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Erythropoiesis is intimately coupled to cell division, and deletion of the cell cycle regulator retinoblastoma protein (pRb) causes anemia in mice. Erythroid-specific deletion of pRb has been found to result in inefficient erythropoiesis because of deregulated coordination of cell cycle exit and mitochondrial biogenesis. However, the pathophysiology remains to be fully described, and further chara
This review discusses magnetomotive ultrasound, which is an emerging technique that uses superparamagnetic iron oxide nanoparticles as a contrast agent. The key advantage of using nanoparticle-based contrast agents is their ability to reach extravascular targets, whereas commercial contrast agents for ultrasound comprise microbubbles confined to the blood stream. This also extends possibilities fo
Uppdaterad upplaga. Lärobok.
In this experimental study, mass transfer and hydrodynamic parameters of water/kerosene/acetic acid system in a packed column were investigated, in which the mass transfer direction was set from the continuous phase (saturated water of kerosene and acetic acid) to the dispersed phase (saturated kerosene of water) in all the experiments. To assess the impact of nanoparticles on mass transfer, the e
Uppdaterad upplaga. Lärobok. Lagkommentarer och rättsfall.
Background: A common bearing combination in total hip arthroplasty today is a metal femoral head articulating with polyethylene in the cup. Ceramic heads are thought to be more resistant to third-body damage, and have better wettability and decreased surface roughness, which taken together have been suggested to result in less polyethylene wear. The purpose of this study is to compare the initial
Investment in railways, and transport infrastructure in general, are often motivated because they are believed to improve peoples’ accessibility to jobs. By linking together and increasing the size of labour markets, the matching between individuals and jobs is improved, and the productivity increases. Communities and municipalities lobby for investments that lead to higher accessibility and those
Background: Recent reports suggest that the negative association between diabetes mellitus and abdominal aortic aneurysm (AAA) may be driven by metformin, the world's most common antidiabetic drug rather than diabetes per se. We sought to investigate the association among AAA growth rate, chemokine profile, and metformin prescription in a contemporary Swedish cohort. Methods: Patients under survei
Att vara anhörig är att få höra an till någon, att vara närstående är att få stå någon nära. Anhörigskap är för de flesta inte att vara en resurs, en funktion eller en kategori. Anhörigskap är relation, en relation till en annan människa som man vill ha i sin närhet och vara nära. Det finns ett fokus på den enskilde individen, som genomsyrar mötet mellan offentlig verksamhet och invånare. Detta gö
This article aims to enable a conversation between cosmopolitan thought, with focus on individual ethical experiences and reflections, and research on embodied military experiences. While we derive our ethical reasoning from cosmopolitanism, we concede that it lacks sensitivity to individuals’ other-regarding reflections and acts. Moreover, it does not sufficiently problematize the ways in which c
Glaucoma is a widespread sight-threatening condition often only recognized when very pronounced. It is initially characterized by peripheral visual field losses, while advanced stages also affect the central vision. Some of these patients may experience visual hallucinations, the Charles Bonnet syndrome (CBS). In this systematic review and meta-analysis, we provide an overview of the literature de
Does a teachable agent influence the uptake or neglect of ‘critical constructive feedback’ and learning within a digital environment? 285 middle-school students engaged with a history learning game in a 2x2 study design. One dimension was inclusion of a teachable agent. Orthogonal was whether critical constructive feedback was presented automatically or only when students chose. Analyses showed th
Version management is a prerequisite for digital information flow between phases in the planning and building processes. Information evolves over time and many parties retrieve information from the various phases. The aim of this article is to evaluate versioning methods, focusing on geodata buildings in the 3D cadastre process. The main attention in the evaluation is on the comprehensive ISO stan
The present work numerically studied the enhanced heat transfer mechanism of the coupled fields of detached and spiral vortices in symmetrical and asymmetrical spirally corrugated tubes. The heat transfer and viscous dissipation were analyzed by evaluating the entropy combined with the flow patterns, and the global entropy generation rate was analyzed by considering the local Nusselt number and fr
Background and purpose — Despite the good results after total hip arthroplasty (THA), new implants are continuously being developed to improve durability. The Echo Bi-Metric (EBM) THA stem is the successor to the Bi-Metric (BM) THA stem. The EBM stem includes many of the features of the BM stem, but minor changes in the design might improve the clinical performance. We compared the migration behav
We present novel coupling schemes for partitioned multiphysics simulation that combine four important aspects for strongly coupled problems: implicit coupling per time step, fast and robust acceleration of the corresponding iterative coupling, support for multirate time stepping, and higher-order convergence in time. To achieve this, we combine waveform relaxation—a known method to achieve higher-
Background: Cardiac allograft vasculopathy (CAV) is characterized by diffuse thickening of the arterial intima. Statins reduce the incidence of CAV, but despite the use of statins, CAV remains one of the leading causes of long-term death after heart transplant. Inhibitors of proprotein convertase subtilisin-kexin type 9 (PCSK9) substantially reduce cholesterol levels but have not been tested in he
Purpose: This paper aims to unveil how sustainability is integrated into the courses/programmes of higher education institutions. The research question addressed is: how do academics representing different disciplines cooperate and engage in the work of integrating sustainability into their teaching programmes. Design/methodology/approach: This paper draws upon the notions of practise variation an
