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Health-Related Quality of Life, Dysphagia, Voice Problems, Depression, and Anxiety After Total Laryngectomy
Objectives/Hypothesis: The aims were to determine health-related quality of life (HRQoL), including voice problems, dysphagia, depression, and anxiety after total laryngectomy (TL), and investigate the associations between HRQoL and the late effects. Study Design: Cross-sectional study. Methods: 172 participants having received a TL 1.6 to 18.1 years ago for laryngeal/hypopharyngeal cancer filled
Combined diffusion-relaxometry microstructure imaging : Current status and future prospects
Microstructure imaging seeks to noninvasively measure and map microscopic tissue features by pairing mathematical modeling with tailored MRI protocols. This article reviews an emerging paradigm that has the potential to provide a more detailed assessment of tissue microstructure—combined diffusion-relaxometry imaging. Combined diffusion-relaxometry acquisitions vary multiple MR contrast encodings—
Trust in researchers and researchers' statements in large carnivore conservation
Human–wildlife interactions occur when humans and wildlife overlap in the same landscapes. Due to the growing human population, the number of interactions will continue to increase, and in some cases, develop further into social conflicts. Conflicts may occur between people disagreeing about wildlife conservation or arguing over which wildlife management measures should be taken. Social conflicts
Mission Impossible? : The Moral Discomfort among Swedish and Norwegian Welfare Bureaucrats Encountering Refugees
This article builds on qualitative interviews with employees in Norwegian and Swedish welfare state institutions and explores how they experience and make sense of their work with newly arrived refugees. The task of these street-level bureaucrats was to care for and simultaneously push the refugees to quickly become working taxpayers. Both as fellow human beings and as bureaucrats, however, our in
Convalescent plasma treatment in severely immunosuppressed patients hospitalized with COVID-19: an observational study of 28 cases
BackgroundImmunosuppressed patients are particularly vulnerable to severe infection from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), risking prolonged viremia and symptom duration. In this study we describe clinical and virological treatment outcomes in a heterogeneous group of patients with severe immunosuppression due to various causes suffering from COVID-19 infection, who
The History of Nuclear Medicine
The chapter provides a historic overview of the research in physics and chemistry for the development of radionuclides, radiopharmaceuticals, and instrumentation which have had a major impact for the today’s status of nuclear medicine. During the first half of the 20th century in particular, a number of researchers with relevance to the development of nuclear medicine have been awarded the Nobel P
Imaging in gynecological disease (22) : clinical and ultrasound characteristics of ovarian embryonal carcinomas, non-gestational choriocarcinomas and malignant mixed germ cell tumors
Objective: To describe the clinical and ultrasound characteristics of three types of rare malignant ovarian germ cell tumor: embryonal carcinoma, non-gestational choriocarcinoma and malignant mixed germ cell tumor. Methods: This was a retrospective multicenter study. From the International Ovarian Tumor Analysis (IOTA) database, we identified patients with a histological diagnosis of ovarian embry
The Triple Crisis of Vulnerability : Gendered Violence, Climate Catastrophes and COVID-19 in Asia
In this presentation we focus on men’s violence against the female population both during and in the wake of climate disasters in the Philippines and Vietnam. We examine the legal framework which has been ratified in the two countries to protect individual’s right to live a life without being abused and; how various types of organizations work to prevent and combat specific kinds of violence in th
A side-channel attack on a masked IND-CCA secure saber KEM implementation
In this paper, we present a side-channel attack on a first-order masked implementation of IND-CCA secure Saber KEM. We show how to recover both the session key and the long-term secret key from 24 traces using a deep neural network created at the profiling stage. The proposed message recovery approach learns a higher-order model directly, without explicitly extracting random masks at each executio
Allelic loss in clinically and screening-detected primary hyperparathyroidism
