Protein-DNA interactions are involved in many biological processes essential for gene expression and regulation. To understand the molecular mechanisms of protein-DNA recognition, it is crucial to analyze and identify DNA-binding residues of protein-DNA complexes. Here, we proposed a novel descriptor shape string and another two related features shape string PSSM and shape string pair composition

Images are created not in a vacuum but in hidden yet potent, contending political forces. The missionary endeavour of the nineteenth century was not exempt from this reality. Images became integral to missionary publications and shaped the metropolitan imagination regarding the colonised people, their religion, gods, and rituals. Displaying the colonies and their people was of utmost importance as

Segmentation of grey matter in magnetic resonance images of the spinal cord is an important step in assessing disease state in neurological disorders such as multiple sclerosis. However, manual delineation of spinal cord tissue is time-consuming and susceptible to variability introduced by the rater. We present a novel segmentation method for spinal cord tissue that uses fully convolutional encode

Channel fabrication technology has become increasingly important for microfluidic and nanofluidic devices. In particular, glass channels have high chemical and physical stability, high optical transparency, and ease of surface modification, so that there is increasing interest in glass microfluidic devices for chemical experiments in microfluidics and nanofluidics. For the fabrication of glass cha

Many studies have demonstrated that shape string is an extremely important structure representation, since it is more complete than the classical secondary structure. The shape string provides detailed information also in the regions denoted random coil. But few services are provided for systematic analysis of protein shape string. To fill this gap, we have developed an accurate shape string predi

Numerous methods for predicting c-turns in proteins have been developed. However, the results they generally provided are not very good, with a Matthews correlation coefficient (MCC) ≤0.18. Here, an attempt has been made to develop a method to improve the accuracy of γ-turn prediction. First, we employ the geometric mean metric as optimal criterion to evaluate the performance of support vector mac

This thesis focuses on various aspects in terahertz quantum cascade lasers such as high temperature performances, electrical instabilities and chaos. In the first part of the thesis, an introduction to the topic and the non equilibrium Green's function package applied is given with particular emphasise on the inhomogeneous domain model and the chaos theory. In addition, new results regarding the h

It is often a challenge for a child to communicate their pain, and their possibilities to do so should be strengthened in healthcare settings. Digital self-assessment provides a potential solution for person-centered care in pain management and promotes child participation when a child is ill. A child's perception of pain assessment differs when it is assessed using digital or analog formats. As w

Shakespeare's Hamlet has been retold in children's versions several times in Sweden in recent years. It was the subject of the first episode of the children's television programme På teatern [At the Theatre], written and directed by Christina Nilsson for SVT in 2001–2002, where Shakespearean actors meet their child or grandchild backstage after a performance to tell and partly enact the story of t

Objective: This study aimed to evaluate the 9-month cost and health-related quality of life (HRQOL) outcomes of resistance versus viral load testing strategies to manage virological failure in low-middle income countries. Methods: We analyzed secondary outcomes from the REVAMP clinical trial: a pragmatic, open label, parallel-arm randomized trial investigating resistance versus viral load testing

INTRODUCTION: Decreased dopaminergic activity - as reflected by lower levels of the major metabolite homovanillic acid (HVA) in cerebrospinal fluid (CSF) - may be involved in the pathophysiology of attempted suicide. An inverse association has also been found between dopaminergic activity and clinical symptoms of depression and anxiety in non-suicidal individuals. The aim of this study was to asse

Despite the passing in 2015 of UNSCR 2250 on Youth, Peace, and Security, the study of young people’s political agency in conflict, and the possibilities for empowerment and transformative change, remains sparse. This article investigates generative processes of youth political agency in the Syrian war since 2011 and under what conditions conflict has politically empowered/disempowered youth. Drawi

Conformal prediction has been proposed as a more rigorous way to define prediction confidence compared to other application domain concepts that have earlier been used for QSAR modeling. One main advantage of such a method is that it provides a prediction region potentially with multiple predicted labels, which contrasts to the single valued (regression) or single label (classification) output pre

Mycobacterium, the most common disease-causing genus, infects billions of people and is notoriously difficult to treat. Understanding the subcellular localization of mycobacterial proteins can provide essential clues for protein function and drug discovery. In this article, we present a novel approach that focuses on local sequence information to identify localization motifs that are generated by

Vi lever i en tid då arbetslivet – både i Sverige och globalt – genomgår storaförändringar och står inför stora utmaningar. Arbetslivsforskning har därför enstor samhällelig relevans. Men hur står det egentligen till med arbetslivsforskningen vid Lunds universitet? Hur många arbetslivsforskare finns det och var någonstans håller de hus? Och hur ser de på förutsättningarna för att bedriva arbetsliv

BACKGROUND: The Xpert MTB/RIF Ultra (Xpert-Ultra) assay provides timely results with good sensitivity and acceptable specificity with stool specimens in children for bacteriological confirmation of tuberculosis (TB). This study aims to optimize the Simple One-Step (SOS) stool processing method for testing stool specimens using the Xpert-Ultra in children and adults in selected health facilities in

Background: Persistent breathlessness is debilitating and increases in prevalence with advanced age and at end of life. This study aimed to evaluate any relationship between self-reported global impressions of change (GIC) in perceived health and breathlessness in older men.Design: Cross-sectional study of 73-year-old Swedish men in the VAScular and Chronic Obstructive Lung disease study. A postal

After World War II and prior to the financial deregulation of the 1980s, monetary policy in Sweden as well as in other western European countries rested chiefly on a system of far- reaching non-market-oriented controls of credit flows and interest rates. How was monetary policy conducted in such an environment of financial repression, where the central bank was unable to rely on traditional moneta