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Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies

TAR DNA-binding protein-43 (TDP-43) accumulation is the primary pathology underlying several neurodegenerative diseases. Charting the progression and heterogeneity of TDP-43 accumulation is necessary to better characterize TDP-43 proteinopathies, but current TDP-43 staging systems are heuristic and assume each syndrome is homogeneous. Here, we use data-driven disease progression modelling to deriv

An empirically based model of software prototyping : a mapping study and a multi-case study

Context: Prototyping is an established practice within product and user interface design that is also used as a requirements engineering (RE) practice within agile development. Even so, there is a lack of theory on prototyping.Aims: Our main research objective is to support practitioners in improving on their prototyping practices.Method: We have designed a model that describes key aspects of the

DFA as a window into postural dynamics supporting task performance : Does choice of step size matter?

Introduction: Detrended Fluctuation Analysis (DFA) has been used to investigate self-similarity in center of pressure (CoP) time series. For fractional gaussian noise (fGn) signals, the analysis returns a scaling exponent, DFA-α, whose value characterizes the temporal correlations as persistent, random, or anti- persistent. In the study of postural control, DFA has revealed two time scaling region

Radio Frequency InGaAs MOSFETs

III-V-based Indium gallium arsenide is a promising channel material for high-frequency applications due to its superior electron mobility property. In this thesis, InGaAs/InP heterostructure radio frequency MOSFETs are designed, fabricated, and characterized. Various spacer technologies, from high dielectric spacers to air spacers, are implemented to reduce parasitic capacitances, and fT/fmax are

Detection of Inflammasome Activation in Murine Bone Marrow-Derived Macrophages Infected with Group A Streptococcus

Inflammasomes are large multiprotein complexes that assemble mainly in innate immune cells after detection of microbial or sterile insults. Activation of inflammasomes is a key proinflammatory event during infection, and many pathogens have evolved specific evasion mechanisms to evade or inhibit inflammasome activation. One such pathogen is the common bacterium group A Streptococcus (GAS), which c

Large-scale assessment of polyglutamine repeat expansions in Parkinson disease

OBJECTIVES: We aim to clarify the pathogenic role of intermediate size repeat expansions of SCA2, SCA3, SCA6, and SCA17 as risk factors for idiopathic Parkinson disease (PD).METHODS: We invited researchers from the Genetic Epidemiology of Parkinson's Disease Consortium to participate in the study. There were 12,346 cases and 8,164 controls genotyped, for a total of 4 repeats within the SCA2, SCA3,

Unga universitetsstudenters kunskaper om sex, attityder till sex och cybersexualitet

The primary objective of this investigation entailed examining the sexual knowledge, attitudes, and behaviors of young adults aged 18-29 who were enrolled at Lund University. Additionally, the study sought to determine whether a statistical relationship exists between knowledge, attitudes, and practices. Data collection employed a web-based survey method, sent out to a randomized sample of 1,000 s

Varför är den svenska kronan så svag mot euron?

Kronan har försvagats mot euron under tio års tid. Detta har på sistone utlöst enintensiv debatt. Deprecieringen har tagits som intäkt för att Sverige bör ersättakronan med euron. Vi studerar här faktorerna bakom kronförsvagningen. Vårslutsats är att den i huvudsak beror på att inflationen i Sverige varit högre äni euroområdet. Denna process är kopplad till en mer expansiv penningpolitik iSverige.

Beräkningar av energi och klimatpåverkan kopplat till stomval och köldbryggor vid anslutningar.

Populärvetenskaplig sammanfattning Energi- och klimatberäkningar kopplat till olika byggmaterial och värmeförluster som uppkommer i anslutningar där byggdelar möts. Klimat och miljö har under de senaste åren blivit alltmer uppmärksammat och äntligen följer Boverket med! Med den nya lagen som trädde i kraft under 2021, om att undersöka klimatpåverkan hos nybyggda hus har man satt byggbranschens mConsidering the current energy and climate crisis, it is important to examine how the impact on these can be managed and reduced within the building sector. One of the objectives of this study is to analyze the impact of several typical thermal bridges for a single-family house on the energy use and show how these vary depending on the choice of framing system. The framing systems studied are CLT,

Nanofluidic gas/liquid switching utilizing a nanochannel open/close valve based on glass deformation

There has been much progress in the field of nanofluidics, and novel applications, such as single-cell analysis, have been achieved. In such cases, controlling the location of the gas/liquid interface is vital and partial hydrophobic modification is frequently used to pin the position of this interface. However, because the fluid manipulating pressure in such devices is comparable to the Laplace p

Mission-Oriented Innovation Districts : Towards challenge-led, place-based urban innovation

In recent years, there has been rapidly growing interest in Innovation Districts (ID) in urban policy and practice. IDs are touted as catalysts for innovation and economic development involving a wide range of stakeholders often in under-performing neighbourhoods or precincts. Despite the appeal, critique is forming around their linear understanding of innovation, the narrow focus of economic goal