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Cisplatin-induced duplex dissociation of complementary and destabilized short GG-containing duplex RNAs.

The ability of the anticancer active drug cisplatin to exert biological activity through interference with nucleic acid function is well documented. Since kinetics play a key role in determining product distributions in these systems, methods for accurate documentation of reactivity serve the purpose to identify preferential metal binding sites. In the present study, the aim has been to further ex

Formation of 10-100 nm Size-Controlled Emulsions through a Sub-PIT Cycle

We have re-examined the phase inversion temperature (PIT) emulsification process. This is a low-energy method that uses a physicochemical drive to produce very fine oil/water emulsions in the absence of high shear flows. We used the polyoxyethylene 8 cetyl ether (C16E8)/hexadecane/water system, which has a PIT of 76.2 degrees C. We find that successful emulsification depends oil two conditions. Fi

Scaffolding bracing of composite bridges during construction

Relatively little bracing of steel girders can significantly reduce possible risk of buckling failures, before the composite action between steel and concrete occurs. This paper intended both experimentally and numerically, to study the torsional bracing performance of a typical type of scaffoldings commonly used in bridge construction. Minor improvements in the structure of the scaffoldings as we

Digital nerve injuries: Epidemiology, results, costs, and impact on daily life.

Epidemiology, results of treatment, impact on activity of daily living (ADL), and costs for treatment of digital nerve injuries have not been considered consistently. Case notes of patients of 0-99 years of age living in Malmö municipality, Sweden, who presented with a digital nerve injury and were referred to the Department of Hand Surgery in 1995-2005 were analysed retrospectively. The incidence

Simple inversion formula for the small-angle X-ray scattering intensity from polydisperse systems of spheres

A practical inversion method to calculate the size distribution of colloidal homogeneous particles from small-angle scattering experiments is presented. It is based on the analysis of the deviations of the scattering signal from the Porod law. The resulting inversion formula provides a reliable way to assess complex size distributions such as power-law, multimodal or very broad distributions. It i

Semi-automatic segmentation of myocardium at risk in T2-weighted cardiovascular magnetic resonance

Background: T2-weighted cardiovascular magnetic resonance (CMR) has been shown to be a promising technique for determination of ischemic myocardium, referred to as myocardium at risk (MaR), after an acute coronary event. Quantification of MaR in T2-weighted CMR has been proposed to be performed by manual delineation or the threshold methods of two standard deviations from remote (2SD), full width

A model for the development of Aedes (Stegomyia) aegypti as a function of the available food

We discuss the preimaginal development of the mosquito Aedes aegypti from the point of view of the statistics of developmental times and the final body-size of the pupae and adults. We begin the discussion studying existing models in relation to published data for the mosquito. The data suggest a developmental process that is described by exponentially distributed random times. The existing data s

Topographic organization and possible function of the posterior optic tubercles in the brain of the desert locust Schistocerca gregaria

Migrating desert locusts, Schistocerca gregaria, are able to use the skylight polarization pattern for navigation. They detect polarized light with a specialized dorsal rim area in their compound eye. After multistage processing, polarization signals are transferred to the central complex, a midline-spanning brain area involved in locomotor control. Polarization-sensitive tangential neurons (TB-ne

Preparation of potentially porous, chiral organometallic materials through spontaneous resolution of pincer palladium conformers.

Understanding the mechanism by which advanced materials assemble is essential for the design of new materials with desired properties. Here, we report a method to form chiral, potentially porous materials through spontaneous resolution of conformers of a PCP pincer palladium complex ({2,6-bis[(di-t-butylphosphino)methyl]phenyl}palladium(ii)halide). The crystallisation is controlled by weak hydroge

Adjusting a light dispersion model to fit measurements from vertebrate ocular media as well as ray-tracing in fish lenses.

Color dispersion, i.e., the dependency of refractive index of any transparent material on the wavelength of light, has important consequences for the function of optical instruments and animal eyes. Using a multi-objective goal attainment optimization algorithm, a dispersion model was successfully fitted to measured refractive indices of various ocular media and the longitudinal chromatic aberrati

Non-uniform changes in membrane receptors in the rat urinary bladder following outlet obstruction.

The aim of the present study was to investigate the expression and distribution of membrane receptors after bladder outlet obstruction (BOO). Partial bladder outlet obstruction (BOO) was induced in female rats and bladders were harvested after either 10 days or 6 weeks of BOO. The expression of different receptors was surveyed by microarrays and corroborated by immunohistochemistry and western blo

Obstetric Outcomes in Women With Turner Karyotype EDITORIAL COMMENT

There is concern over the high risk of cardiovascular complications, hypertensive disorders, and other adverse obstetric outcomes among pregnant women with Turner syndrome (TS). A diagnosis of TS is made in some women late in life or not at all. Spontaneous pregnancies are rare in women with TS and are associated with a high rate of complications, especially miscarriage. The use of assisted reprod

Controlled Lateral Positioning of Microparticles Inside Droplets Using Acoustophoresis.

In this paper, we utilize bulk acoustic waves to control the position of microparticles inside droplets in two-phase microfluidic systems and demonstrate a method to enrich the microparticles. In droplet microfluidics, different unit operations are combined and integrated on-chip to miniaturize complex biochemical assays. We present a droplet unit operation capable of controlling the position of m

Population-based data from the Swedish Colon Cancer Registry

Background Evaluating the external validity of clinical trials requires knowledge not only of the study population but also of a relevant reference population. The main aim of this study was to present data from a large, contemporary, population-based cohort of patients with colonic cancer. Methods Data on patients diagnosed between 2007 and 2011 were extracted from the Swedish Colon Cancer Regist

Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: clinical results from a randomised phase-2 study (NordCML006)

We randomised 46 newly diagnosed patients with chronic myeloid leukaemia (median age 56) to receive dasatinib 100mg QD or imatinib 400mg QD and report outcome as an intention-to-treat analysis with 36months follow-up. Early cytogenetic and molecular responses were superior in the dasatinib group, with a tendency that imatinib patients caught up with time. For instance, MR3.0 was reached at 3months