The aviation sector's contribution to global CO2 emissions requires the exploration of sustainable energy alternatives, with hydrogen emerging as a promising candidate. Despite their potential, hydrogen aircraft propulsion systems are not yet commercially viable, primarily due to technical challenges such as cavitation in hydrogen pumps. This study aims to analyse and optimise the design of hy

Background: A decline in episodic memory is one of the earliest cognitive characteristics of Alzheimer disease and memory tests are heavily featured in cognitive composite endpoints that are used to demonstrate treatment efficacy. Assessments of episodic memory can take many forms including free recall, associate learning, and paragraph or story recall. Plasma biomarkers of Alzheimer disease are n

Sorption of water has a profound effect on the material properties of wood. The uptake of water vapour in wood and other materials releases more heat than the condensation of vapour to liquid water. This excess energy provides insights to the interactions and energy state of the absorbed water molecules. Modification of wood by acetylation is a common way of altering the wood-water interactions; h

This paper presents a comprehensive analysis of the operation management of a multi-node community microgrid (MG), emphasizing power flow constraints and the integration of photovoltaic (PV) and battery systems. This study formulates MG operation management as a multi-objective optimal power flow problem, aiming to minimize costs (maximize profits) and emissions simultaneously. The multi-objective

This case-control study examines differences in empathetic response of patients experiencing behavioral variant frontotemporal dementia using functional magnetic resonance imaging.

Concomitant fields are the unwanted transverse components that arise when spatial encoding gradients are applied in MRI. We measured the changing gradient magnetic field at multiple locations inside the scanner and examined the internal distribution and linearity of the three vector components of the field. Our results illustrate some not-so-obvious spatial characteristics of the gradient field, w

Selenium and sulfur are two closely related basic elements utilized in nature for a vast array of biochemical reactions. While toxic at higher concentrations, selenium is an essential trace element incorporated into selenoproteins as selenocysteine (Sec), the selenium analogue of cysteine (Cys). Sec lyases (SCLs) and Cys desulfurases (CDs) catalyze the removal of selenium or sulfur from Sec or Cys

Inosine monophosphate dehydrogenase (IMPDH) and guanosine monophosphate reductase (GMPR) belong to the same structural family, share a common set of catalytic residues and bind the same ligands. The structural and mechanistic features that determine reaction outcome in the IMPDH and GMPR family have not been identified. Here we show that the GMPR reaction uses the same intermediate E-XMP* as IMPDH

Many intracellular pathogens hijack host cell actin or its regulators for cell-to-cell spreading. In marked contrast, apicomplexan parasites, obligate intracellular, single cell eukaryotes that are phylogenetically older than the last common ancestor of animals and plants, employ their own actin cytoskeleton for active motility through tissues and invasion of host cells. A hallmark of actin-based

DEAD-box RNA helicases play various, often critical, roles in all processes where RNAs are involved. Members of this family of proteins are linked to human disease, including cancer and viral infections. DEAD-box proteins contain two conserved domains that both contribute to RNA and ATP binding. Despite recent advances the molecular details of how these enzymes convert chemical energy into RNA rem

RNA helicases of the DExD/H-box superfamily are critically involved in all RNA-related processes. No crystal structures of human DExH-box domains had been determined previously, and their structures were difficult to predict owing to the low level of homology among DExH-motif-containing proteins from diverse species. Here we present the crystal structures of the conserved domain 1 of the DEIH-moti

A growing body of studies focuses on sexual harassment and violence in nightlife venues, primarily as it affects adolescent and adult women. In these settings, the boundary between flirtation and unwanted sexual attention easily blurs. This study examines how young women reject such attention. It draws on in-depth interviews with 53 Spanish undergraduates aged 18 to 25 from a Madrid public univers

BACKGROUND: Knee osteoarthritis (OA) is a major public health issue causing chronic pain, impaired physical function, and reduced quality of life. As there is no cure, self-management of symptoms via exercise is recommended by all current international clinical guidelines. This review updates one published in 2015.OBJECTIVES: We aimed to assess the effects of land-based exercise for people with kn

Soil microorganisms are pivotal in the global carbon cycle, but the viruses that affect them and their impact on ecosystems are less understood. In this study, we explored the diversity, dynamics, and ecology of soil viruses through 379 metagenomes collected annually from 2010 to 2017. These samples spanned the seasonally thawed active layer of a permafrost thaw gradient, which included palsa, bog

OBJECTIVES: To report the long-term safety and efficacy of BAY 81-8973 in the LEOPOLD Kids extension phase.METHODS: Patients received BAY 81-8973 (25-50 IU/kg) at least twice weekly. The primary endpoint was safety, assessed in all patients who entered the extension phase (n = 82). Efficacy endpoints were assessed in patients without high-titre inhibitors/immune tolerance induction (n = 67).RESULT

BACKGROUND: Anterior segment ischaemia (ASI) is a rare but feared complication associated with strabismus surgery, arising from damage of the anterior ciliary arteries that run along the extraocular rectus muscles. It has been reported that the risk of ASI following strabismus surgery increases when the vertical rectus muscles are involved. The aim of the present study was to monitor anterior segm

Recension av Nils Uddenberg, Drömmaren. En bok om Sven Hedin

Recension av Fredrik Eriksson, Lars Ericson Wolke & Gunnar Åselius, Från Savolaxbrigaden till Särskilda skyddsgruppen. Svenska specialoperationer och specialförband från medeltid till 1995

Recension av Henrik Berggren, Landet utanför 1–3: Sverige och kriget 1939–1940 (2018); Sverige och kriget 1940–1942 (2021); Sverige och kriget 1943–1945 (2023)