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Studies on chondrocyte integrins and mechanical signaling

Popular Abstract in Swedish Brosk är en typ av vävnad som finns på många olika ställen i vår kropp. Karakteristiskt för brosk är att det är mycket hållfast samtidigt som det medger en hög grad av flexibilitet. Ledbrosket är det tunna brosklager som klär kortändarna på benen i skelettet. Dess uppgift i leden är att fungera som stötdämpare för att skydda det underliggande benet samt att utgöra den gIntegrins are a family of cell surface receptors known to bind matrix proteins and to mediate signals such as mechanical signals between the cell and the surrounding matrix. We have studied integrins that are expressed by chondrocytes, with specific focus on the integrins that interact with the cartilage matrix protein collagen type II. It was found that chondrocytes isolated from articular cartil

Structural and physicochemical studies on metal and porphyrin binding by the Bacillus subtilis ferrochelatase

The enzyme ferrochelatase (EC 4.99.1.1) is the terminal enzyme in the biosynthetic pathway of heme b and catalyzes the insertion of Fe(II) into protoporphyrin IX. In this dissertation ferrochelatase from Bacillus subtilis was studied. A new purification method via inclusion bodies was developed that enabled simple purification of recombinant enzyme without tags or modifications that might affect t

The Generalized Signal Detection Theory

Signal detection theory (SDT) and the Dual Process SDT (Yonelinas, 1994) are currently the most influential accounts of item variability in recognition memory. However, neither provides a sufficient account of differences in the familiarity distributions. Instead, this phenomenon is accounted for by the idea of encoding variability (Wixted, 2007) or an additional retrieval process (Yonelinas, 2001

Cooling vest incorporated with phase change materials (PCMs): how much benefit is there?

The aim of this study was to investigate torso cooling benefit of various PCM vests in a simulated warm environment (Ta= 34 °C, RH=56 %, Va=0.4 m/s). A pre-wetted cotton torso fabric skin was used to simulate sweating on a thermal manikin (Tmanikin=34 °C). Six conditions were tested: nude fabric skin (Fabric Skin), Vest A without (VA) and with frozen gels with a melting temperature (Tm) of 0 °C (V