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Ion channels and ion fluxes control many aspects of tissue homeostasis. During oncogenic transformation, critical ion channel functions may be perturbed but conserved tumor specific ion fluxes remain to be defined. Here we used the tumoricidal protein-lipid complex HAMLET as a probe to identify ion fluxes involved in tumor cell death. We show that HAMLET activates a non-selective cation current, w
National framework conditions directly affect the productivity of firms, but also moderate returns on their technological efforts. Although this has long been recognised, there is a dearth of quantitative analyses that openly consider this hypothesis. Using a data set of 15 425 manufacturing firms in 32 developing countries, we investigate the impact of national institutions on firms' total factor
Popular Abstract in Swedish Förlossnings- och barnläkare har i många år sökt efter ett instrument för utvärdering av det nyfödda barnets hälsotillstånd. Virginia Apgar introducerade 1953 ett poängsystem som bygger på en subjektiv bedömning av barnets hudfärg, hjärtfrekvens,reflexer/retbarhet, muskeltonus och andning. Koncentrationen i blodet av olika gaser, syror och baser speglar också det nyföddAcid-base status in umbilical cord blood is an objective measure of the fetus’ exposure to and ability to handle hypoxia. The objective of this thesis was to clarify some of the methodological pitfalls in interpreting umbilical cord blood gases and lactate values at birth. Study I pinpoints the methodological confounding in calculating base deficit (BD) with algorithms used in different brands of
Aims. Until recently, most high-resolution spectroscopic studies of the Galactic thin and thick discs were mostly confined to objects in the solar vicinity. Here we aim at enlarging the volume in which individual chemical abundances are used to characterise the thin and thick discs, using the first internal data release of the Gaia-ESO survey (GES iDR1). Methods. We used the spectra of around 2000
One of the most important factors when low energy houses are built is to have good heat recovery on the ventilation system. However, standard ventilation units use a considerable amount of electricity. This article discusses the consequences on a system level of using hybrid ventilation with heat recovery. The simulation program TRNSYS was used in order to investigate a ventilation system with hea
I ett barnahus samverkar olika myndigheter för att samordna utredningar som startas då det finns misstanke om brott mot barn. Målet är att samverkan ska leda till ett barnanpassat utredningsförfarande och ett bättre underlag för rättsprocessen. I denna bok beskrivs de barn som misstänks ha varit utsatta för brott, vem som är misstänkt förövare och vilken typ av brott som barnen misstänks ha varit
Colorectal cancer (CRC) is the third most common cancer globally, with approximately 1.2 million new cases every year. The highest incidence rates are seen in developed countries, thereby imposing dietary and lifestyle factors in the etiology of CRC. Accumulating epidemiological evidence suggests that obesity is a risk factor for CRC in particular in men, as weak or no associations are seen in wom
Popular Abstract in Swedish Hjärtkärlsjukdom är den främsta dödsorsaken i västvärlden och den bakomliggande orsaken är oftast ateroskleros. Ateroskleros, eller åderförkalkning, medför att blodkärlens väggar blir tjocka och förlorar sin normala rörlighet på grund av inlagring av fett och bildningen av ett s.k. aterosklerotiskt plack. Vissa kan leva med åderförkalkning ett helt liv utan att märka avAtherosclerosis is a chronic inflammatory disease characterized by the formation of lipid rich plaques in the arterial wall. Rupture of a plaque results in clinical manifestations such myocardial infarction or stroke. Atherosclerosis is a complex disease where both autoimmune responses towards atherosclerosis-related antigens and smooth muscle repair responses play important roles. This thesis con
Context/Objective: The variant rs13266634 in SLC30A8, encoding a beta-cell-specific zinc transporter, is associated with type 2 diabetes. We aimed to identify other variants in SLC30A8 that increase diabetes risk and impair beta-cell function, and test whether zinc intake modifies this risk. Design/Outcome: We sequenced exons in SLC30A8 in 380 Diabetes Prevention Program (DPP) participants and ide
Sustainable public procurement indicates that procurement is about more than just saving money. Other important interests such as social and environmental considerations can be promoted through public procurement. Thus, the Member States may use their purchasing power to procure goods and services that foster innovation, respect the environment and combat climate change while improving employment,
BACKGROUND AND PURPOSE: We tested the hypothesis that higher proportions of patients with minor stroke being treated with thrombolysis contribute to increasing overall rates of thrombolysis. METHODS: We included 1743 ischemic stroke patients (age 18-80 years) treated with thrombolysis, recorded in the Swedish stroke register Riks-Stroke between 2007 and 2010. Minor stroke was defined as National I
Tacos, pizza eller hämtmat följt av popcorn och chips i tv-soffan framför Idol eller På spåret: när veckan går mot sitt slut är det fredagsmys som gäller. I denna artikel, som bygger på en dokumentation utförd av Folklivsarkivet, Lunds universitet, åren 2011-2012, analyseras fredagsmys ur olika perspektiv. Med utgångspunkt i ett material bestående av frågelistsvar, en nätetnografisk undersökning o
Recent work has confirmed that genetic compatibility among mates can be an important determinant of siring success in sperm competition experiments and in free-ranging populations. Most of this work points towards mate choice of less related mates. However, there may also be the potential for mate choice for intermediate or even genetically similar mates to prevent outbreeding depression or hybrid
Fermentation of biomass residues and second generation biomasses is potentially a way to enable a sustainable production of hydrogen. Simulation models which calculate mass and energy balances, developed with Aspen Plus (R), are used to integrate the process steps necessary to produce pure hydrogen from biomass in a 2-stage fermentation process. Process and heat integration are introduced to reduc
Context: Prostate cancer (PCa) is one of the most common human malignancies and arises through genetic and epigenetic alterations. Epigenetic modifications include DNA methylation, histone modifications, and microRNAs (miRNA) and produce heritable changes in gene expression without altering the DNA coding sequence. Objective: To review progress in the understanding of PCa epigenetics and to focus
