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Glutathione (GSH) reduction of the anticancer-active platinum(IV) compounds trans-[PtCl4(NH3)(thiazole)] (1), trans-[PtCl4(cha)(NH3)] (2), cis-[PtCl4(cha)(NH3)] (3) (cha=cyclohexylamine), and cis-[PtCl4(NH3)2] (4) has been investigated at 25 °C in a 1.0 M aqueous medium at pH 2.0–5.0 (1) and 4.5–6.8 (2–4) using stopped-flow spectrophotometry. The redox reactions follow the second-order rate law d[

Ascorbate (Asc) reductions of the oral anticancer platinum(IV) prodrugs cis,trans,cis-[PtCl2(OAc)2(cha)(NH3)] (JM216) and cis,trans,cis-[PtCl2(OCOC3H7)2(cha)(NH3)] (JM221) and of the isomers of JM216, viz.trans,cis,cis-[PtCl2(OAc)2(cha)(NH3)] (JM394) and trans,trans,trans-[PtCl2(OAc)2(cha)(NH3)] (JM576) (OAc = acetate, cha = cyclohexylamine) have been investigated in a 1.0 M aqueous perchlorate me

Reduction of the anticancer trans platinum(IV) prodrug JM335 by thiols in a moderately alkaline aqueous perchlorate medium is quite rapid and yields trans-[Pt(OH)2(c-C6H11NH2)(NH3)] as the reaction product. The mechanism of reduction involves reductive attack by thiol or thiolate on one of the mutually trans chloride ligands, leading to the formation of a chloride-bridged activated complex.The red

Lexical semantics is concerned with modeling the meaning of lexicalitems. Its leading questions are how forms and meanings combine, what theymean, how they are used, and of course also how they change. The answers tothese five questions make up the fundamental theoretical assumptions and commitments which underlie different theories of lexical semantics, and they form the basis for their various m

To improve, it’s crucial to see! Vital characteristics of Lean are visualisation and transparency, i.e. allowing everyone to see all what occurs in production. A common tool for this purpose is Value Stream Mapping (VSM). Due to varying flows, performing a successful VSM in construction confers additional challenges. In this paper, lessons learned from successful VSM studies in construction are prTo improve, it’s crucial to see! Vital characteristics of Lean are visualisation and transparency, i.e. allowing everyone to see all what occurs in production. A common tool for this purpose is Value Stream Mapping (VSM). Due to varying flows, performing a successful VSM in construction confers additional challenges. In this paper, lessons learned from successful VSM studies in construction are pr

The kitchen is the heart of the house where people spend much of their time. It is, therefore, an important room that requires high quality. Because construction is argued to be unproductive and wasteful with low quality, studying a kitchen assemblage in detail is of particular interest due to its complexity with many details. In lean, the visualization and transparency of processes is the core fo

Synopsis In methanol solutions of Zeise's salt, the parent complex [PtCl3(C2H4)]- as well as its solvolysis product, trans-[PtCl2(C2H4)(MeOH)], exchange rapidly with free ethene. The olefin exchange process, which is largely entropy controlled, involves the substitution labile site trans to the coordinated ethene. Abstract Complex equilibria in methanol/chloroform/dichloromethane solutions contain

Spectroscopic studies of the reaction of [Os-3(CO)(11)MeCN)] with para-thiocresol to form [Os-3(mu-H)(CO)(10)(mu-SC6H4Me-p)] indicate that the reaction proceeds via a two-step consecutive process involving the intermediate [Os-3(CO)(11)-(MeC6H4SH-p)], in which there is an agostic Os-H-S interaction.

Complex formation between Pd(H2O)(4)(2+) and maleic acid (H(2)A) has been studied at 25 degrees C and 2.00 M ionic strength in acidic aqueous solution. Reaction takes place with 1:1 stoichiometry. The kinetics has been followed by use of stopped-flow spectrophotometry under pseudo-first-order conditions with maleic acid in excess. In the concentration ranges 0.01 less than or equal to [H(2)A](tot)

SynopsisOn the basis of kinetic studies of the manganese-catalyzed autoxidation of sulfite and thermodynamic data for iron−manganese redox processes and manganese(II) and -(III) protolysis equilibria, the catalytically active species in the autoxidation is concluded to be a mixed-valence oxo-bridged manganese(II,III) complex. Iron−manganese synergism and triggering of the chain reaction by small c