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Thaw pond development and initial vegetation succession in experimental plots at a Siberian lowland tundra site
Permafrost degradation has the potential to change the Arctic tundra landscape. We observed rapid local thawing of ice-rich permafrost resulting in thaw pond formation, which was triggered by removal of the shrub cover in a field experiment. This study aimed to examine the rate of permafrost thaw and the initial vegetation succession after the permafrost collapse. Methods In the experiment, we mea
Between the world and me. Bokkrönika av Peter Svensson
Reply: Heterozygous PINK1 p.G411S in rapid eye movement sleep behaviour disorder
Roundtable on Money : An exchange on Money for the People
p53 maintains baseline expression of multiple tumor suppressor genes
TP53 is the most commonly mutated tumor suppressor gene and its mutation drives tumorigenesis. Using ChIP-seq for p53 in the absence of acute cell stress, we found that wild-type but not mutant p53 binds and activates numerous tumor suppressor genes, including PTEN, STK11(LKB1), miR-34a, KDM6A(UTX), FOXO1, PHLDA3, and TNFRSF10B through consensus binding sites in enhancers and promoters. Depletion
Care professional's experiences about using Liverpool Care Pathway in end-of-life care in residential care homes
Background: Residential care homes (RCHs) play an important role in end-of-life care, being the most common place of death for elderly people in several European countries. Care pathways such as the Liverpool Care Pathway for the Dying Patient (LCP) are used to improve and ensure quality care at the end of life. There is a lack of scientific evidence supporting the use of care pathways. Design: A
S100 protein - A marker of brain injury. The release in CABG patients without neurological complications
S100 protein, normally not found in serum, is increased after cerebral injury and is also released during ECC. Patients with neurological complications following cardiac surgery have residual concentrations due to a prolonged release from cellular injury. The aim of the present study was to characterize the S100 release that occurs after CABG in a "normal" population without clinical brain dysfunc
S100 protein, an early and prognostic serum marker for brain damage following cardiac surgery
S100 protein is a marker for brain damage easily analysed in blood. The serum level immediatly after termination of extracorporeal circulation (ECC) is increased and associated to age and the duration of perfusion. A prolonged residual concentration indicates cellular brain damage. The objective of this study was to ascertain if the prognosis of individual patients, with stroke following ECC, coul
Is accepting circular reasoning in shaken baby studies bad science or misconduct?
Variation in maturity-onset diabetes of the young genes influence response to interventions for diabetes prevention
Context: Variation in genes that cause maturity-onset diabetes of the young (MODY) has been associated with diabetes incidence and glycemic traits. Objectives: This study aimed to determine whether genetic variation in MODY genes leads to differential responses to insulin-sensitizing interventions. Design and Setting: This was a secondary analysis of a multicenter, randomized clinical trial, the D
Neonatal alloimmune thrombocytopaenia associated with maternal HLA antibodies
Neonatal alloimmune thrombocytopaenia (NAIT) generally results from platelet opsonisation by maternal antibodies against fetal platelet antigens inherited from the infant's father. Newborn monochorionic twins presented with petechial haemorrhages at 10 hours of life, along with severe thrombocytopaenia. Despite the initial treatment with platelet transfusions and intravenous immunoglobulin, they b
En domstolspedagogisk ansats
En domstolspedagogisk ansats Wittgensteins (1953) privatspråksargument utmanar förståelsen vad det innebär att korrekt följa regler. Paradoxen är att det inte verkar finnas någon möjlighet att logiskt hävda att en förklaring av en regel kan binda framtida tillämpningar. Argumentet utmanar regelförståelsen. Enligt Wittgenstein är regelföljande en praxis och inget som utgår från tolkningar. Kripke (
Nonandrogenic anabolic hormones predict risk of frailty : European male ageing study prospective data
Context: Low levels of nonandrogenic anabolic hormones have been linked with frailty, but evidence is conflicting and prospective data are largely lacking. Objective: To determine associations between nonandrogenic anabolic hormones and prospective changes in frailty status. Design/Setting: A 4.3-year prospective observational study of community-dwelling men participating in the European Male Agei
Female exposure to phthalates and time to pregnancy : A first pregnancy planner study
STUDY QUESTION Is female exposure to phthalate metabolites associated with reduced fecundity, as estimated by prolonged time to pregnancy (TTP)? SUMMARY ANSWER Female exposure to monoethyl phthalate (MEP) but not monobutyl phthalate (MBP), monobenzyl phthalate (MBzP) and monoethylhexyl phthalate (MEHP) was associated with a longer TTP. WHAT IS KNOWN ALREADY Male exposure to phthalates is potential
Acquisition, maintenance and adaptation of invasion inhibitory antibodies against Plasmodium falciparum invasion ligands involved in immune evasion
Erythrocyte-binding antigens (EBAs) and P. falciparum reticulocyte-binding homologue proteins (PfRhs) are two important protein families that can vary in expression and utilization by P. falciparum to evade inhibitory antibodies. We evaluated antibodies at repeated time-points among individuals living in an endemic region in Nigeria over almost one year against these vaccine candidates. Antibody l
Intracranial haemorrhage in children and adolescents with severe haemophilia A or B - the impact of prophylactic treatment
The discussion of prophylactic therapy in haemophilia is largely focused on joint outcomes. The impact of prophylactic therapy on intracranial haemorrhage (ICH) is less known. This study aimed to analyse ICH in children with haemophilia, with a focus on different prophylaxis regimens and sequelae of ICH. We conducted a multicentre retrospective and prospective study that included 33 haemophilia ce
No increased prevalence of malignancies among first-degree relatives of 800 patients with chronic myeloid leukemia : A population-based study in Sweden
HIF-dependent Signaling Pathways in Cancer
The cellular response to hypoxia, primarily orchestrated by hypoxia-inducible factors (HIFs; mainly HIF-1α and HIF-2α), is at the center of several signaling pathways conferring aggressive tumor behavior. HIFs may be crucially involved in tumor initiation, as seen in clear cell renal cell carcinoma, as well as maintenance of resistance cancer stem cell phenotypes, as observed in glioma. In the fir
CD44 interacts with HIF-2α to modulate the hypoxic phenotype of perinecrotic and perivascular glioma cells
Hypoxia-inducible factors enhance glioma stemness, and glioma stem cells have an amplified hypoxic response despite residing within a perivascular niche. Still, little is known about differential HIF regulation in stem versus bulk glioma cells. We show that the intracellular domain of stem cell marker CD44 (CD44ICD) is released at hypoxia, binds HIF-2α (but not HIF-1α), enhances HIF target gene ac