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Advanced personalized immunotherapies still have to overcome several biomedical and technical limitations before they become a routine cancer treatment in spite of recent achievements. In adoptive cell therapy (ACT), the capacity to obtain adequate numbers of therapeutic T cells in the patients following ex vivo treatment should be improved. Moreover, the time and costs to produce these T cells sh
BACKGROUND: Adverse cardiovascular effects are associated with both diesel exhaust and road traffic noise, but these exposures are hard to disentangle epidemiologically. We used an experimental setup to evaluate the impact of diesel exhaust particles and traffic noise, alone and combined, on intermediary outcomes related to the autonomic nervous system and increased cardiovascular risk.METHODS: In
Accurate prediction on the pressurized discharge performance is significant to the safety operation of cryogenic propellant system. In the present study, a two-dimensional numerical model is established to simulate the fuel outflow with high-temperature gas injection. Both the environmental heat invasion and interfacial phase change are detailedly considered. The volume of fluid method is used to
Liquid hydrogen is a promising energy carrier due to its excellent performance. However, liquid hydrogen sloshing usually causes serious issues on its safety production, storage, transportation, application and management. To study fluid sloshing in cryogenic storage tanks, a numerical calculation model is developed with considerations of the environmental heat leakage and phase change occurring a
The history of racial science, as it emerged in Sweden and in other European countries in the nineteenth and twentieth centuries, is a standard research topic today. But notions of race are not only produced in scholarly contexts; they are also generated in the mass media, popular culture, and politics. The history of racialisation cannot only be studied by focusing on academia, in other words. We
BACKGROUND: There is emerging evidence that exposure to prenatal methylmercury (MeHg) from maternal fish consumption during pregnancy can differ between individuals due to genetic variation. In previous studies, we have reported that maternal polymorphisms in ABC-transporter genes were associated with maternal hair MeHg concentrations, and with children's early neurodevelopmental tests. In this st
I de nordiska länderna finns ett antal förvaltningsorgan som på olika sätt är knutna till parlamenten. Hit hör exempelvis Folketingets Ombudsmand(Danmark), Statens revisionsverk (Finland), Ríkisendurskoðun(Riksrevisionen, Island), Stortingets kontrollutvalg for etterretnings-,overvåkings- og sikkerhetstjeneste, EOS-utvalget (Norge) och Valprövningsnämnden (Sverige). Sådana organ kan ses som en avvIn a Western European system based on a traditional separation of powers, public administration is as a rule organised under the Government (or Cabinet), as part of the Executive. In addition to this kind of state authorities, the Nordic countries feature a number of administrative bodies attached to the Parliaments. This category includes Parliamentary Ombudsmen, National Banks, and National Audi
The Swedish constitution features a uniquely limited role of the King or Queen Regnant as Head of State among the European monarchies. Other constitutionalmonarchies, including the Scandinavian neighbouring countries of Denmark andNorway, award the Head of State certain formal legal powers. Contrastingly, theSwedish Head of State has no such role. Under the 1974 Instrument of Government, the King
Aims: Transthyretin amyloid cardiomyopathy (ATTR-CM) is the cardiac manifestation of transthyretin amyloidosis (ATTR). The aim of this study was to estimate healthcare resource use for ATTR-CM patients compared with heart failure (HF) patients, in Denmark, Finland, Norway, and Sweden. Methods and results: Data from nationwide healthcare registers in the four countries were used. ATTR-CM patients w
Background: Diagnosis of contact allergy (CA) to Amerchol L-101 (AL-101), a marker for lanolin allergy, is problematic. Positive patch-test reactions are frequently doubtful or weakly positive and difficult to associate with clinical relevance. Objective: To gain further insight on the allergic or irritant nature of skin reactions induced by AL-101 patch test. Methods: We re-tested in a dose–respo
BiPd is a noncentrosymmetric superconductor with Dirac-like surface states on both (010) and (01¯0) faces. The Dirac cone on (010) surface is intense and appears at 0.66 eV binding energy. These states have drawn much attention due to contradictory reports on dimensionality and the momentum of these Dirac fermions. We have studied the properties of these Dirac fermions using varied photon energies
B cells interact with T follicular helper (Tfh) cells in germinal centers (GCs) to generate high-affinity antibodies. Much less is known about how cognate T–B-cell interactions influence Th cells that enter circulation and peripheral tissues. Therefore, we generated mice lacking MHC-II expressing B cells and, by thoracic duct cannulation, analyzed Th cells in the efferent lymph at defined interval
Photoinduced carrier dynamical processes dominate the optical excitation properties of photocatalysts and further determine the photocatalytic performance. In addition, as the electrons generally possess a faster transfer rate than holes, hole transfer and accumulation are critical, and they play the key efficiency-limiting step during the photocatalytic process. Therefore, a comprehensive underst
Objectives: To compare the 1-year, 2-year and 5-year incidences of acute coronary syndrome (ACS) in patients with rheumatoid arthritis (RA) starting any of the biologic disease-modifying antirheumatic drugs (bDMARDs) currently available in clinical practice and to anchor these results with a general population comparator. Methods: Observational cohort study, with patients from Denmark, Finland, No
In this study, we investigate the phenomenology of self-transcendent experiences, in which the usual sense of self is lost. Based on a taxonomy of nine aspects of self and three types of content of consciousness, we compare ten accounts of such experiences acquired through in-depth interviews. Sense of separateness and identification with body and narrative self were reported as lost in all of the
