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Background: Previous studies have proposed growth differentiation factor-15 (GDF-15) as a predictor of adverse cardiovascular outcomes and mortality. The present study aimed to determine if such associations remain after accounting for death as a competing risk, and if GDF-15 provides superior prediction performance than other biomarkers. Methods: Plasma GDF-15 levels and cardiovascular risk facto

Background: We have previously shown an association with substantially improved survival in breast cancer and melanoma for desloratadine and loratadine users, and set out to find whether an improved survival can be seen in tumors with and without a known response to immune checkpoint therapy, such as anti-CTLA-4 or anti-PD-1. Methods: We investigated survival and use of six common H1-antihistamine

The study evaluates the biogeochemical model ForSAFE-2D, designed to simulate water and chemical transport from the forest to the stream, by simulating the hydrology and the transport of the chemical tracer chloride (Cl−) along a forest hillslope in Northern Sweden. The simulated Cl− exports were in balance with the simulated inputs but measurements suggested a net release of Cl− from the catchmen

The field of studying EU external relations/actions has embraced and endorsed mainstream International Relations and European Integration theoretical orthodoxy over the past three decades. This ideological orthodoxy is proving catastrophic as the accumulation of economic, social, environmental, conflictual, and political crises are increasingly demonstrating. As Joseph Stiglitz succinctly puts it,

With well-structured chapters by leading scholars who explain key developments and concepts clearly, Islam and Popular Culture is the first comprehensive overview of this important subject

Background: Results on growth and nutrient intake in infants in the second half of infancy fed human milk or formulas with varying protein concentrations in combination with supplementary foods have not previously been reported. Methods: Seventy-one healthy infants were studied from 3 to 12 months of age. They were exclusively breast-fed until 3 months and were then randomly assigned to one of th

This chapter investigates how the challenging questions and tensions caused by migrants and their universalist claims for inclusion, have been approached and resolved in liberal democracies. By regarding the development of populism as a real and dangerous political phenomenon that has a significant traction, the chapter asks whether populism adds something new to this approach and resolution. More

Det uppskattas att år 2050 kommer tio miljoner människor att dö av infektionersom inte kan behandlas på grund av att bakterier blivit resistenta ochdärmed gjort antibiotika ineffektiv. Denna typ av dystopier är en form avresor både bakåt och framåt i tiden, och där samhället beskrivs som någotannat än vad vi är vana vid. Tanken om en framtid utan antibiotika – enså kallad postantibiotisk era – går

Using a simple model based on the knowledge of spherical and deformed Woods-Saxon potentials, it is shown that the recent observation of halo phenomena in 29F can be interpreted as evidence for the prolate deformation of the ground state of 29F. The prolate deformation is the result of the shell structure, which is unique in one-neutron resonant levels, in particular near degeneracy of the neutron

In situ studies using transmission electron microscopy (TEM) can provide insights to how properties, structures and compositions of nanostructures are affected and evolving when exerted to heat or chemical exposure. While high-resolved imaging can be obtained continuously, at video-framerates of hundreds of frames per second (fps), compositional analysis struggles with time resolution due to the l

This paper presents preparations, execution and reflection on results for the physics part of a CSI task for the European Union Science Olympiad 2010, taking place at the University of Gothenburg. The participants were required to make a graph of the cooling of a swede (Brassicanapus), as a proxy for the cooling of a murder victim, and to choose a mathematical expression for the cooling curve, as

The MoCu CO dehydrogenase enzyme not only transforms CO into CO2 but it can also oxidise H2. Even if its hydrogenase activity has been known for decades, a debate is ongoing on the most plausible mode for the binding of H2 to the enzyme active site and the hydrogen oxidation mechanism. In the present work, we provide a new perspective on the MoCu-CODH hydrogenase activity by improving the in silic

Abstract: Understanding intraspecific phenotypic variation in prey specialisation can help to predict how long-term changes in prey availability affect the viability of these phenotypes and their persistence. Generalists are favoured when the main food resources are unpredictable compared to specialists, which track the availability of the main prey and are more vulnerable to changes in the main f

Systematic assessments of cognition, fatigue, and mental health in survivors ofchildhood cancer can serve two different purposes. One is to enable research about development over time and medical predictors of cognitive deficits. The other is to identify individual patients in need of rehabilitation or interventions. The overall aim of this doctoral thesis was to contribute to the ongoing developm