OBJECTIVE: Parathyroid adenomas frequently harbour deletions of genomic DNA at chromosome regions 1p, 6q and 11q. In this study we related clinical characteristics in 56 patients with primary hyperparathyroidism (pHPT) to loss of heterozygosity (LOH) in these chromosome regions.DESIGN: LOH analysis was performed on 56 sporadic parathyroid tumours using a total of 18 microsatellite markers for chro
Naprapathy versus orthopaedic standard care for common musculoskeletal disorders : an 8-year follow-up of a pragmatic randomized controlled trial in Sweden
Background: Musculoskeletal pain is among the most common reasons for seeking care, specialist competence for its treatment in primary care limited and waiting lists for orthopaedics often amongst the longest. Many referrals to orthopaedics do not concern disorders that benefit from surgery. Manual therapy is effective, yet not integrated in national health care systems, and there is a lack of res
Translation, adaptation and testing of an emergency care satisfaction scale in Swedish pediatric emergency departments
Background: Pediatric healthcare today shows a rising demand for research focusing on children’s perspectives on and consumer satisfaction with the nursing care they receive. Therefore, the purpose of this study was to translate and adapt the Consumer Emergency Care Satisfaction Scale (CECSS), a paper-based, self-administered 19-item questionnaire originally developed in the United States and targ
Work, reconfigured
This open issue is published against the background of a major global pandemic. The old ‘normal’ seems far away and undesirable, as a socio-ecological transformation becomes even more urgent. The contributions featured here scrutinize the current trends in the capitalist mode of production and envision the alternative organization of our societies. They examine new configurations of work, to which
Associations between off-label low-dose olanzapine or quetiapine and cardiometabolic mortality
Olanzapine and quetiapine are routinely used off-label at lower doses, though it remains unclear whether treatment is associated with mortality. Here, we examined the associations between low-dose olanzapine/quetiapine, defined as 5 mg/day of olanzapine equivalents (OE) with cardiometabolic mortality in a population-based, longitudinal cohort of individuals who sought specialized psychiatric servi
Relation of Early Monomorphic Ventricular Tachycardia to Long-Term Mortality in ST-Elevation Myocardial Infarction
Early ventricular tachycardia (VT) and ventricular fibrillation (VF) are associated with increased in-hospital mortality but do not influence the long-term prognosis in ST-elevation myocardial infarction (STEMI). Recent data advocate a differential approach to the type of arrhythmia and indicate long-term mortality hazard associated with monomorphic VT. We aimed to evaluate the prognostic value of
Workplace incivility and bystanders’ helping intentions
Purpose: Using observational and experimental designs, the purpose of this study was to explore if the power relation between the offender and the victim of incivility and the level of perceived severity of the incivility were associated with bystanders’ intentions to help when witnessing workplace incivility. Design/methodology/approach: In Study 1, 160 participants completed a questionnaire wher
Development of Novel VEGFR2 Inhibitors Originating from Natural Product Analogues with Antiangiogenic Impact
A novel natural small molecule, voacangine (Voa), has been discovered as a potent antiangiogenic compound. Notably, Voa directly binds the kinase domain of the vascular endothelial growth factor receptor 2 (VEGFR2) and thereby inhibits downstream signaling. Herein, we developed synthetic small molecules based on the unique chemical structure of Voa that directly and specifically target and modulat
Exposure to common-use pesticides, manganese, lead, and thyroid function among pregnant women from the Infants' Environmental Health (ISA) study, Costa Rica
Background: Pesticides and metals may disrupt thyroid function, which is key to fetal brain development. Objectives: To evaluate if current-use pesticide exposures, lead and excess manganese alter free thyroxine (FT4), free triiodothyronine (FT3), and thyroid stimulating hormone (TSH) concentrations in pregnant women from the Infants' Environmental Health Study (ISA). Methods: At enrollment, we de
A method for estimating defects in ferroelectric thin film MOSCAPs
We propose a capacitance measurement scheme that enables quantitative characterization of ferroelectric thin films integrated onsemiconductors. The film defect density is estimated by measurements of the CV hysteresis and frequency dispersion, whereas importantdevice parameters such as memory window and endurance can be extracted by a unidirectional CV method. The simple measurementscheme and the