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Evaluation of in vitro testing strategies for hazard assessment of the skin sensitization potential of “real-life” mixtures : The case of henna-based hair-colouring products containing p-phenylenediamine

Background: Allergic contact dermatitis caused by henna-based hair-colouring products has been associated with adulteration of henna with p-phenylenediamine (PPD). Objectives: To develop a testing approach based on in vitro techniques that address key events within the skin sensitization adverse outcome pathway in order to evaluate the allergenic potential of hair-colouring products. Methods: The

Mott variable-range hopping transport in a MoS2 nanoflake

The transport characteristics of a disordered, multilayered MoS2 nanoflake in the insulator regime are studied by electrical and magnetotransport measurements. The MoS2 nanoflake is exfoliated from a bulk MoS2 crystal and the conductance G and magnetoresistance are measured in a four-probe setup over a wide range of temperatures. At high temperatures, we observe that lnG exhibits a -T-1 temperatur

Filtered Reaction Rate Modelling in Moderate and High Karlovitz Number Flames : an a Priori Analysis

Direct numerical simulations (DNS) of statistically planar flames at moderate and high Karlovitz number (Ka) have been used to perform an a priori evaluation of a presumed-PDF model approach for filtered reaction rate in the framework of large eddy simulation (LES) for different LES filter sizes. The model is statistical and uses a presumed shape, based here on a beta-distribution, for the sub-gri

Carbon use efficiency of mycorrhizal fungal mycelium increases during the growing season but decreases with forest age across a Pinus sylvestris chronosequence

In boreal forest soils, mycelium of mycorrhizal fungi is pivotal for regulating soil carbon (C) cycling and storage. The carbon use efficiency (CUE), a key parameter in C cycling models, can inform on the partitioning of C between microbial biomass, and potential soil storage, and respiration. Here, we test the dependency of mycorrhizal mycelial CUE on stand age and seasonality in managed boreal f

Sarcopenia is common in adults with complex congenital heart disease

Background: Adults with complex congenital heart disease (CHD) have reduced aerobic capacity and impaired muscle function. We therefore hypothesized that patients have a lower skeletal muscle mass and higher fat mass than controls. Methods: Body composition was examined with full body Dual-Energy x-ray Absorptiometry (DXA) in 73 patients with complex CHD (mean age 35.8 ± 14.3, women n = 22) and 73

Quality of life in persons with hearing loss : a study of patients referred to an audiological service

Objective: To investigate the relationship between hearing loss (HL) and general quality of life (QoL) in adults seeking hearing aids (HAs). Design: The patients completed the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire’s general part and a questionnaire measuring self-assessed communication ability (Abbreviated Profile of hearing Aid Benefit—AP

Adjustable mini-sling compared with conventional mid-urethral slings in women with urinary incontinence : a 3-year follow-up of a randomized controlled trial

Introduction and hypothesis: The aim of this study was to compare the long-term subjective outcomes of an adjustable single-incision sling (Ajust®) vs standard mid-urethral slings (SMUS) for the treatment of women with stress urinary incontinence. Methods: This study was designed as a multicenter prospective randomized trial. Women under 60 years old with objectively verified stress urinary incont

Advancing research toward faster diagnosis, better treatment, and end of stigma in epilepsy

Seven large European Union (EU)–funded epilepsy-related research projects joined forces in May 2018 in Brussels, Belgium, in a unique community building event—the epiXchange conference. During this conference, 170 investigators from the projects DESIRE, EpimiRNA, EPISTOP, EpiTarget, EpiXchange, and EpiPGX as well as the European Reference Network EpiCARE, met up with key stakeholders including rep

CD21−/low B cells associate with joint damage in rheumatoid arthritis patients

Depletion of B cells is beneficial in rheumatoid arthritis (RA) patients with autoantibodies to citrullinated proteins (ACPA) and/or the Fc portion of immunoglobulins (rheumatoid factor [RF]), suggesting a role for B cells in disease pathogenesis. To date, however, the identity of specifically pathogenic B cell subsets has not been discovered. One candidate population is identified by the low expr

Pearls randomized lifestyle trial in pregnant hispanic women with overweight/obesity : Gestational weight gain and offspring birthweight

