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Heart rate and premature atrial contractions at 24hECG independently predict atrial fibrillation in a population-based study

BACKGROUND: Low resting heart rate and premature atrial contractions (PACs) predict incident atrial fibrillation (AF) and could be interdependent, since PACs occur in the gaps between normal beats.OBJECTIVE: To study the association between low heart rate at 24hECG, PACs and incident AF in a prospective population-based cohort.METHODS: In the Malmö Diet and Cancer study, 24hECGs were performed in

CHA2DS2VASc score and adverse outcomes in middle-aged individuals without atrial fibrillation

AIMS: The CHA2DS2VASc score is used to evaluate the risk of thromboembolic events in patients with non-valvular atrial fibrillation. We assessed the prognostic yield of CHA2DS2VASc for new-onset atrial fibrillation, cardiovascular morbidity and mortality in a non-atrial fibrillation population.METHODS: We analysed a population-based cohort of 22,179 middle-aged individuals with (n = 3542) and with

Monitoring of cerebral oximetry in patients with postural orthostatic tachycardia syndrome

AIMS : Postural orthostatic tachycardia syndrome (POTS) is a disorder of unknown aetiology characterized by orthostatic intolerance and tachycardia with diverse other symptoms, including neurocognitive deficits. Cerebral oximetry non-invasively measures cerebral tissue saturation (SctO2) and has been shown to be informative in syncope evaluation. We aimed to assess SctO2 in POTS patients and those

Overview of some feedback-&control systems at synchrotron SolEIL

This paper gives an overview of some feedback & control systems at Synchrotron SOLEIL that are in use or in development today. Beam stability is crucial and adressed in all SOLEIL aspects; Fast Orbit Feedback is a multi-input multi-output control system made to stabilize beam position perturbations in the low- & high frequency band. In addition, active RF cavities are used to maintain stab

From analogue to digital a study of documentation methods during an excavation of the Neolithic flint mines at Pilbladet, Sweden

The ‘digital turn’ in archaeology has resulted in documentation, analysis, visualization and repository requirements becoming increasingly digital in recent years. However, we are only at the beginning of understanding how the shift from analogue to digital affects archaeological interpretation, as attention has mainly been directed towards technological aspects. However, how archaeology is execut

Modified Peritoneal Flap Hernioplasty Versus Retromuscular Technique for Incisional Hernia Repair : a Retrospective Cohort Study

Background and Aims: We present an open retromuscular mesh technique for incisional hernia repair, the modified peritoneal flap hernioplasty, where the fascia is sutured to the mesh and the hernia sac utilized for anterior mesh coverage. The aim was to describe the modified peritoneal flap hernioplasty technique and to compare it to a retromuscular repair, without component separation, regarding s

From ancient herbs to modern drugs : In search of alternatives for cancer therapy

Breast cancer is the major cause of deaths related to cancer for women worldwide. Although much is known about this malignancy, extensive research is still needed to gain complete understanding of the complexity of the disease. The inter and intra tumor heterogeneity is an important trait of breast cancer. The intratumor heterogeneity is reflected in sub-populations of cancer cells that appear to Breast cancer is the major cause of deaths related to cancer for women worldwide. Although much is known about this malignancy, extensive research is still needed to gain complete understanding of the complexity of the disease. The inter and intra tumor heterogeneity is an important trait of breast cancer. The intratumor heterogeneity is reflected in sub-populations of cancer cells that appear to

The origin of stellar populations in the Galactic bulge from chemical abundances

In this work, we study the formation and chemical evolution of the Galactic bulge with particular focus on the abundance pattern ([Mg/Fe] versus [Fe/H]), metallicity, and age distribution functions. We consider detailed chemical evolution models for the Galactic bulge and inner disc, with the aim of shedding light on the connection between these components and the origin of bulge stars. In particu

Adherence to childhood cancer treatment : A prospective cohort study from Northern Vietnam

Objectives Global incidence and attention to childhood cancer is increasing and treatment abandonment is a major cause of treatment failure in low-and middle-income countries. The purpose of this study was to gain an understanding of factors contributing to non-adherence to treatment. Design A prospective cohort study with 2 year follow-up of incidence, family-reported motives and risk factors. Se

Follicular Lymphoma : Recent and Emerging Therapies, Treatment Strategies, and Remaining Unmet Needs

Follicular lymphoma (FL) is a heterogeneous disease with varying prognosis owing to differences in clinical, laboratory, and disease parameters. Although generally considered incurable, prognosis for early- and advanced-stage disease has improved because of therapeutic advances, several of which have resulted from elucidation of the biologic and molecular basis of the disease. The choice of treatm

Plasma homocysteine in renal failure

Plasma homocysteine in three different groups of patients with chronic renal failure (one group without dialysis, one with CAPD and one with hemodialysis) was increased compared to controls. Another group of patients with slightly reduced renal dysfunction (normal serum creatinine but reduced glomerular filtration rate) did not, however, show increase of plasma homocysteine. The clearance of homoc

A CD146 FACS Protocol Enriches for Luminal Keratin 14/19 Double Positive Human Breast Progenitors

Human breast cancer is believed to arise in luminal progenitors within the normal breast. A subset of these are double positive (DP) for basal and luminal keratins and localizes to a putative stem cell zone within ducts. We here present a new protocol based on a combination of CD146 with CD117 and CD326 which provides an up to thirty fold enrichment of the DP cells. We show by expression profiling

Prevalence of Sports-Related Injuries and Illnesses in Paralympic Athletes

BACKGROUND: With increased participation in Paralympic sports, the burden of sports-related injuries and illnesses may increase. However, there is limited knowledge about the epidemiology of sports-related injuries and illnesses in Paralympic sports (SRIIPS).OBJECTIVE: To describe among Swedish Paralympic athletes the 1-year retrospective period prevalence of severe SRIIPS and the point prevalence

Luminescence Spectroscopy For Biomedical Applications

This work presents optical methods utilizing visible light for characterization of biological tissue during diagnostics and treatment processes. The main aim has been to improve the therapeutic outcome of treatment modalities in in vivo studies. An optical probe instrument based on fluorescence/reflectance spectroscopy was developed for noninvasive monitoring of photosensitizerconcentration in the