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Denna avhandling riktar sig mot tre viktiga problem inom kognitiv sjukdom:1) Vi saknar idag kliniska verktyg för att med säkerhet kunna ge en korrekt demensdiagnos. Det enda sättet man med 100 % säkerhet kan avgöra vilken specifik kognitiv sjukdom en person lidit av är genom obduktion och efterföljande undersökning av hjärnan. Endast en liten andel av forskningen inom detta fält rör individer som The first aim of this thesis was to evaluate the prevalence of cardiovascular disease (CaVD), hypertension (HT), and type 2 diabetes mellitus (T2DM) in the neurodegenerative disorders Alzheimer’s disease (AD) and Lewy body disease (LBD). These conditions are considered modifiable risk factors for vascular dementia (VaD), and recent research has proposed its association with AD. The field is consid

Background: Abiraterone acetate (AA) is an androgen biosynthesis inhibitor shown to prolong life in patients with castration-resistant prostate cancer (CRPC) already treated with chemotherapy. AA treatment results in dramatic declines in prostate-specific antigen (PSA) in some patients and no declines in others, suggesting the presence of molecular determinants of sensitivity in tumors. Objective:

Cyclopropane, c-C3H6, the simplest cycloalkane, is seldom included in detailed kinetic mechanisms for hydrocarbons, though it may exhibit unusual kinetic features yet to be analysed due to a lack of studies of its combustion characteristics. In this work, laminar burning velocities of cyclopropane flames have been determined using the heat flux method at atmospheric pressure and an initial gas mix

Perceiving humans is an important and complex problem within computervision. Its significance is derived from its numerous applications, suchas human-robot interaction, virtual reality, markerless motion capture,and human tracking for autonomous driving. The difficulty lies in thevariability in human appearance, physique, and plausible body poses. Inreal-world scenes, this is further exacerbated b

This paper considers the problem of jointly designing the transmit waveforms and weights for a frequency diverse array (FDA) in a spectrally congested environment in which unintentional spectral interferences exist. Exploiting the properties of the interference signal induced by the processing of the multi-channel mixing and low-pass filtering FDA receiver, the interference covariance matrix struc

On the surface, Abel Ferrara’s cult classic The Addiction (1995) about a New York grad student-turned-vampire appears to be a metaphor for drug addiction. Yet this cinematic nightmare, in which various characters gradually sink into the perils of evil, hides deeper metaphors still. What lies beneath this story of urban vampirism? Why is it staged in an academic environment? International law const

The tools for spectrally analyzing heart rate variability (HRV) has in recent years grown considerably, with emphasis on the handling of time-varying conditions and confounding factors. Time–frequency analysis holds since long an important position in HRV analysis, however, this technique cannot alone handle a mean heart rate or a respiratory frequency which vary over time. Overlapping

The self-assembly of an arylazopyrazole-based photosurfactant (PS), based on cetyltrimethylammonium bromide (CTAB), and its mixed micelle formation with CTAB in aqueous solution was investigated by small angle neutron and X-ray scattering (SANS/SAXS) and UV-vis absorption spectroscopy. Upon UV light exposure, PS photoisomerizes from E-PS (trans) to Z-PS (cis), which transforms oblate ellipsoidal m

Background: Approximately 180 mothers are treated in Swedish Intensive Care Units (ICU) due to preeclampsia each year. Although several clinical risk factors are known, prediction of critical disease is challenging. Two scavenger proteins, hemopexin (Hpx) and alpha-1-microglobulin (A1M) have been suggested to be associated with the oxidative stress seen in preeclampsia. The ratio of two other biom

En vägledning i att lära sig grunderna i att arbeta med Trisotech Enterprise Suite för att utforma arbetsflöden i BPMN med beslutspunkter som modelleras i DMN. Syftet är att utforma modeller och lösningar för strukturerat och automatiserat beslutsfattande i verksamhetsprocesser.

In past years, Sweden has been facing a rapid growth of photovoltaic cells, and the total PV installation capacity increased from 300 kW to 1090 MW (2006–2020). The increased number of PV users was a result of active support from the Swedish government with an aim of achieving multiple sustainable goals regarding renewable energy. This project evaluates the profitability of shared PV systems in co

Neonicotinoid insecticides applied to flowering crops can have negative impacts on bees, with implications for crop pollination. To assess if exposure to the neonicotinoid clothianidin via a treated crop (rapeseed) affected bee behaviour, pollination performance (to strawberry), and bee reproduction, we provided each of 12 outdoor cages with rapeseed (autumn-sown plants complemented with a few spr

Background: The risk of adults with a congenital heart defect (ACHD) developing heart failure, stroke, arrhythmias, and the need for valve replacement is increased compared to healthy peers. Evidence for the use of novel oral anticoagulants (NOAC) in this patient group is still lacking and vitamin K antagonists (VKA) are the primary choice for patients with a mechanical valve. The present aim was

Background and aims: Concerns regarding adverse events associated with the use of acid suppressants have increased. However, the impact of proton pump inhibitors (PPIs) and histamine‐2 receptor antagonists (H2RAs) on the risk of atherosclerotic cardiovascular disease (ASCVD) remains unknown. This study aimed to estimate the risk of ASCVD in association with the use of PPIs and H2RAs. Methods: This

A common issue affecting DNA methylation analysis in tumor tissue is the presence of a substantial amount of non-tumor methylation signal derived from the surrounding microenvironment. Although approaches for quantifying and correcting for the infiltration component have been proposed previously, we believe these have not fully addressed the issue in a comprehensive and universally applicable way.

Ultrasound optical tomography (UOT) is a hybrid imaging modality based on interaction between ultrasound and light, with a potential to extend optical imaging capabilities in biological tissues to depths of several centimeters. Several methods have been developed to detect the UOT signal. To better understand their potential for deep tissue imaging, we present a theoretical contrast-to-noise compa

When people are conversing, a key non-verbal aspect of communication is the direction in which the participants are looking, as this may convey where each person’s attention is focused. In a programming context, for instance an integrated development environment (IDE), the interaction design frequentlydirects the programmer’s gaze towards specific locations on-screen. For example, syntax highlight

The Keccak sponge function family, designed by Bertoni et al. in 2007, was selected by the U.S. National Institute of Standards and Technology (NIST) in 2012 as the next generation of Secure Hash Algorithm (SHA-3). Due to its theoretical and practical importance, cryptanalysis of SHA-3 has attracted a lot of attention. Currently, the most powerful collision attack on SHA-3 is Jian Guo et al.’s lin

In this work, we study self-supervised representation learning for 3D skeleton-based action recognition. We extend Bootstrap Your Own Latent (BYOL) for representation learning on skeleton sequence data and propose a new data augmentation strategy including two asymmetric transformation pipelines. We also introduce a multi-viewpoint sampling method that leverages multiple viewing angles of the same