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Crosstalk Between GABAergic Neurotransmission and Inflammatory Cascades in the Post-ischemic Brain : Relevance for Stroke Recovery
Adaptive plasticity processes are required involving neurons as well as non-neuronal cells to recover lost brain functions after an ischemic stroke. Recent studies show that gamma-Aminobutyric acid (GABA) has profound effects on glial and immune cell functions in addition to its inhibitory actions on neuronal circuits in the post-ischemic brain. Here, we provide an overview of how GABAergic neurot
Do Firm Support Increase Investments? Evidence from the Aquaculture and Fish Processing Sectors in Sweden
The European Union provides firm support to the maritime sector to reach the policy objectives in the Common Fisheries Policy. This paper analyzes to what extent the investment support to aquaculture and fish processing firms in Sweden increases firm investment activity. By doing so, the paper also quantifies the amount of investments that would have been undertaken also without support (deadweigh
Changes in P2Y6 receptor-mediated vasoreactivity following focal and global ischemia
Ischemia, both in the form of focal thromboembolic stroke and following subarachnoid hemorrhage (SAH), causes upregulation of vasoconstrictive receptor systems within the cerebral vasculature. Descriptions regarding changes in purinergic signaling following ischemia are lacking, especially when the importance of purinergic signaling in regulating vascular tone is taken into consideration. This pro
Exploring Factors Promoting Recycling Behavior in Student Housing
As climate-related issues are important and concern all aspects of the built environment, there is a need to better understand the motives underlying household recycling behavior. The purpose of the present study is twofold: to investigate factors important for explaining the recycling behavior of young people and to explore respondents’ own ideas regarding barriers to recycling. This paper report
Transcalar design : an approach to biodesign in the built environment
Biodesign holds the potential for radically increasing the sustainability of the built environment and our material culture but comes with new challenges. One of these is the bridging of the vast differences of scale between microbiological processes and architecture. We propose that a transcalar design approach, which weaves together nonlinear dependencies using computational design tools and des
An experimental and theoretical study of the Kr 3d correlation satellites
The Kr 3d correlation satellites have been studied experimentally by using plane polarized synchrotron radiation to record polarization dependent photoelectron spectra (PES), and theoretically by employing the R-matrix method to calculate photoionization cross sections, PES and angular distributions. The experimental spectra have allowed the photoelectron anisotropy parameters characterizing the a
Seasonal variation of vasopressin and its relevance for the winter peak of cardiometabolic disease : A pooled analysis of five cohorts
Background: Vasopressin concentration is typically higher at night, during stress, and in males, but readily lowered by water intake. Vasopressin is also a causal candidate for cardiometabolic disease, which shows seasonal variation. Objective: To study whether vasopressin concentration varies by season in a temperate climate. Methods: The vasopressin surrogate marker copeptin was analyzed in fast
Lifestyle Factors and Disease Activity Over Time in Early Axial Spondyloarthritis : The SPondyloArthritis Caught Early (SPACE) Cohort
Objective. Our aim was to study the importance of baseline BMI, smoking, and alcohol consumption (AC) for disease activity (DA) over 1 year in early axial spondyloarthritis (axSpA), stratified by sex. Methods. In the SPondyloArthritis Caught Early cohort (patients with chronic back pain onset at age < 45 yrs, with pain for ≥ 3 months and ≤ 2 yrs), the Ankylosing Spondylitis Disease Activity Score
Sound Reduction of Ventilation Ducts through Walls : Experimental Results and Updated Models
Ventilation ducts can have a negative effect on the sound reduction index between two rooms if they pass through the dividing structure without treatments. The overall sound reduction of a ventilation duct is dependent on several factors including the transmission loss when sound is breaking in and out from the duct. This study aims to model the sound reduction of a combined system with a separati
Atomic Structure and Valence State of Cobalt Nanocrystals on Carbon under Syngas Versus Hydrogen Reduction
