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Compact single-shot d-scan setup for the characterization of few-cycle laser pulses

We present a compact implementation of the ultrashort pulse measurement technique based on dispersion scans (d-scan), allowing single-shot measurement of few-cycle pulses. The main novelty in our design, making our setup extremely compact and simple, is the use, after a prism, of a spherical mirror in an off-axis geometry. The intentionally introduced strong astigmatism makes it possible to image

Why do horseflies need polarization vision for host detection? Polarization helps tabanid flies to select sunlit dark host animals from the dark patches of the visual environment

Horseflies (Tabanidae) are polarotactic, being attracted to linearly polarized light when searching for water or host animals. Although it is well known that horseflies prefer sunlit dark and strongly polarizing hosts, the reason for this preference is unknown. According to our hypothesis, horseflies use their polarization sensitivity to look for targets with higher degrees of polarization in thei

Hypoxia and hypoxia-inducible factors in neuroblastoma

Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2. Both HIF-1α and HIF-2α expression levels have been shown to correlate to patient outcome in various tumor forms and in neuroblastoma, a solid childh

Predictors of risk for sudden death in childhood hypertrophic cardiomyopathy : The importance of the ECG risk score

Objective To establish which risk factors are predictive for sudden death in hypertrophic cardiomyopathy (HCM) diagnosed in childhood. Methods A Swedish national cohort of patients with HCM diagnosed 2 years (n=100), and features significantly more common in SD/CA group were further analysed with univariate and multivariate Cox hazard regression in the total cohort. Results Ranked according to rel

CD11b and CD200 on circulating monocytes differentiate two angiographic subtypes of polypoidal choroidal vasculopathy

Purpose: To investigate surface expression of CD11b and CD200 on circulating monocytes in patients with polypoidal choroidal vasculopathy (PCV). Methods: This was a prospective case-control study of patients with PCV (n = 27), age-matched healthy controls (n = 27), and patients with neovascular AMD (n = 49). All participants underwent a comprehensive ocular examination. Fluorescein and indocyanine

Translation, Cross-Cultural Adaptation, and Validation of the Activity Rating Scale for Disorders of the Knee

Background: The Activity Rating Scale (ARS) for disorders of the knee evaluates the level of activity by the frequency of participation in 4 separate activities with high demands on knee function, with a score ranging from 0 (none) to 16 (pivoting activities 4 times/wk). Purpose: To translate and cross-culturally adapt the ARS into Swedish and to assess measurement properties of the Swedish versio

SOX5/6/21 prevent oncogene-driven transformation of brain stem cells

Molecular mechanisms preventing self-renewing brain stem cells from oncogenic transformation are poorly defined. We show that the expression levels of SOX5, SOX6, and SOX21 (SOX5/6/21) transcription factors increase in stem cells of the subventricular zone (SVZ) upon oncogenic stress, whereas their expression in human glioma decreases during malignant progression. Elevated levels of SOX5/6/21 prom

Treatment of synthetic textile wastewater containing dye mixtures with microcosms

The aim was to assess the ability of microcosms (laboratory-scale shallow ponds) as a post polishing stage for the remediation of artificial textile wastewater comprising two commercial dyes (basic red 46 (BR46) and reactive blue 198 (RB198)) as a mixture. The objectives were to evaluate the impact of Lemna minor L. (common duckweed) on the water quality outflows; the elimination of dye mixtures,

On the Aggregation of Cereal β-Glucan and its Association with other Biomolecules : A Study using Asymmetric Flow Field-Flow Fractionation (AF4)

During recent years, numerous studies have shown the ability of dietary fiber toprotect the colon from disease and to improve intestinal health. Beneficial healtheffects, such as the lowering of blood cholesterol levels and a reduction in the risk of coronary heart disease, are often directly related to cereal β-glucan, one of the major components of dietary fiber found in oat and barley. No defin

Distinct 18F-AV-1451 tau PET retention patterns in early- and late-onset Alzheimer's disease

Patients with Alzheimer's disease can present with different clinical phenotypes. Individuals with late-onset Alzheimer's disease (465 years) typically present with medial temporal lobe neurodegeneration and predominantly amnestic symptomatology, while patients with early-onset Alzheimer's disease (565 years) exhibit greater neocortical involvement associated with a clinical presentation including

Validation of a Unilateral Cleft Lip Surgical Outcomes Evaluation Scale for Surgeons and Laypersons

Background: A standardized evaluation tool is needed for the assessment of surgical outcomes in cleft lip surgery. Current scales for evaluating unilateral cleft lip/nose (UCL/N) aesthetic outcomes are limited in their reliability, ease of use, and application. The Unilateral Cleft Lip Surgical Outcomes Evaluation (UCL SOE) scale measures symmetry of 4 components and sums these for a total score.

Association analysis identifies 65 new breast cancer risk loci

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of

Obstacle contained system (OCS) design method and its application in valve core orifice design of pilot-control globe valve

With the development of the society and the times, traditional parametric design methods are witnessing a severe challenge due to the more and more complex physical systems. Thus, developing novel parametric analysis methods is very important for dealing with complex physical systems, refining useful parameters from numerous data, and proposing accurate prediction formulas. A spring slider system,

An economic comparison of dedicated crops vs agricultural residues as feedstock for biogas of vehicle fuel quality

The vast majority of the biofuels presently used in the EU are so called first generation biofuels produced from crops. Concerns of food security, displacement of food crop production and indirect land use change (iLUC) has led to the introduction of measures to reduce the use of first generations biofuels and promote so called advanced biofuels based on feedstock that does not compete with food/f

Using Typical and Extreme Weather Files for Impact Assessment of Climate Change on Buildings

Considering climate change and assessing its impacts is challenging due to dealing with large data sets and uncertainties. This paper discusses an approach for the impact assessment of climate change based on synthesizing weather data sets out of several climate scenarios, in a way to generalize the assessment despite of the existence of climate uncertainties. The is based on creating one-year wea

Minnen av ett inbördeskrig. Jubileer och monument i Gettysburg 1863–2017

Artikel om jubileer och monument i anslutning till amerikanska inbördeskriget. I fokus står olika högtidlighållanden och statyer i Gettysburg, där ett av de avgörande slagen stod 1863. I analysen inkluderas flera olika förhållningssätt till minnesarbetet över det, från betydelsen av de döda kropparna och begravningsplatser via uppföranden av monument och ökad turisttillströmning till betydelsen av