Infection tolerance is the ability of a host to limit the health effects of a given parasite load. A few recent studies have demonstrated genetic variation for tolerance, but little is known about how environmental factors affect tolerance. Here, we used the intestinal nematode Heligmosomoides polygyrus in laboratory mice to test for effects of protein malnutrition on tolerance. We performed an ex

Von Willebrand disease (VWD) is the most common genetic bleeding disorder. VWD is caused by a deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury and binds and stabilises coagulation factor VIII (FVIII) in the blood. Prophylaxis of surgical bleeding in patients with VWD requires consideration of the

Understanding the mechanisms that govern the combustion processes is important for being able to further increase the efficiency ofcombustion devices. Temperature is considered to be one of the most important parameters controlling the progression and finalproducts of combustion. Regulating the temperature in combustion devices enables higher degrees of efficiency to be achieved. Theengine compone

Haemolytic uraemic syndrome (HUS) is defined by the simultaneous occurrence of nonimmune haemolytic anaemia, thrombocytopenia and acute renal failure. This leads to the pathological lesion termed thrombotic microangiopathy, which mainly affects the kidney, as well as other organs. HUS is associated with endothelial cell injury and platelet activation, although the underlying cause may differ. Most

Background: Housing environments that hinder performance of daily activities and impede participation in social life have negative health consequences particularly for the older segment of the population. From a public health perspective accessible housing that supports active and healthy ageing is therefore crucial. The objective of the present study was to make an inventory of environmental barr

Background: WNT5A (-/-) mammary tissue has been shown to exhibit increased ductal elongation, suggesting elevated mammary cell migration. Increased epithelial cell migration/invasion has often but not always been linked to the epithelial-mesenchymal transition (EMT). In the current study, we investigated the loss of WNT5A in HB2 human mammary epithelial cells and hypothesized that this loss increa

There is sufficient evidence that statins have a protective role against breast cancer proliferation and recurrence, but treatment predictive biomarkers are lacking. Breast cancer cell lines displaying diverse sensitivity to atorvastatin were subjected to global transcriptional profiling and genes significantly altered by statin treatment were identified. Atorvastatin treatment strongly inhibited

As a by-product of a meeting between my university’s vice-chancellor and the manager of the largest bank in the small southern town of Ystad in 2006, I, almost accidentally, soon after came to commence teaching and researching media production, production studies, media industries studies or film and media industry studies, as the subject finally came to be called at Lund. The teaching part involv

Background: Pulse wave velocity (PWV) is a biomarker for arterial stiffness, clinically assessed by applanation tonometry (AT). Increased use of phase-contrast cardiac magnetic resonance (CMR) imaging allows for PWV assessment with minor routine protocol additions. The aims were to investigate the acquired temporal resolution needed for accurate and precise measurements of CMR-PWV, and develop a t

Background. Patients use self-care to relieve symptoms of common colds, yet little is known about the prevalence and patterns across Europe. Methods/Design. In a cross-sectional study 27 primary care practices from 14 countries distributed 120 questionnaires to consecutive patients (≥18 years, any reason for consultation). A 27-item questionnaire asked for patients' self-care for their last common

Latent autoimmune diabetes of the adults (LADA) accounts for up to 12% of all patients with diabetes. Initially the disease resembles type 2 diabetes (T2D); however, the typical presence of β cell autoantibodies indicates an autoimmune basis of LADA. While dysfunctional regulatory T cells (Tregs) have been implicated in autoimmune diabetes, these cells have been scarcely studied in LADA. The aim o

We have synthesized and evaluated in tissue phantom measurements a new type of Nd-codoped upconverting nanoparticles. They provide improved signal strengths from deep regions in a tissue phantom as compared to conventional upconverting nanoparticles, a result also suggesting they will provide less issues with heating the tissue during measurements.

Whereas existing business models for sustainability research have mainly focused on business model activities and sustainability outcomes for separate firms, we observe that alliances between small and large firms can influence a large firm's learning and dissemination of sustainable technologies, thereby contributing to the sustainable transformation of mass markets. According to the theoretical

The experiment aims to assess the tryptophan content of main cultivars of naked oat in China, and analyze the correlation between contents of tryptophan and protein. Oat flour was hydrolysed with papain, the fluorescence intensity of hydrolysate was detected at excitation wavelength of 288 nm and emission wavelength of 352 nm, and finally the tryptophan content was quantitated according to standar

Blood transfusion is a clinically significant and crucial process, which saves millions of lives every year. However,shortage of donated blood and the risk of virus transmission through transfusible blood seriously affect theavailability of the blood. Hemoglobin (Hb), owing to its oxygen carrying capacity, has been studied as a startingmaterial for the development of artificial blood substitutes/H

Baker’s yeast, Saccharomyces cerevisiae, is a promising cell factory for the sustainable utilization of renewable resources for the formation of products with commercial value. Among these, poly-3-D-hydroxybutyrate (PHB) is an extensively studied biopolymer naturally accumulated in some bacteria and archaea species through the formation of carbon granules. Its bio-based origin, biodegradability an