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The importance of Cyclophilins and Mps1 in cancer

Hepatic fibrosis is a pathological response to chronic liver injuries such as chronic alcohol consumption, non-alcoholic fatty liver disease (NAFLD) or chronic viral infections. No antifibrotic compound has been approved for liver fibrosis and if the cause of the chronic injury is not solved, fibrosis can progress to cirrhosis. Currently the only treatment for liver cirrhosis is liver transplantat

Big accents in stockholm swedish : nuclear accents, prenuclear accents, and initiality accents

Stockholm Swedish has a distinction between so-called big accents and small accents (in addition to a lexical contrast between tone accent 1 and tone accent 2). The function and distribution of the big versus small accent has never been fully understood. West Germanic languages lack a corresponding distinction. While it is known that big accents appear on information-structural focus, this fact ca

Himmel och helvete : de första prästvigda kvinnornas okända erfarenheter

”Öppna köksskåpet där borta!” Därinne dolde sig en påbörjad insamling av ett unikt källmaterial. Materialet består av de första prästvigda kvinnornas berättelser om hur deras väg till prästvigning och de första åren i Svenska kyrkans tjänst sett ut. Berättelserna ger en bild av en levd erfarenhet som hittills inte varit känd men som är avgörande för förståelsen av Svenska kyrkan under 1900-talet,

On the prognostic value of Heparin-binding protein in Sepsis

Sepsis causes major morbidity and mortality worldwide. There is wide consensus that biomarkers have an important role in sepsis research and patient care. Heparin-binding protein (HBP) is a neutrophil-derived, proinflammatory and vascular permeability-inducing protein and a promising novel sepsis biomarker. In this thesis, we investigate some aspects of the prognostic accuracy and added value of s

Negative properties of quantifiers in English and Swedish

In this paper we report the results from two small-scale studies on monotone decreasing (negative) quantifying expressions (QEs) and their negative polarity properties. Some approaches to QEs view polarity item licensing and clause polarity (affirmation/denial) as distinct phenomena. Here, we investigate if this distinction holds for monotone decreasing QEs. In two studies (one on English and one

Pykognition

Python wrapper for AWS Rekognition APIPykognition is a Python wrapper for the Amazon Web Service (AWS) Rekognition API, which provides industry-grade face and emotion detection. For facial detection, the algorithm provides a score for the predicted probability that the image includes a face (or multiple faces). Each face is categorized in a FaceDetail object, which carries a host of metadata such

Healthy Lifestyle and Mortality Among Adults Receiving Hemodialysis : The DIET-HD Study

Rationale & Objective: A healthy lifestyle promotes cardiovascular health and reduces cardiac-related mortality in the general population, but its benefits for people receiving maintenance hemodialysis are uncertain. Study Design: Prospective cohort study. Setting & Participants: 5,483 of 9,757 consecutive adults receiving maintenance hemodialysis (January 2014 to June 2017, median dialysi

Women's experiences of the second stage of labour

Background: The second stage of labour is generally considered as an intensive part of labour. Despite this, knowledge about women's experiences of the second stage of labour is scant. Aim: To explore experiences of the second stage of labour in women with spontaneous vaginal birth. Methods: This is a qualitative study where twenty-one women with a spontaneous birth at term, were interviewed four

The Reception of Pistis Sophia and Gnosticism : Uncovering the Link Between Esoteric Milieus and Contemporary Academia

This article surveys the reception of the Gnostic text Pistis Sophia in esoteric milieus in nineteenth- and early twentieth-century Europe. The first part of the article contains an overview of the text and scholarship on it. Then follows a study of the reception of Pistis Sophia in a broader array of esoteric circles. It becomes clear that the text was hailed as an example of ancient and great spThis article surveys the reception of the Gnostic text Pistis Sophia in esoteric milieus in nineteenth- and early twentieth-century Europe. The first part of the article contains an overview of the text and scholarship on it. Then follows a study of the reception of Pistis Sophia in a broader array of esoteric circles. It becomes clear that the text was hailed as an example of ancient and great sp

Surgical aspects on patients with diabetes mellitus and chronic limb-threatening ischemia

Background: During the 21st century, diabetes mellitus (DM) and peripheral artery disease (PAD) have become global problems. It is estimated that 19-34% of individuals with DM will develop a foot ulcer during their lifetime, and many will be amputated.Aim:-To study dietary and lifestyle factors associated with prevention of PAD among individuals with DM. -To evaluate outcomes after vascular and en

Prospective association between dietary pesticide exposure profiles and postmenopausal breast-cancer risk in the NutriNet-Santé cohort

BACKGROUND: Some pesticides, used in large quantities in current agricultural practices all over Europe, are suspected of adverse effects on human reproductive health (breast and prostate cancers), through mechanisms of endocrine disruption and possible carcinogenic properties, as observed in agricultural settings. However, evidence on dietary pesticide exposure and breast cancer (BC) is lacking f

Site, frequency, and duration of pain in young children with spina bifida

PURPOSE: To investigate the: (1) percent of children with spina bifida (SB) complaining of pain, (2) frequency, duration, and cause of pain by sex, level of lesion type of SB, and ambulation status, (3) body sites reported to hurt, by variables in objective 2, and (4) associations between physical and mental/emotional health between caregiver and child.METHODS: Cross-sectional study of 101 caregiv

Virtual Development of Process Parameters for Bulk Metallic Glass Formation in Laser-Based Powder Bed Fusion

The development of process parameters and scanning strategies for bulk metallic glass formation during additive manufacturing is time-consuming and costly. It typically involves trials with varying settings and destructive testing to evaluate the final phase structure of the experimental samples. In this study, we present an alternative method by modelling to predict the influence of the process p

Familial Segregation of Venous Thromboembolism in Sweden: A Nationwide Family Study of Heritability and Complex Segregation Analysis

BackgroundThis is the first nationwide segregation analysis that aimed to determine whether familial venous thromboembolism (VTE) is attributable to inheritance and/or shared environment, and the possible mode of inheritance.Methods and ResultsThe Swedish Multi‐Generation Register was linked to the Swedish patient register for the period 1964 to 2015. Three generational families of Swedish‐born in

The experiences of early career geriatricians throughout Europe during the COVID-19 pandemic

The COVID-19 pandemic has severely affected older adults and brought about unprecedented challenges to geriatricians. We aimed to evaluate the experiences of early career geriatricians (residents or consultants with up to 10 years of experience) throughout Europe using an online survey. We obtained 721 responses. Most of the respondents were females (77.8%) and residents in geriatric medicine (54.

Komfortgolvvärme i flerbostadshus : Stor potential för att minska/öka energianvändningen

Denna artikel sammanfattar resultaten från ett SBUF-projekt som fokuserat på att undersöka hur golvvärme hanteras i projektering och beräkning, samt hur den specifika energianvändningen kan påverkas av komfortgolvvärme med hänsyn tagen till val av olika tekniska lösningar samt styrning och användning av dessa. Resultaten visar att energianvändningen kan variera kraftigt och att det finns stor förb