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The viscoelastic signature underpinning polymer deformation under shear flow

Entangled polymers are deformed by a strong shear flow. The shape of the polymer, called the form factor, is measured by small angle neutron scattering. However, the real-space molecular structure is not directly available from the reciprocal-space data, due to the phase problem. Instead, the data has to be fitted with a theoretical model of the molecule. We approximate the unknown structure using

A colorful death : A study of the social life of colors in Late Bronze Age grave goods

The study of burials can include, among other things, examinations of grave goods, architecture, osteological and organic remains, context and location, socio-religious and ritual importance, sacred landscape, socio-economic relevance, and so on. One area that has not been investigated in depth regarding the objects placed in the graves is the aspect of color: does their color in general or specifi

Addition of n-Alcohols Induces a Variety of Liquid-Crystalline Structures in Surfactant-Rich Cores of Dispersed Block Copolymer/Surfactant Nanoparticles

Poly(acrylamide)-b-complex salts made from a symmetric poly(acrylate-b-acrylamide) block copolymer, where the acrylate charges are neutralized by cationic surfactant counterions, form kinetically stable aqueous dispersions of hierarchical aggregates with a liquid-crystalline complex salt core and a diffuse hydrated shell. By the addition of suitable amounts of long-chain alcohols, such as octanol

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ABSTRACT Introduction: Scientists from many disciplines have studied population, church and burials from the Early Medieval churchyard Västerhus/Westerhus in Middle Sweden. Archaeology, anthropology, odontology and demography of this population have been investigated. The present project group has, above all, investigated teeth, bones and bone chemistry. But also many archaeological questions have

Pirqei deRabbi Eliezer : Structure, Coherence, Intertextuality

In Pirqei deRabbi Eliezer: Structure, Coherence, Intertextuality Katharina E. Keim offers a description of the literary character of Pirqei deRabbi Eliezer, an enigmatic work of the late-eighth-to-early-ninth centuries CE. Katharina E. Keim explores the work’s distinctive literary features through an analysis of its structure and coherence. These literary features, when taken together with the wor

Harnessing androgen receptor pathway activation for targeted alpha particle radioimmunotherapy of breast cancer

Purpose: The impact of androgen receptor (AR) activity Results: D-Norgestrel and DHT activated the AR pathway, in breast cancer biology is unclear. We characterized and while 17b-Estradiol did not. Competitive binding for AR tested a novel therapy to an AR-governed target in breast protein showed similar affinity between DHT and D-Norges-cancer. trel, indicating direct AR–ligand interaction. In vi

Uncertainty quantification, propagation and characterization by Bayesian analysis combined with global sensitivity analysis applied to dynamical intracellular pathway models

Motivation: Dynamical models describing intracellular phenomena are increasing in size and complexity as more information is obtained from experiments. These models are often over-parameterized with respect to the quantitative data used for parameter estimation, resulting in uncertainty in the individual parameter estimates as well as in the predictions made from the model. Here we combine Bayesia

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes

Transient oligomeric species formed during the aggregation process of the 42-residue form of the amyloid-β peptide (Aβ42) are key pathogenic agents in Alzheimer’s disease (AD). To investigate the relationship between Aβ42 aggregation and its cytotoxicity and the influence of a potential drug on both phenomena, we have studied the effects of trodusquemine. This aminosterol enhances the rate of aggr

Proteogenomic characterization of patient-derived xenografts highlights the role of REST in neuroendocrine differentiation of castration-resistant prostate cancer

Purpose: An increasing number of castration-resistant prostate cancer (CRPC) tumors exhibit neuroendocrine (NE) features. NE prostate cancer (NEPC) has poor prognosis, and its development is poorly understood. Experimental Design: We applied mass spectrometry–based proteomics to a unique set of 17 prostate cancer patient–derived xenografts (PDX) to characterize the effects of castration in vivo, a

The language of the press in Soviet time and post-Soviet Russia: Creation of the citizen role through newspaper discourse

The Russian media system was during most of the 20th century part of the state institutions. During glasnost and perestroika, the media became gradually more independent of the state. However, the subsequent apex of journalistic freedom in the late 1980s and the early 1990s was followed by stagnation and a pronounced democratic setback following Putin’s accession to power. Despite this, the findin