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Late complications of childhood acute lymphoblastic leukaemia (ALL), with special reference to hormone secretion, cardiovascular risk and bone health

An increased prevalence of cardiovascular (CV) risk factors and cardiac abnormalities has been shown among adult GH deficient ALL survivors subjected to cranial irradiation. The ALL treatment includes many known risk factors for low bone mineral density (BMD), but little is known about pituitary insufficiencies, except for GH deficiency. In study I we evaluated the impact of 2 years GH therapy on

The COLOFOL trial: study design and comparison of the study population with the source cancer population.

The COLOFOL trial, a prospective randomized multicenter trial comparing two follow-up regimes after curative surgical treatment for colorectal cancer, focuses on detection of asymptomatic recurrences. This paper aims to describe the design and recruitment procedure in the COLOFOL trial, comparing demographic characteristics between randomized patients and eligible patients not included in the stud

The Global Prevalence of Infections in Urology Study: A Long-Term, Worldwide Surveillance Study on Urological Infections.

The Global Prevalence of Infections in Urology (GPIU) study is a worldwide-performed point prevalence study intended to create surveillance data on antibiotic resistance, type of urogenital infections, risk factors and data on antibiotic consumption, specifically in patients at urological departments with healthcare-associated urogenital infections (HAUTI). Investigators registered data through a

Ambiguity Domain Definitions and Covariance Function Estimation for Non-Stationary Random Processes in Discrete Time

The ambiguity domain plays a central role in estimating the time-varying spectrum of a non-stationary random process in continuous time, since multiplication in this domain is equivalent with estimating the covariance function of the random process using an intuitively appealing estimator. For processes in discrete time there exists a corresponding covariance function estimator. The ambiguity doma

Elevated infection parameters and infection symptoms predict an acute coronary event.

BACKGROUND: The etiology and significance of flu-like symptoms often appearing before myocardial infarction should be clarified. METHODS: In a case-control study of 323 matched controls and a random sample of 110 out of 351 cases the presence of infection symptoms during the preceding four weeks before admission were asked and blood samples taken. RESULTS: Enterovirus (EV), herpes simplex virus (H

Experimental and theoretical energy levels, transition probabilities and radiative lifetimes in YbIII

The analysis of the spectrum of Yb rn has been extended allowing us to establish 11 new energy level values. In addition, radiative lifetimes of two excited states of Yb III have been measured for the first time using time-resolved laser-induced fluorescence following two-photon excitation. The good agreement between experimental results and semi-empirical calculations performed with the relativis

Noise optimization of an inductively degenerated CMOS low noise amplifier

This paper presents a technique for substantially reducing the noise of a CMOS low noise amplifier implemented in the inductive source degeneration topology. The effects of the gate induced current noise on the noise performance are taken into account, and the total output noise is strongly reduced by inserting a capacitance of appropriate value in parallel with the amplifying MOS transistor of th

Influence of a lifestyle intervention among persons with a psychiatric disability: a cluster randomised controlled trail on symptoms, quality of life and sense of coherence.

Aims and objectives. The aim of this study was to investigate how a lifestyle intervention programme influences psychiatric and psychosocial factors among persons with psychiatric disabilities. Background. Persons with psychiatric disabilities often suffer from a simultaneous physical health problem, where circulatory disorder, hyperlipideamia, digestive disease, diabetes mellitus and obesity are

Time-resolved x-ray spectroscopy of optical-field-ionized plasmas

The time-dependent soft X-ray emission of helium and nitrogen plasmas generated by optical-field ionization is reported. The experiments were carried out by focusing pulses of the high-power Ti:sapphire laser of the Lund Institute of Technology (lambda = 796 nm, pulse duration 150 fs, pulse energy 150 mJ) to a 50-mu m diameter spot close to a nozzle, using He and N-2 as target gases. The emission

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Objective: Oesophageal atresia is an congenital anomali with incidence of 1/3000-1/4500 live births. The results of reconstructive surgery has improved greatly, to 80-92% survival reported in the last two decades. The aim of this study was to determine the incidence of oesophageal atresia in Iceland and to evaluate the results of operations at the Department of Pediatric surgery at The Children's

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BACKGROUND: Androgen insensitivity is caused by mutations in the androgen receptor gene, and is a common etiological factor to ambiguous genitalia in the newborn. This article discusses the role of androgens in sex differentiation, the structure and function of the androgen receptor, the genetic background to androgen insensitivity as well as clinical aspects. MATERIAL AND METHODS: The article is

Use of the harmonic scalpel versus conventional haemostatic techniques in patients with Grave disease undergoing total thyroidectomy: a prospective randomised controlled trial.

INTRODUCTION: Thyrotoxicosis is often considered to be the most difficult thyroid operation because of the high vascularisation and the risk of bleeding. The conventional haemostatic technique in thyroidectomy today include knot tying and electrocoagulation. The introduction of the harmonic scalpel (HS) has led to further research if the use of the HS has any benefits in thyroid surgery. To our kn