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The UK housing stock will play an important role in achieving the 2050 national carbon reduction targets. Upgrading the energy performance of the existing housing stock is a significant challenge because retrofit activities are shaped by a wide range of fragmented policies, programmes and actors. Existing approaches to housing retrofit focus on regulations, financial incentives and information pro
Urban nature is typically managed through top-down, bureaucratic, and expert-driven approaches that tend to rationalize and simplify the interactions between humans and their surround- ings. In the last few decades, there has been a significant push in cultural geography and the design disciplines to develop a relational ontology of urban nature, a perspective that emphasizes the hybrid connection
Seattle has long been considered a city in harmony with nature, a metropolis inseparable from and infused with the dramatic and picturesque Pacific Northwest landscape. Today, the city is frequently cited as a leader in sustainable urban development and this is due in large part to its unique relationship with its natural surroundings. However, the historical record of Seattle reveals this harmoni
We consider in this paper the relations between built form and everyday practices of home-living. These we see as co-constituting a combined domestic carbon space in which sociomaterial interdependencies are constantly at work. Carbon emissions are necessarily caught up in these interdependencies and not separable from them. We use the case of the mainstreaming of zero carbon (zero-C) housing in t
The notion of the ‘urban laboratory’ is increasingly striking a chord with actors involved in urban change. Is this term simply a metaphor for urban development or does it suggest urbanization by substantially different means? To answer this question, we review the work of science and technology studies (STS) scholars who have empirically investigated laboratories and practices of experimentation
The increasing threat of climate change has created a pressing need for cities to lower their carbon footprints. Urban laboratories are emerging in numerous cities around the world as a strategy for local governments to partner with public and private property owners to reduce carbon emissions, while simultaneously stimulating economic growth. In this article, we use insights from laboratory studi
Drawing on a postcolonial perspective and theories of strategic narratives and silences, this article looks at how Sweden’s feminist foreign policy (FFP) was reported in the media of conflict-affected states. It improves our understanding of feminist foreign policy reception by showing that from twenty selected countries, only newspapers in ten states had content on the FFP. It is argued that this
SUMMARYHigh prenatal detection rates of complex congenital heart defects (CHD) Aim: To analyze prenatal detection rates of complex CHD after the implementation of an expanded three-tiered screening model at the Skane University Hospitals in Lund and Malmö in 2015. Methods: Retrospective review of pregnancies screened from January 1, 2015 and being born by June 30, 2018. Complex CHD was defined as
The Arctic is exposed to even faster temperature changes than most other areas on Earth. Constantly increasing temperature will lead to thawing permafrost and changes in the methane (CH4) emissions from wetlands. One of the places exposed to those changes is the Abisko-Stordalen Mire in northern Sweden, where climate and vegetation studies have been conducted since the 1970s. In our study, we anal
Archaea often live in extreme, harsh environments such as acidic hot springs and hypersaline waters. To date, only two icosahedrally symmetric, membrane-containing archaeal viruses, SH1 and Sulfolobus turreted icosahedral virus (STIV), have been described in detail. We report the sequence and three-dimensional structure of a third such virus isolated from a hyperthermoacidophilic crenarchaeon, Sul
Transposon mutagenesis is a tool that is widely used for the identification of genes involved in the virulence of bacteria. Until now, transposon mutagenesis in Clostridium perfringens has been restricted to the use of Tn916-based methods with laboratory reference strains. This system yields primarily multiple transposon insertions in a single genome, thus compromising its use for the identificati
Genomic parasites have evolved distinctive lifestyles to optimize replication in the context of the genomes they inhabit. Here, we introduced new DNA into eukaryotic cells using bacteriophage Mu DNA transposition complexes, termed 'transpososomes'. Following electroporation of transpososomes and selection for marker gene expression, efficient integration was verified in yeast, mouse and human geno
Icosahedral dsDNA viruses isolated from hot springs and proposed to belong to the Tectiviridae family infect the Gram-negative thermophilic Thermus thermophilus bacterium. Seven such viruses were obtained from the Promega Corporation collection. The structural protein patterns of three of these viruses, growing to a high titer, appeared very similar but not identical. The most stable virus, P23-77
PURPOSE OF REVIEW: The extracellular matrix (ECM) is critical for all aspects of vascular pathobiology. In vascular disease the balance of its structural components is shifted. In atherosclerotic plaques there is in fact a dynamic battle between stabilizing and proinflammatory responses. This review explores the most recent strides that have been made to detail the active role of the ECM - and its
Communication between the soma and germline optimizes germ cell fate programs. Notch receptors are key determinants of germ cell fate but how somatic signals direct Notch-dependent germ cell behavior is undefined. Here we demonstrate that SDN-1 (syndecan-1), a somatic transmembrane proteoglycan, controls expression of the GLP-1 (germline proliferation-1) Notch receptor in the Caenorhabditis elegan
Debattartikel om förslaget till direktiv rörande reglering av minimilöner i EU.
Introduction: Making Informed Decisions to Aid Timely Management of Parkinson's Disease (MANAGE-PD) is a clinician-reported tool designed to facilitate timely identification and management of patients with advancing Parkinson's disease (PD) with suboptimal symptom control while on standard therapy. The objective of this study was to evaluate the validity and clinical value of the tool. Methods: Dr
Infections due to the opportunistic fungus Candida have been on the rise in the last decades, especially in immunocompromised individuals and hospital settings. Unfortunately, the treatments available today are limited. Thrombin-derived C-terminal peptide (TCP-25) is an antimicrobial peptide (AMP) with antibacterial and immunomodulatory effects. In this work, we, for the first time, demonstrate th
We consider the problem of variable selection in high-dimensional settings with missing observations among the covariates. To address this relatively understudied problem, we propose a new synergistic procedure—adaptive Bayesian SLOPE with missing values—which effectively combines SLOPE (sorted l 1 regularization) with the spike-and-slab LASSO (SSL) and is accompanied by an efficient stochastic ap
