systems and, more recently, matrix-assisted laser desorption ionization time-of-flight mass

Factors associated with clinical progression to severe COVID-19 in people with cystic fibrosis: A global observational study

Background: This international study aimed to characterise the impact of acute SARS-CoV-2 infection in people with cystic fibrosis and investigate factors associated with severe outcomes. Methods Data from 22 countries prior to 13th December 2020 and the introduction of vaccines were included. It was de-identified and included patient demographics, clinical characteristics, treatments, outcomes an

Gender Equal Citizenship and Ethno-National Conflict : Women's Political Activism and Public Participation During the Northern Irish Troubles

This paper provides a theoretical synthesis of three research areas – gender, nationalism and citizenship – by linking together the gendered discourses of ethno-nationalism and citizenship. It explores the potential for building a gender equal citizenship in societies divided by ethno-national conflict. More specifically, it analyzes women’s activism and participation in public and political life

Therapeutic Value of Sentinel Lymph Node Biopsy in Patients With Melanoma: A Randomized Clinical Trial

Importance: Sentinel lymph node (SLN) biopsy is a standard staging procedure for cutaneous melanoma. Regional disease control is a clinically important therapeutic goal of surgical intervention, including nodal surgery. Objective: To determine how frequently SLN biopsy without completion lymph node dissection (CLND) results in long-term regional nodal disease control in patients with SLN metastase

Rare genetic variants explain missing heritability in smoking

Common genetic variants explain less variation in complex phenotypes than inferred from family-based studies, and there is a debate on the source of this ‘missing heritability’. We investigated the contribution of rare genetic variants to tobacco use with whole-genome sequences from up to 26,257 unrelated individuals of European ancestries and 11,743 individuals of African ancestries. Across four

Nonlinear Optics Studies on the MAX IV Storage Rings

The MAX IV Laboratory in Lund, Sweden, houses two electron storage rings operating at the energies 1.5, and 3 GeV. Both of these produce high-brilliance synchrotron radiation for beamline users. While the 1.5 GeV storage ring is a conventional third generation storage ring, employing a double-bend achromat structure, the MAX IV 3 GeV ring is the first realised fourth generation synchrotron. This r

Toward Effective Collaborations between Regional Climate Modeling and Impacts-Relevant Modeling Studies in Polar Regions

The aim of this workshop was to discuss the needs and challenges in using high-resolution climate model outputs for impacts-relevant modeling. Development of impacts-relevant climate projections in the polar regions requires effective collaboration between regional climate modelers and impacts-relevant modelers in the design stage of high-resolution climate projections for the polar regions.

Design and implementation of the European-Mediterranean Postgraduate Programme on Organ Donation and Transplantation (EMPODaT) for Middle East/North Africa countries

This prospective study reports the design and results obtained after the EMPODaT project implementation. This project was funded by the Tempus programme of the European Commission with the objective to implement a common postgraduate programme on organ donation and transplantation (ODT) in six selected universities from Middle East/North Africa (MENA) countries (Egypt, Lebanon and Morocco). The co