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Diamond-Blackfan anemia is a rare genetic bone marrow failure disorder which is usually caused by mutations in ribosomal protein genes. In the present study, we generated a traceable RPS19-deficient cell model using CRISPR-Cas9 and homology-directed repair to investigate the therapeutic effects of a clinically applicable lentiviral vector at single-cell resolution. We developed a gentle nanostraw
Leukemia cutis or leukemic cell infiltration in skin is one of the common extramedullary manifestations of acute myeloid leukemia (AML) and signifies a poorer prognosis. However, its pathogenesis and maintenance remain understudied. Here, we report massive AML cell infiltration in the skin in a transplantation-induced MLL-AF9 AML mouse model. These AML cells could regenerate AML after transplantat
Agricultural nanotechnology has become a powerful tool to help crops and improve agricultural production in the context of a growing world population. However, its application can have some problems with the development of harvests, especially during germination. This review evaluates nanoparticles with essential (Cu, Fe, Ni and Zn) and non-essential (Ag and Ti) elements on plant germination. In g
The end-Triassic mass extinction (ETE; ~201.6 million years ago) led to dramatic changes in terrestrial ecosystems including the extinction of several seed-plant groups. Among the most intriguing features in the vegetation signal is the dominance of the peculiar pollen, Ricciisporites tuberculatus Lundblad, across large areas of the Northern Hemisphere immediately prior to and during the ETE. The
Bronchial asthma is a heterogeneous respiratory condition characterized by chronic airway inflammation, airway hyperresponsiveness and airway structural changes (known as remodeling). The clinical symptoms can be evoked by (non)specific triggers, and their intensity varies over time. In the past, treatment was mainly focusing on symptoms’ alleviation; in contrast modern treatment strategies target
A model that simulates surface moisture content on sandy beaches for aeolian transport applications is developed and integrated into the aeolian transport model AeoLiS. The moisture content of a thin surface layer (≈2 mm thickness) is computed as a function of wave runup, precipitation, evaporation, percolation, and capillary rise from the groundwater table. The groundwater table is simulated usin
Languages vary considerably in how they group objects into categories. For example, the word taza in Spanish can refer to either cup or mug in English, whereas glass can refer to either copa or vaso – two different types of glasses –, in Spanish. It is still debated whether such language distinctions cause differences in early perceptual processing between speakers of different languages. Here, fo
Background: We aimed to evaluate cumulative occurrence and impact of COVID-19 in patients with chronic respiratory failure (CRF) treated with long-term oxygen therapy (LTOT). Material and methods: Data were obtained from the SCIFI-PEARL study on the entire Swedish population and on patients with oxygen-dependent CRF and no COVID-19 diagnosis before start of LTOT. Analyses were performed for three
Wide variation in visual field configuration across avian species is hypothesized to be driven primarily by foraging ecology and predator detection. While some studies of selected taxa have identified relationships between foraging ecology and binocular field characteristics in particular species, few have accounted for the relevance of shared ancestry. We conducted a large-scale, comparative anal
Debates around age effects in L2 learning have mostly centred around the domains of phonology, morphosyntax, and lexis. In this chapter, we expand the scope to conceptual and cognitive restructuring, much in line with Long’s (1990, 2013) discussion of the limits of age effects. Drawing on an extensive review of the extant literature, the current chapter examines the role that age of L2 acquisition
This chapter discusses Ilia Repin’s court commission, Reception of Volost Elders by Alexander III in the Courtyard of the Petrovsky Palace in Moscow (1886). It argues that the painting reflected marginalizing discourses on the non-Russian minorities dominant at the outset of Alexander III’s rule. Repin employed a differentiating approach to rendering ethnically and religiously diverse representati
The article investigates the ways in which Pirjo Honkasalo’s documentary The 3 Rooms of Melancholia (2004), examining the impact of the Russian-Chechen war on children, engenders a transnational audience through cinematic qualities, and most importantly through embodiment, producing a strongly affective resonance in the spectator. I argue that through a strategically affective approach to transnat
Hur nådde fossildriven teknik Egypten på sin väg mot global dominans? Denna avhandling presenterar en socioekologisk historia av energiteknologier i förkoloniala Egyptens jordbruksproduktion (1820-talet-76). Den placerar dem i 1800-talet, början på Kapitalocenens epok; och i Egyptens fall är detta samtidigt en del av Storbritanniens fossila imperiums uppkomst. Denna avhandling behandlar hur ångmasHow did fossil-fuelled technology find its way to Egypt on its way to global dominance? This thesis presents a socioecological history of energy technologies in agrarian production in pre-colonial Egypt (1820s – 76). It situates them in the nineteenth century, understood as the beginning of the epoch of the Capitalocene; and in Egypt’s case, this is simultaneously part of the rise of Britain’s fos
Polarized neutron imaging brings the great advantage of analyzing bulk magnetic properties with good spatial resolution. The technique is based on the interaction of the neutron spin with magnetic samples or free magnetic fields and observing the changes to a spin-polarized neutron beam. The high sensitivity to even small magnetic fields is a benefit in obtaining magnetization information but simu
Acute myeloid leukemia (AML) is initiated and propagated by leukemia stem cells (LSCs), a self-renewing population of leukemia cells responsible for therapy resistance. Hence, there is an urgent need to identify new therapeutic opportunities targeting LSCs. Here, we performed an in vivo CRISPR knockout screen to identify potential therapeutic targets by interrogating cell surface dependencies of L
This edited collection proposes instituting as a potentially critical methodology in curating, art making and social organizing today, and seeks to discuss forms and structures that take place inside and outside institutions. Rethinking of collective artistic and social practices through and beyond the “waves of institutional critique” this books discusses instituting as a process in continuous cr
Indirect excitons are the focus of intense research due to the opportunity of studying degenerate quantum gases and liquids in an excitonic system. To realize such systems, it is highly advantageous to have as little scattering as possible. A polytype type-II interface is formed between wurtzite and zincblende InP due to the band alignment. Electrons gather on the zincblende and holes on the wurtz
