Finite Element Model to Reproduce the Effect of Pre-Stress and Needle Insertion Velocity During Infusions into Brain Phantom Gel
Convection-enhanced delivery (CED) is a technique to bypass the blood-brain barrier and deliver therapeutic agents into the brain. However, animal studies and preliminary clinical trials have reported reduced efficacy to transport drugs in specific regions, attributed mainly to backflow, in which an annular zone is formed outside the catheter and the fluid preferentially flows toward the surface o