Epithelial cells have been suggested as potential drivers of lung fibrosis, although the epithelial-dependent pathways that promote fibrogenesis remain unknown. Extracellular matrix is increasingly recognized as an environment that can drive cellular responses in various pulmonary diseases. In this study, we demonstrate that transforming growth factor-β1 (TGF-β1)-stimulated mouse tracheal basal (M

Because the 14C calibration curves IntCal and SHCal are based on data from temperate latitudes, it remains unclear which curve is more suitable for archaeological and paleoenvironmental records from tropical South America. A review of climate dynamics reveals a significant influx of Northern Hemisphere air masses and moisture over a substantial part of the continent during the South American Summe

Thromboembolism frequently occurs during acute lymphoblastic leukemia (ALL) therapy. We prospectively registered thromboembolic events during the treatment of 1772 consecutive Nordic/Baltic patients with ALL aged 1 to 45 years who were treated according to the Nordic Society of Pediatric Hematology and Oncology ALL2008 protocol (July 2008-April 2017). The 2.5-year cumulative incidence of thromboem

We demonstrate that our approach [Phys. Rev. C 95, 061305(R) (2017)PRCHCD2469-998510.1103/PhysRevC.95.061305] serves as a useful tool to describe the gross structure of the spreading widths of the giant resonances of the doubly magic heavy nuclei. It reduces significantly the computational efforts implementing the ideas of random matrix distribution of the coupling between one-phonon and two-phono

Starch particles modified by esterification with dicarboxylic acids to give octenyl succinic anhydride (OSA) starch is an approved food additive that can be used to stabilize oil in water emulsions used in foods and drinks. However, the effects of the OSA modification of the starch particle on the interfacial interactions are not fully understood. Here, we directly measured the packing of films of

In modern gas turbine engines, the first stage vane endwall endures high thermal load with the increase of the turbine inlet temperature and the uniformity of the temperature distribution at combustor outlet. Moreover, the endwall secondary flow forces the coolant flow toward the suction side, resulting in hot regions along the pressure side endwall. In the worst case, hot regions lead to thermal

Inclusive jet and dijet cross-sections are measured in proton-proton collisions at a centre-of-mass energy of 13 TeV. The measurement uses a dataset with an integrated luminosity of 3.2 fb−1 recorded in 2015 with the ATLAS detector at the Large Hadron Collider. Jets are identified using the anti-kt algorithm with a radius parameter value of R = 0.4. The inclusive jet cross-sections are measured do

There is growing evidence of ongoing changes in the statistics of intra-seasonal rainfall variability over large parts of the world. Changes in annual total rainfall may arise from shifts, either singly or in a combination, of distinctive intra-seasonal characteristics -i.e. rainfall frequency, rainfall intensity, and rainfall seasonality. Understanding how various ecosystems respond to the change

Although the relationship between trade and the success of international sanctions has been a topic of many debates in political economy over the past 30 years, the effect of sanctions on foreign direct investment (FDI) is still largely unexplored. Using the data for 184 countries from 1970 to 2010 and bias-corrected estimators, this study tests the effect of sanction imposition on foreign investm

In this work, we synthesized a series of nanoparticle-supported boronic acid polymer brushes for affinity separation of glycoproteins. Polymer brushes were prepared by surface-initiated atom transfer radical polymerization of glycidyl methacrylate and N-isopropylacrylamide, followed by stepwise modification of the pendant as well as the end functional groups to introduce boronic acid moieties thro

Like many birds [1], numerous species of nocturnal moths undertake spectacular long-distance migrations at night [2]. Each spring, billions of Bogong moths (Agrotis infusa) escape hot conditions in different regions of southeast Australia by making a highly directed migration of over 1,000 km to a limited number of cool caves in the Australian Alps, historically used for aestivating over the summe

Transcription factors normally regulate gene expression through their action at sites where they bind to DNA. However, the balance of activating and repressive functions that a transcription factor can mediate is not completely understood. Here, we showed that the transcription factor PU.1 regulated gene expression in early T cell development both by recruiting partner transcription factors to its

Tropical tree crops such as cacao and coffee are produced around the tropics in diverse, multistrata agroforests as well as monoculture plantations Box 16.1 and references therein). The smallholders cultivating these systems battle pests and diseases that differ regionally and change over time, but often take a significant part of their yield, and therefore their revenue. In these perennial system

BACKGROUND: There is a lack of published, validated questionnaires for evaluating psychosocial morbidity in patients with breast hypertrophy undergoing breast reduction surgery.AIM: To validate the breast evaluation questionnaire (BEQ), originally developed for the assessment of breast augmentation patients, for the assessment of psychosocial morbidity in patients with breast hypertrophy undergoin

In recent years, it has become increasingly popular to use matrices, such as acellular dermal matrices, in implant-based breast reconstruction. To lower the cost and to avoid implanting biological material, the use of synthetic meshes has been proposed. This is the first study examining TIGR® Mesh in a larger series of immediate breast reconstruction. The aims of the study were to examine complica

Background Monotherapy with anticoagulation has been considered as first-line therapy in patients with mesenteric venous thrombosis (MVT). The aim of this study was to evaluate outcome, prognostic factors, and failure rate of anticoagulation as monotherapy, and to identify when bowel resection was needed.Methods Retrospective study of consecutive patients with MVT diagnosed between 2000 and 2015.RBACKGROUND: Monotherapy with anticoagulation has been considered as first-line therapy in patients with mesenteric venous thrombosis (MVT). The aim of this study was to evaluate outcome, prognostic factors, and failure rate of anticoagulation as monotherapy, and to identify when bowel resection was needed.METHODS: Retrospective study of consecutive patients with MVT diagnosed between 2000 and 2015

Rapid economic growth, urbanization and increasing population have caused (materially intensive) resource consumption to increase, and consequently the release of large amounts of waste to the environment. From a global perspective, current waste and resource management lacks a holistic approach covering the whole chain of product design, raw material extraction, production, consumption, recycling

Technological advances, with increasing numbers of products containing complex electronic circuitry, have resulted in e-waste becoming the fastest-growing global waste stream. High levels of embodied carbon in these products ensure that, to meet emissions reduction targets proposed by the United Nations Paris Agreement, tackling e-waste requires strategies to address climate change United Nations

Increasing global demand for durable goods prevents the decoupling of economic growth from natural resource use required to achieve sustainable consumption and production. Presently, most consumers in the United Kingdom (UK) exhibit a strong preference for purchasing new durable goods. Therefore, short-to-medium term strategies that seek to engender sustainable consumption of durable goods should