The composition of the reducing gas in the activation of Co Fischer-Tropsch synthesis catalysts determines the nature of the catalytically active Co species. This study reports on the effect of H2versus syngas (H2/CO = 2) on the reducibility of Co3O4nanoparticles supported on hollow carbon spheres, using ex situ and in situ high-resolution aberration-corrected analytical electron microscopy. High-
Den mångtydiga ortodoxin En kritisk granskning av den moderna forskningens perspektiv på tidigkristen heresiologi
The history of Christianity is marked by frequent debates over doctrinal truth. From an early stage, Christian authors began to use the terms "orthodoxy" and "heresy" to deal with diversity of faith. While the orthodox faith was seen as the one that had been preserved from the time of the apostles, heresies were seen as later innovations. This idea was expressed in the Ecclesiastical History by Eu
Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis
Aquaporin channels facilitate bidirectional water flow in all cells and tissues. AQP4 is highly expressed in astrocytes. In the CNS, it is enriched in astrocyte endfeet, at synapses, and at the glia limitans, where it mediates water exchange across the blood-spinal cord and blood-brain barriers (BSCB/BBB), and controls cell volume, extracellular space volume, and astrocyte migration. Perivascular
Gudar och människor bland texter och paratexter : Om varför Gamla testamentet inte har några författare
It is a wellknown fact that the books of the Hebrew Bible are, to a great extent, anonymous and that the individuals long identified as their authors (Moses, Isaiah, David, Solomon, and so on) are not the ones who have penned them. How, then, should the few paratexts that do, in fact, relate texts explicitly to named individuals be understood? In this article, I argue that such a question is essen
Impact of comorbidity in older patients with peripheral T-cell lymphoma : an international retrospective analysis of 891 patients
Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of aggressive neoplasms with poor outcomes, commonly affecting older patients with comorbidities. This study aims to describe outcomes of older patients with PTCL in a large international cohort. Patients aged $70 years with PTCL diagnosed from 1 January 2010 to 31 December 2015 in the Swedish Lymphoma Registry (SLR) and California Cancer
Gene-environment interactions and metal toxicity
Humans are exposed to various metals through many different routes and each person’s genetic background contributes to their susceptibility to metal toxicity. In addition, recent evidence points to a role for the genetics of the human microbiome in metal uptake and toxicity. DNA sequence variation in genes that regulate metal toxicokinetics and toxicodynamics influences metal accumulation and rete
Structure of an Ultrathin Oxide on Pt3Sn(111) Solved by Machine Learning Enhanced Global Optimization**
Determination of the atomic structure of solid surfaces typically depends on comparison of measured properties with simulations based on hypothesized structural models. For simple structures, the models may be guessed, but for more complex structures there is a need for reliable theory-based search algorithms. So far, such methods have been limited by the combinatorial complexity and computational
The loyal defence lawyer
The work of defence lawyers entails managing emotions to ensure that they remain appropriate to the situation - whether that be a criminal trial or the law offices. This demands emotional dexterity and interactional skill, not least due to the particular role of defence lawyers who work closely with clients, view gruesome evidence and who often face moral suspicion. This chapter explores the vario
Acute echocardiographic and hemodynamic response to his-bundle pacing in patients with first-degree atrioventricular block
Background: Atrial pacing and right ventricular (RV) pacing are both associated with adverse outcomes among patients with first-degree atrioventricular block (1°AVB). His-bundle pacing (HBP) provides physiological activation of the ventricle and may be able to improve both atrioventricular (AV) and inter-ventricular synchrony in 1°AVB patients. This study evaluates the acute echocardiographic and
Microgravity crystallization of perdeuterated tryptophan synthase for neutron diffraction
Biologically active vitamin B6-derivative pyridoxal 5′-phosphate (PLP) is an essential cofactor in amino acid metabolic pathways. PLP-dependent enzymes catalyze a multitude of chemical reactions but, how reaction diversity of PLP-dependent enzymes is achieved is still not well understood. Such comprehension requires atomic-level structural studies of PLP-dependent enzymes. Neutron diffraction affo