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Association between anemia and stroke with its subtypes in adults : Insights from NHANES 2005–2016 and Mendelian randomization analyses
Stroke and anemia are both prevalent conditions with significant health burdens, yet their bidirectional relationship remains poorly understood. Anemia affects up to 29 % of stroke patients and is associated with increased worse outcomes. However, the causal nature of this association, particularly concerning different anemia subtypes, remains controversial, and there is a lack of clear targets an
Loss of empathy is a key problem in people with frontotemporal dementia – our research shows what’s happening in the brain
A large-scale multi-centre study characterising atrophy heterogeneity in Alzheimer's disease
Previous studies identified atrophy-based Alzheimer's disease(AD) subtypes linked to distinct clinical symptoms, but their consistency across subtyping approaches remains unclear. This large-scale study evaluates subtype concordance using two data-driven approaches. In this work, we analyzed data from n=10,011 patients across 10 AD cohorts spanning Europe, the US, and Australia, extracting regiona
Distance-based assessment of spatial artifact extension in the prostate from fiducial markers in diffusion-weighted magnetic resonance imaging
Background: Fiducial markers in image-guided prostate cancer radiotherapy reduce geometric uncertainty during daily patient setup and enable assessment of target position changes. Diffusion-weighted magnetic resonance imaging (MRI) for target delineation improves prostate cancer localization, beneficial for intraprostatic focal boost. Artifacts from fiducial markers on prostate diffusion-weighted
Faced with new tariffs and a truculent Trump, Japan and South Korea toe a cautious line
How dramatic daily swings in oxygen shaped early animal life – new study
Inter-reader agreement of quantitative FDG PET/CT biomarkers in lymphoma : a multicentre evaluation of MTV, TLG and Dmax
Background: The Deauville score is a key prognostic factor in Hodgkin lymphoma (HL) and diffuse large B-cell lymphoma (DLBCL) during interim and end-of-treatment PET/CT evaluations. However, additional measurements, particularly at baseline, such as metabolic tumour volume (MTV), total lesion glycolysis (TLG), and the maximum distance between hypermetabolic lymphoma lesions (Dmax) may offer enhanc
Sensory and physical characterization of cream cheese and baobab spreads containing seaweed (Alaria esculenta) and effect of LAB fermentation on consumer acceptance
In Western countries, brown seaweeds as a component in a meal are not well-accepted, mainly due to their ‘fishy’ and ‘ocean-like’ flavors. Therefore, ameliorating these notes might be essential for achieving wider acceptance of minimally processed seaweeds as ingredients in foods. In this study, brown seaweed Alaria esculenta (Badderlocks) was fermented with Lactiplantibacillus plantarum (formerly
Investigation of turbulent flow in a Schwarz Diamond monolith using MRI and CFD
Particle packings are widely used in process applications, yet often have poor flow distribution due to random channel geometries. Regular channels can now be realised using 3D-printing, where tuneable channel morphology also offers the possibility of promoting vortices and fluctuating motion to enhance heat and mass transfer. Detailed visualisation experiments are required to understand hydrodyna
China’s dwindling marriage rate is fuelling demand for brides trafficked from abroad
Physics-informed 4D x-ray image reconstruction from ultra-sparse spatiotemporal data
The unprecedented x-ray flux density provided by modern x-ray sources offers new spatiotemporal possibilities for x-ray imaging of fast dynamic processes. Approaches to exploit such possibilities often result in either (i) a limited number of projections or spatial information due to limited scanning speed, as in time-resolved tomography, or (ii) a limited number of time points, as in stroboscopic
Poverty, Incentive Alignment and Resilience to Economic Shrinking - A Conceptual Proposal
Recent research has highlighted the importance of reducing economic shrinking—periods of negative per capita growth—for long-term development. Building on this literature, this chapter proposes a new framework explicitly connecting the dynamics of poverty eradication to the dynamics of resilience to economic shrinking. It argues that a key driver of this resilience is the alignment of incentives b
Automatic Segmentation of Medial Temporal Lobe Subregions in Multi-Scanner, Multi-Modality Magnetic Resonance Imaging of Variable Quality
Volumetry of subregions in the medial temporal lobe (MTL) computed from automatic segmentation in MRI can track neurodegeneration in Alzheimer's disease. However, poor quality MR images can lead to unreliable segmentation of MTL subregions. Considering that different MRI contrast mechanisms and field strengths (jointly referred to as “modalities” here) offer distinct advantages in imaging differen
The Role of Other Major Postoperative Complications in Determining Outcomes of Acute Kidney Injury After Coronary Artery Bypass Surgery
Background: Acute kidney injury (AKI) is a common complication of coronary artery bypass surgery (CABG) and is associated with worse outcomes. It remains unclear whether AKIs impact on prognosis can be attributed to other concurrent major complications. Methods: This retrospective cohort study included consecutive patients undergoing isolated CABG at a single nationwide center from 2001 to 2020. P
Uncovering the initial nucleation process during rapid heating of Fe-Co-Nb-B metallic glasses
Fe-based metal amorphous nanocomposites, consisting of dispersed nanocrystallites within an amorphous metallic glass matrix, are used as low-loss soft-magnetic components in energy conversion devices. The nanocrystallites are formed by partial devitrification of the amorphous matrix and the properties of the composite are a result of the devitrification process. Understanding the rate-dependent cr
An optogenetic assay for the dauer decision in Caenorhabditis elegans
The palm-up open hand gesture across language modalities : A comparison of German and DGS (German Sign Language)
It is a well-established fact that the use of gestures is a ubiquitous feature of communication with language. This is true for both spoken and signed languages. However, while in spoken languages, gestures are produced in a different modality than speech (visual versus vocal/auditory, respectively), gestural elements in sign languages are produced in the same modality as sign (both are visual). T
An experimental study of jet-wall and jet-jet interactions of directly injected hydrogen and methane in a wave-piston geometry
This study investigates the interaction dynamics of directly injected (DI) hydrogen and methane jets with wall and neighboring jets in a non-reactive environment, focusing on the influence of wave-shaped piston geometry. Experiments were conducted in a high-pressure optical chamber using a custom 2-hole DI injector, with Schlieren imaging employed to capture the temporal evolution of jet structure
