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Effect of Type 1 Diabetes on School Performance in a Dynamic World : New Analysis Exploring Swedish Register Data

This paper investigates if the effect of type 1 diabetes mellitus (T1DM) on school performance has changed over time using national Swedish population register data. The issue is of interest because management and treatment of the disease have improved over the last decades and, furthermore, because of changes in the educational grading system. Despite these changes, data indicate a persistent neg

Foreign Direct Investment and Value Added in Indonesia

Foreign Direct Investment (FDI) has increased in importance over the last decades, globally as well as in Indonesia. We examine how such inflows of FDI affects value added in Indonesia. The effect is positive: foreign firms generate relatively high levels of value added and they also seem to have a positive impact on value added in local firms. Moreover, FDI contribute to a structural change of th

Assistive technology in resource-limited environments : a scoping review

Purpose: It is estimated that only 5–15% of people in low and middle income countries (LMICs) who need assistive technologies (AT) have access to them. This scoping review was conducted to provide a comprehensive picture of the current evidence base on AT within LMICs and other resource limited environments. Method: The scoping review involved locating evidence, extracting data, and summarizing ch

Relationship between selected DNA polymorphisms and coronary artery disease complications

Background Coronary heart disease (CHD) development is complex in origin, with contributions from well-defined lifestyle and not well-determined genetic risk factors. The aim of this study is to report the relationship between certain SNPs and the risk of cardiovascular (CV) complications in patients with CAD confirmed by coronary angiography. Methods In the present study, 1345 subjects with CHD w

Chained Approach vs Contingent Valuation for Estimating the Value of Risk Reduction

To decide how much resources to spend on reducing mortality risk, governmental agencies in several countries turn to the value of a statistical life (VSL). VSL has been shown to vary depending on the size of the risk reduction, which indicates that WTP does not increase near-proportional in relation to risk reduction as suggested by standard economic theory. Chained approach (CA) is a stated prefe

Identification of novel drug candidate against mycobacterium tuberculosis inha protein through computer aided drug discovery

Tuberculosis is a common and often deadly infectious disease caused by Mycobacteria. WHO estimates that around eight million people are suffering from tuberculosis every year. The Administration of antibiotics fails due to the multi-drug resistant capability of Mycobacterium. Traditional methods require time and huge investment. Therefore, it is essential to provide an alternative strategy to trea

3D solar maps for the evaluation of building integrated photovoltaics in future city districts : A norwegian case study

Three-dimensional (3D) solar maps based on Radiance simulations are presented for a future city district in southern Norway. The surface mapping method provides the commercial developer with a practical tool to evaluate the potential for building integrated photovoltaics (BIPV). The solar maps identify the optimum roof and facade areas available for solar energy utilization. The importance of BIPV

Experimental evidence that honeybees depress wild insect densities in a flowering crop

While addition of managed honeybees (Apis mellifera) improves pollination of many entomophilous crops, it is unknown if it simultaneously suppresses the densities of wild insects through competition. To investigate this, we added 624 honeybee hives to 23 fields of oilseed rape (Brassica napus L.) over 2 years and made sure that the areas around 21 other fields were free from honeybee hives. We dem

Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis

Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be used to characterize disease, guide therapy, and monitor response. A

Glycogen metabolism in the glucose-sensing and supply-driven β-cell

Glycogen metabolism in β-cells may affect downstream metabolic pathways controlling insulin release. We examined glycogen metabolism in human islets and in the rodent-derived INS-1 832/13 β-cells and found them to express the same isoforms of key enzymes required for glycogen metabolism. Our findings indicate that glycogenesis is insulin-independent but influenced by extracellular glucose concentr

Natural history, risk factors and clinical features of primary hypogonadism in ageing men : Longitudinal Data from the European Male Ageing Study

Objective: In ageing men, the incidence and clinical significance of testosterone (T) decline accompanied by elevated luteinizing hormone (LH) are unclear. We describe the natural history, risk factors and clinical features associated with the development of biochemical primary hypogonadism (PHG, T < 10·5 nmol/l and LH>9·4U/l) in ageing men. Design, Patients and Measurements: A prospective observa

Safety in numbers for cyclists-conclusions from a multidisciplinary study of seasonal change in interplay and conflicts

In many European countries, it is a political goal that future growth in local travel should be absorbed by sustainable transport modes. Concerns that increased walking and cycling produce more accidents have been countered by the "safety in numbers" (SiN) argument. According to SiN, the more walkers/cyclists there are in a population, the lower their risk. SiN has been demonstrated in cross secti

Krigets sociologi: : Analyser av krigsvåld, koncentrationsläger, offerskap och försoning

I tidigare forskning om krig presenteras ofta ensidiga bilder av fenomenen krigsvåld, offerskap och försoning. Denna bok utgår från berättelser av överlevande efter kriget i Bosnien under 1990-talet. Syftet är att analysera hur de intervjuade beskriver dessa fenomen samt vilka diskursiva mönster som framträder i konstruktionen av begreppen ”offer” och ”förövare”. Mina frågeställningar är: Hur beskThis book analyzes verbally depicted experiences of survivors from the war in Bosnia and Herzegovina. One purpose to describe how the actors portray the social phenomenon of “war violence” “victimhood” and “reconciliation”, and the second aim is to analyze discursive patterns that emerges in the creation of the terms “victim” and “perpetrator”. My research questions are: (1) How do the interviewee

Evaluating the role of leukotriene-modifying drugs in asthma management : Are their benefits ‘losing in translation’?

Leukotrienes (LTs) initiate a cascade of reactions that cause bronchoconstriction and inflammation in asthma. LT-modifying drugs have been proved very effective to reduce inflammation and associated exacerbation however despite some illustrious clinical trials the usage of these drugs remains overlooked because the evidence to support their utility in asthma management has been mixed and varied be