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Design of recombinant antibody microarrays for serum protein profiling: Targeting of complement proteins

Antibody-based microarrays is a novel technology with great promise for high-throughput proteomics. The process of designing high-performing arrays has, however, turned out to be challenging. Here, we have designed the next generation of a human recombinant scFv antibody microarray platform for protein expression profiling of nonfractionated biotinylated human plasma and serum proteomes. The setup

Outflow facility in the monkey eye: effects of calcitonin gene-related peptide, cholecystokinin, galanin, substance P and capsaicin

A study in cats has shown that intracameral injection of calcitonin gene-related peptide (CGRP) increases the outflow facility by four- to fivefold concomitant with a decrease in intra-ocular pressure (IOP). Since there are great differences in the anatomy of the aqueous outflow routes between cats and primates, we have examined the effects of CGRP in the cynomolgus monkey. The possible influence

Subgroup Analyses in Randomized Controlled Trials: The Need for Risk Stratification in Kidney Transplantation

Although randomized controlled trials (RCT) are the gold standard for establishing causation in clinical research, their aggregated results can be misleading when applied to individual patients. A treatment may be beneficial in some patients, but its harms may outweigh benefits in others. While conventional one-variable-at-a-time subgroup analyses have well-known limitations, multivariable risk-ba

Newborn human brain identifies repeated auditory feature conjunctions of low sequential probability

Natural environments are usually composed of multiple sources for sounds. The sounds might physically differ from one another only as feature conjunctions, and several of them might occur repeatedly in the short term. Nevertheless, the detection of rare sounds requires the identification of the repeated ones. Adults have some limited ability to effortlessly identify repeated sounds in such acousti

Neuropathology of white matter lesions in vascular cognitive impairment.

The white matter is an important locus for tissue damage in vascular cognitive impairment and white matter lesions often dominate over gray matter changes. The spectrum of ischemic white matter lesions histopathologically represents focal and diffuse lesions, the most common form being the combination of both, in varying proportions. In the combined pathology, the diffuse lesion represents a gradi

Seed set differs in relation to pollen and nectar foraging flower visitors in an insect-pollinated herb

Assessing the relative contributions to seed sets of each of a plant species' floral visitors provides an indication of the relative influence of these visitors on the plants' reproductive success. In this study we compared the seed set of the gynodioecious Knautia arvensis (Dipsacaceae) in 49 local plant populations in two regions of southern Sweden. We measured the seed set for hermaphroditic an

The middle Cambrian cosmopolitan key species Lejopyge laevigata and its biozone: new data from Sweden

The middle Cambrian Lejopyge laevigata Zone is poorly exposed in Scandinavia. Both this zone, however, and the succeeding Agnostus pisiformis Zone are well exposed at a classic locality at Gudhem, Vastergotland, south-central Sweden. The sequences consist of finely laminated alum shale with scattered stinkstone (orsten) lenses. Three measured and sampled sections yielded a diverse fossil fauna, do

Dispersion in Ice-Covered Lakes

Dispersion studies in three ice-covered lakes are presented. One of the lakes has a large river through-flow. In the other two lakes, small seiche-induced currents are generated through wind action on the ice cover. Dispersion coefficients are computed from five dye experiments lasting from ½ day to 16 days. These coefficients are related to measured current velocities. The turbulence in the river

Poly(3-hydroxybutyrate) biosynthesis in the biofilm of Alcaligenes eutrophus, using glucose enzymatically released from pulp fiber sludge

Glucose, enzymatically released from pulp fiber sludge, was combined with inorganic salts and used as a growth medium for Alcaligenes eutrophus, a gram-negative strain producing poly (3-hydroxybutyrate) (PHB). By controlling the concentrations of the inorganic salts in the growth medium, almost 78% of the cell mass was converted to pure PHB. Efforts were made to find conditions for bacterial growt

Conservation of seed-dispersing migrant birds in Mediterranean habitats: Shedding light on patterns to preserve processes

Migratory frugivorous birds disperse the seeds of many plant species, forming mutualistic associations that render frugivores a priority for conservation in many habitats worldwide. We analysed the distribution of seed-dispersing frugivorous passerines in southern Spain, which is an important area for the conservation of European birds during winter. Frugivorous birds showed similar regional abund

Means for STI prevention--how are they applied and how effective are they?

The present communication concerns factors, the application of which may contribute to reduce the transfer rate of sexually transmitted infections (STIs), including geomedical aspects. The factors elaborated on are, e.g. maternal health care, sexual education early in life, health prevention programmes and sexual risk reduction counselling of commercial sex workers, screening activities as well as

Holocene changes in atmospheric circulation recorded in the oxygen-isotope stratigraphy of lacustrine carbonates from northern Sweden

The oxygen-isotope composition of local precipitation (delta(18)O(P)) is reconstructed from carbonate lake-sediment components in a sediment core covering the last 10000 calendar years from Lake Tibetanus, a small, hydrologically open, groundwater-fed take in the Abisko area, northern Sweden. Comparison of the delta(18)O(P) history with a pollen-based palaeotemperature record from the same core cl

Pharmacokinetics of doxorubicin in children with acute lymphoblastic leukemia: Multi-institutional collaborative study

Background, In adults, it has been shown that the pharmacokinetics of doxorubicin are highly variable, despite standardization of the dose based on body surface area (BSA). The purpose of this study was to determine the plasma concentrations of doxorubicin and its active metabolite doxorubicinol in children treated for acute lymphoblastic leukemia (ALL). Procedure. Children, 107 in number, aged 1.

Transcriptional profiling and assessment of cell lines as in vitro models for mantle cell lymphoma

Mantle cell lymphoma (MCL) is an aggressive malignancy and new treatment modalities must be established to increase patient survival time. In the search for new therapeutic targets, reliable and well-characterised in vitro models are essential. In this study, we have characterised three MCL cell lines (SP53, Granta 519 and NCEB1) in comparison with primary tumors front MCL, follicular lymphomas (F

Geriatric rehabilitation as an integral part of geriatric medicine in the Nordic countries

Objectives: First, to outline the theoretical and practical framework for geriatric rehabilitation in the Nordic countries and second, to survey the scientific medical publications for evidence-based geriatric rehabilitation. Methods: Brainstorming on geriatric rehabilitation in a working group of Nordic teachers in geriatric medicine. Papers on scientific programmes for geriatric rehabilitation f

Antimuscarinic drugs in detrusor overactivity and the overactive bladder syndrome: motor or sensory actions?

Antimuscarinic drugs are generally thought to exert their therapeutic action on detrusor overactivity by reducing the ability of the detrusor muscle to contract. We review currently available published data to establish whether there is any evidence to support this contention. Using a PubMed data search, only 14 original articles (including two abstracts) were found that contained cystometric data

Changes in calcium metabolic indices during long-term treatment of patients with essential hypertension

1. Disturbances of calcium metabolism, mimicking mild, compensated secondary hyperparathyroidism, accompany essential hypertension, but it is not known whether these alterations are primary or only secondary to the elevated blood pressure. 2. Indices of systemic calcium metabolism were followed prospectively during 6 months' treatment with either propranolol, bendroflumethiazide or verapamil in 35