Background: Inappropriate gestational weight gain (GWG) has been associated with adverse perinatal events. High rates of GWG have been reported among Hispanic women. Observational studies indicate that dietary and physical activity interventions during the prenatal period may improve maternal and infant health, but very few randomized trials have been conducted among high-risk overweight/obese His

Contribution of obesity associated genetic variants to anthropometric somatotype components

The somatotype is a useful method in the analysis of body morphology but no study has identified genetic variants associated with its components. The aim of this study is o replicate the association of 21 SNPs with obesity and to explore their association with the somatotype components, in a sample from the Basque Country (Spain). A case-control study was performed in 472 adults from 18 to 79 year

Exploring Prospects for Agonistic Encounters in Conflict Zones : Investigating Dual Narrative Tourism in Israel/Palestine

This article contributes to the emerging literature on possibilities to disseminate agonistic narratives in seemingly deadlocked conflict settings. In this context, conflict parties’ existence is often perceived as being under threat, which makes it demanding to question the current societal order. However, even in the most protracted of conflicts, narratives exist that challenge concurring undersThis article contributes to the emerging literature on possibilities to disseminate agonistic narratives in seemingly deadlocked conflict settings. In this context, conflict parties’ existence is often perceived as being under threat, which makes it demanding to question the current societal order. However, even in the most protracted of conflicts, narratives exist that challenge concurring unders

Copeptin relates to a fatty liver and measures of obesity in a South African population with mixed ethnicities

Purpose: Elevated copeptin, a vasopressin marker, is linked to metabolic disease, and obese rats with low-vasopressin concentration had a decreased risk of liver steatosis. We here investigated the association between copeptin and nonalcoholic fatty liver disease (NAFLD) and possible differences in copeptin concentration between ethnicities. Methods: In this cross-sectional study of 361 South Afri

Incidents resulting in health care among older people with intellectual disability in comparison with the general population : A national register study

Background: Older people with intellectual disability (ID) are at high risk of incidents leading to hospital visits. Method: Through national registers, 7936 people with ID, aged 55+ years in 2012, and a same-aged referent cohort from the general population were identified. Information on diagnoses made in inpatient and outpatient specialist health care during 2002–2012 was collected. Results: Com

Securing human rights through risk-management methods : Breakthrough or misalignment?

This is a study of three authoritative instruments that promote a common idea: economic activities and development should be conducted with respect for human rights. The World Bank Framework, the International Financial Corporation Performance Standards and the UN Guiding Principles on business and human rights are examined to get clarity on how human rights risk management differs from more conve

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Artikeln presenterar resultat från ett forskningsprojekt som studerade postmoderna, multikulturella och självbiografiska drag hos den spanske författaren Juan Goytisolo. Det visade sig att de personliga övertygelserna genomsyrade alla delar av författarens verk, men dessutom visade det sig att detsamma gällde ett antal kritiker, översättare och forskare som valt att skriva om författaren.

Cerebrospinal fluid concentrations of extracellular matrix proteins in Alzheimer's disease

Background: Brevican, neurocan, tenascin-C, and tenascin-R are extracellular matrix (ECM) proteins that are mainly expressed in the brain. They play important roles in proliferation and migration of neurons and other cell types in the brain. These ECM proteins may also be involved in various pathologies, including reactive gliosis. Objective: The aim of the study was to investigate if ECM protein

Performance of Fully Automated Plasma Assays as Screening Tests for Alzheimer Disease-Related β-Amyloid Status

Importance: Accurate blood-based biomarkers for Alzheimer disease (AD) might improve the diagnostic accuracy in primary care, referrals to memory clinics, and screenings for AD trials. Objective: To examine the accuracy of plasma β-amyloid (Aβ) and tau measured using fully automated assays together with other blood-based biomarkers to detect cerebral Aβ. Design, Setting, and Participants: Two pros

RIFM fragrance ingredient safety assessment, 2-isobutyl-4-methyltetrahydro-2H-pyran-4-ol, CAS registry number 63500-71-0

2-Isobutyl-4-methyltetrahydro-2H-pyran-4-ol) was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that 2-isobutyl-4-methyltetrahydro-2H-pyran-4-ol is not genotoxic, does not have skin sensitization potential, and provided an MOE >100 for the repeated dose,