OBJECTIVE: In Huntington's disease (HD), the disease-causing huntingtin (HTT) protein is ubiquitously expressed and causes both central and peripheral pathology. In clinical HD, a higher body mass index has been associated with slower disease progression, indicating that metabolic changes may be involved in disease pathogenesis. Underlying mechanisms of metabolic changes in HD are not fully known,

Supplemental Instruction/Peer Assisted Study Sessions (SI-PASS) is a peer learning program used worldwide to improve students’ learning and performance in challenging courses in higher education. A bonus effect of the program is the transferable skills that the student leaders may develop when facilitating the study sessions. These student leaders can potentially gain communication, group manageme

Continued professional development (CPD), tailored to teachers’ needs and expectations, is required for updated skills and knowledge. In this study, twenty-five teachers working with first and second grade students participated in an 11-week programme focusing on enhancing classroom communication. The participating teachers were randomly assigned to either a direct intervention track (intervention

Background: The use of chat-based digital visits (eVisits) to assess infectious symptoms in primary care is rapidly increasing. The "digi-physical" model of care uses eVisits as the first line of assessment while assuming a certain proportion of patients will inevitably need to be further assessed through urgent physical examination within 48 h. It is unclear to what extent this approach can mitig

Projektets metodik ska ses som en första leverans med ett unikt resultat där klimatprestanda för el- och fjärrvärmenäten ges som unika timdata för energisystemen 365 dagar om året, idag och i framtiden. Det finns idag ett antal frivilliga system på marknaden för energi- och klimatklassning av byggnader. Dessa system har det gemensamma att de har som ambition att driva utvecklingen framåt.I den utv

I Växjö har Skanska uppfört radhus som uppfyller företagets interna krav för att kallas mörkgröna. Mörkgrönt byggande enligt Skanska betyder högt ställda krav på miljöprestanda vad gäller energi, klimat, material och vatten, exempelvis behöver projektet klara netto-noll primärenergibalans över året. Solallén består av 21 enplansradhus i Vikaholm i utkanten av Växjö, och är Skanska Sveriges andra m

The PAM50 gene expression subtypes and the associated risk of recurrence (ROR) score are used to predict the risk of recurrence and the benefits of adjuvant therapy in early-stage breast cancer. The Prosigna assay includes the PAM50 subtypes along with their clinicopathological fea-tures, and is approved for treatment recommendations for adjuvant hormonal therapy and chemotherapy in hormone-recept

We investigate the next-to-leading-colour (NLC) contributions to the colour matrix in the fundamental and the colour-flow decompositions for tree-level processes with all gluons, one quark pair and two quark pairs. By analytical examination of the colour factors, we find the non-zero elements in the colour matrix at NLC. At this colour order, together with the symmetry of the phase-space, it is re

Understanding the critical soil moisture (SM) threshold (θcrit) of plant water stress and land surface energy partitioning is a basis to evaluate drought impacts and improve models for predicting future ecosystem condition and climate. Quantifying the θcrit across biomes and climates is challenging because observations of surface energy fluxes and SM remain sparse. Here, we used the latest databas

Understanding the formation of topological defects in ferroelectric materials can provide access to their unusual physics, invaluable for possible applications of domain engineering in nanoelectronics. The present study shows the spontaneous formation of center-type topological defects in lead zirconate titanate (PZT) films, characterized by a strong in-plane radial electromechanical response on r

Governmental policies and business models are considered key elements for a transition to a circular economy. In current literature, there is a lack of understanding on how these two elements interact and how this understanding is used to accelerate the realisation of a circular economy. We shed light on this issue by conducting a systematic review of the literature in combination with a literatur

Empirical evidences in the library and the historian’s search tools: Union catalogues, bibliographies, databases, and the omission of Melchior Hofmann’s works from the Swedish national bibliographyThe article considers the connection between historians’ interpretations of the past and the search tools (catalogues, bibliographies, and databases) they use to access empirical source material in libra