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Total-body irradiation (TBI) followed by transfer of bone marrow cells from donors is routinely performed in immunology research and can be used to manipulate differentiation and/or function of bone cells. However, exposure to high-dose radiation can result in irreversible osteopenia, and transfer of heterogeneous cell populations can complicate interpretation of results. The goal of this research

Spaceflight results in reduced bone accrual and muscle atrophy in growing rodents. Some studies suggest that the detrimental effects of spaceflight are due, in part, to impaired growth hormone (GH) signaling. An experiment flown aboard STS-41 (October 6–10, 1990) evaluated the efficacy of recombinant human growth hormone (rhGH) in ameliorating the detrimental effects of spaceflight on the musculos

This article describes and analyses social structure, poverty, wealth, and economic inequality in Stockholm from 1650 to 1750. We begin by establishing the social structure, using census data and other sources. To study wealth and poverty, the main sources are a complete record of the wealth tax of 1715, comprising 17,782 taxpayers, and a total of 1,125 probate inventories sampled from the years 1

BACKGROUND: Central venous catheter (CVC) misplacement occurs frequently after right subclavian vein catheterization. It can be avoided by using ultrasound to confirm correct guidewire tip position in the lower superior vena cava prior to CVC insertion. However, retraction of the guidewire during the CVC insertion may dislocate the guidewire tip from its desired and confirmed position, thereby res

Background and Purpose:VIM (vimentin) is a cytoskeletal intermediate filament protein, which has been linked to atherosclerosis and thrombosis; both are important causes of stroke. We examined the relationship between circulating VIM and incidence of stroke, and if carotid plaque could modify the association in a prospective population-based cohort.Methods:This prospective study was based on the M

Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to

Med hjälp av den amerikanske sociologen Norbert Wiley försöker jag beskriva inre tal på ett sociologiskt och socialpsykologiskt sätt. Inre tal består av ord eller indikerade ord, kondenserade och fragmentariska repliker, och det befolkar vårt inre med både förflutna och framtida röster från det samhälle som vi lever i. Det påminner oss om att vi inte är determinerade i våra handlingar utan snarare

This article assesses the study of gender equality policies in European Union external actions with a focus on the theoretical and empirical routes to understanding the field in times of crises. It argues that the emerging body of literature on gender in European Union external relations makes it possible to explain, understand, and judge the European Union in global politics by rethinking the nat

This article provides a theoretical perspective on the question of how EU-Israeli/Palestinian relations should be conceived 50 years after the occupation. The article sets out how a critical social theory of normative power could be seen as a way both of analyzing and changing these relations. According to Craig Calhoun, critical social theory should be seen as an ‘interpenetrating body of work wh

We suggest that a renewed focus on integration (broadly conceived) would enablethe field to contemplate the ways in which crisis dynamics interconnect with and amplify three founding and (and unresolved) dilemmas of the European project. These can be summarized as (a) the constant tension between the goal of delivering an EU-wide market order versus the desire to ensure social solidarity, (b) the

This article uses political psychology to understand emotions such as anger, hate, and passion in the Brexit debate in order to demonstrate the wider value of the political psychology of European integration. It uses five strands of political psychology to understand European integration, drawing on evidence from the Brexit debate. These strands are individual cognitive psychology, social psycholo

Foreign Policies of EU Member States provides a clear and current overview of the motivations and outcomes of EU Member States regarding their foreign policy-making within and beyond the EU. It provides an in-depth analysis of intra-EU policy-making and sheds light, in an innovative and understandable way, on the lesser-known aspects of the inter-EU and extra-EU foreign policies of the twenty-eigh

The World Meteorological Organization has developed a set of headline indicators for global climate monitoring. These seven indicators are a subset of the existing set of essential climate variables (ECVs) established by the Global Climate Observing System and are intended to provide the most essential parameters representing the state of the climate system. These indicators include global mean su

Background: Acute occlusion of renal bridging stent grafts after fenestrated/branched endovascular aortic repair (F/B-EVAR) is an acknowledged complication with high morbidity that often results in chronic dialysis dependence. The feasibility and effect of timely or late (≥6 hours of ischemia) renal artery revascularization has not been adequately reported. Methods: We performed a retrospective, m

Introduction: Several blood-based biomarkers are associated with neuronal injury, but their utility in interventional clinical trials is unclear. This study retrospectively evaluated the utility of plasma neurofilament light (NfL) and total tau (t-tau) in an 18-month trial in mild Alzheimer's disease (AD). Methods: Correlation and conditional independence analyses and Gaussian graphical models wer

β-Galactose derivatives have recently been reported to selectively inhibit galectin-3, and a library of O3-arylated galactosides with varying substitution patterns was designed to study such inhibitions further. The O3-arylated galactosides were synthesized using diaryliodonium salts under mild and transition metal free conditions, providing the target products in moderate to good yields. An O3-tr