Acetylcholine (ACh) release was studied in awake, freely moving animals using in vivo microdialysis in the hippocampus of young (3-month-old) and aged (24-month-old) female Sprague-Dawley rats. Two groups of aged rats were selected on basis of their spatial learning performance in the Morris water maze: non-impaired aged rats which performed as well as the young control animals, and impaired aged

Hymns to Unknown Heroines part III – Elna, 2015 Slide and sound installationHymns to Unknown Heroines, part III is the latest iteration of a multifaceted work. The starting point was an anonymous photographic archive from the 1920s that depicts a Scottish family over several years. Many of the photographs portray women engaged in recreational activities, portraying an undemanding lifestyle that ca

The thermal inactivation of lyophilized chymotrypsin was studied at controlled water activities. At 60 °C the enzyme showed good stability except at aw 0.97, whereas at 75 °C considerable inactivation occured at most water activities. Increasing the amount of buffer on the preparation decreased the stability significantly. The optimal temperature of enzymatic activity was increased 14 °C, when the

The composition and content of the gastric phospholipids were followed during development and healing of indometha-cin-induced chronic, antral ulcers in rats. The individual phospholipids were identified by thin-layer chromatography and quantitatively estimated by spectrophotometric analysis of phosphate. No changes were found in phospholipid composition and content after a 24-hour fast or during

Enzymes immobilized by deposition onto a solid support at low enzyme loadings were shown to be stabilized by additives, such as proteins and PEG. The additive protects the enzyme from deactivation during immobilization. The amount of additive required to obtain full stabilization was dependent on the type of support material used and corresponded approximately to a monolayer coverage of the additi

Enzymes were deposited on different porous support materials and these preparations were used to catalyze reactions in organic media. Reactions were carried out at specific water activities, achieved by equilibrating both the enzyme preparation and the substrate solution at the desired water activity before mixing them and thereby starting the reactions. The reaction rates obtained at the same wat

1. In the rat hepatic artery, the SK(Ca) inhibitors UCL 1684 (300 nM) completely blocked, and scyllatoxin (1 μM) and d-tubocurarine (100 μM) partially inhibited EDHF relaxations when each of them was combined with charybdotoxin (300 nM). 2. The IK(Ca) inhibitors clotrimazole (3 μM) and 2-chlorophenyl-bisphenyl-methanol (3 μM) strongly depressed EDHF relaxations when each of them was combined with

PurposeThis paper aims to consolidate the knowledge in last mile logistics research, analyze the development of the research area, and provide future research directions.Design/methodology/approachA systematic literature review identified 154 peer-reviewed journal publications from 2001 to 2019 in 83 scientific journals contributing to last mile logistics research.FindingsMain topics in last mile

INTRODUCTION: Chronic peripheral neuropathic pain (CPNP) is a condition due to peripheral nervous system diseases or injury, but its prevalence is unknown in Italian primary care.AIM: The aim of this study is to assess the prevalence of CPNP in a rural primary care area in Northern Italy.MATERIALS AND METHODS: A multicenter audit study was carried out in a rural area in Northern Italy with 113 par

We followed 23 patients from the primary total hip arthroplasty to revision for a bacteriologically proven deep infection with a low virulent organism. The median time to revision was 14 (4-65) months. During this period, the maximum ESR value was median 50 (22-110) mm and the maximum CRP value was 35 (9-95) mg/L. 25 of the 98 CRP values recorded were normal (< 9 mg/L) and 22/89 ESR values were be