Filetype
INTRODUCTION: The pace of innovation has accelerated in virtually every area of tau research in just the past few years. METHODS: In February 2022, leading international tau experts convened to share selected highlights of this work during Tau 2022, the second international tau conference co-organized and co-sponsored by the Alzheimer's Association, CurePSP, and the Rainwater Charitable Foundation
We introduce a new method to calculate dark matter halo density profiles from simulations. Each particle is ‘smeared’ over its orbit to obtain a dynamical profile that is averaged over a dynamical time, in contrast to the traditional approach of binning particles based on their instantaneous positions. The dynamical and binned profiles are in good agreement, with the dynamical approach showing a s
Importance: Hypochondriasis, also known as health anxiety disorder, is a prevalent, yet underdiagnosed psychiatric disorder characterized by persistent preoccupation about having serious and progressive physical disorders. The risk of mortality among individuals with hypochondriasis is unknown. Objective: To investigate all-cause and cause-specific mortality among a large cohort of individuals wit
The main protease Mpro, nsp5, of SARS-CoV-2 (SCoV2) is one of its most attractive drug targets. Here, we report primary screening data using nuclear magnetic resonance spectroscopy (NMR) of four different libraries and detailed follow-up synthesis on the promising uracil-containing fragment Z604 derived from these libraries. Z604 shows time-dependent binding. Its inhibitory effect is sensitive to
We derive the order p 8 Lagrangian of odd intrinsic parity for mesonic chiral perturbation theory, and provide the resulting operator basis in the supplementary material. Neglecting the non-zero singlet trace, we find 999 operators for a general number of quark flavours Nf , 705 for Nf = 3 and 92 for Nf = 2. Our numbers agree with those obtained through the Hilbert series approach in the literatur
The Sun’s energy is effectively limitless. While resources such as coal or gas are finite, if you are able to capture and use solar power it doesn’t prevent anyone else from also using as much sunshine as they need.Except that isn’t quite the full story. Beyond a certain size, solar farms become large enough to affect the weather around them and ultimately the climate as a whole. In our new resear
Background: Thymic stromal lymphopoietin (TSLP) is released from the airway epithelium in response to various environmental triggers, inducing a type-2 inflammatory response, and is associated with airway inflammation, airway hyperresponsiveness (AHR), and exacerbations. TSLP may also induce AHR via a direct effect on airway smooth muscle and mast cells, independently of type-2 inflammation, altho
If you really want to know how much Australia contributes to the amount of carbon dioxide (CO₂) in the atmosphere, you have to study all the “sources” and “sinks”.Sources release CO₂ into the atmosphere, while sinks take it out. There are sources from human activities, such as burning fossil fuels, and there are natural sinks such as plants absorbing CO₂. You can tally it all up on a balance sheet
Following up on Steve Gudeman’s insight that economic categories are fundamentally cultural, this lecture juxtaposes different perspectives on money that transcend the conventional society/nature divide. It considers money as a unique semiotic phenomenon that imperils life itself by accelerating the production of entropy. The “agency” of the money artifact extends beyond society into the physical
Introduction: Approximately 25% of colon cancer (CC) patients having curative surgery will relapse. Therefore, it is crucial to identify patients with increased recurrence risk to offer them adjuvant chemotherapy. Three markers with prominent expression in fibroblasts: forkhead box Q1 (FOXQ1), matrix metalloproteinase-11 (MMP11), and thrombospondin-2 (THBS2), and the fibroblast expressed chemokine
