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The maximum drawdown of a stochastic process is the largest peak-to-troughdecline observed over a given horizon [0, T]. Using arguments from extremevalue theory, we derive the limiting distribution of the maximum drawdown fora Brownian motion with positive drift as T → ∞. We show that, after suitablecentering and scaling, the maximum drawdown converges in distribution to theGumbel law.
BakgrundPrimärvården utgör den första linjen av vård och stöd för personer med psykisk ohälsa. Verksamheten är i huvudsak inriktad på diagnostik, medicinsk behandling och symtomlindring. Tillgången till denna vård upplevs emellertid som utmanande både av patienter och vårdgivare. En fördjupad förståelse av den levda erfarenheten av mötet med primärvården kan bidra till utvecklingen av mer individaBackground: Primary health care is in the unique position of being a first level of support and care to individuals with mental health problems. The focus in this service is on diagnosis, medical treatment, and symptom reduction. However, to access it is perceived as challenging by both patients and providers. An increased understanding of the lived experience of encountering primary health care m
Phage collections are essential tools for discovering and dissecting bacterial anti-phage defense systems. Here, we report the isolation, characterization, and annotated genome sequences of five environmental Escherichia coli-infecting phages, obtained during the 2023 Fundamentals of Basic and Applied Phage Biology course at Lund University. The phages were isolated using a motile E. coli K-12 BW2
Dementia is a decline in cognitive function that impairs a person’s previous level of social and occupational function. Dementia is a very common medical condition that can result from diverse causes. Dementias are classified based on common clinical, genetic, and neuropathological features. The most common cause of dementia is Alzheimer’s disease. Other major classes of disorders that cause demen
BackgroundAmyloid-β peptides (Aβ) applied to Alzheimer's disease (AD) brain bind to amyloid plaques (APs) and this binding is saturable. Meanwhile, anti-immunoglobulin G (IgG) antibodies label APs. Considering the saturable binding of Aβ to APs and the localization of IgGs in APs, specific binding proteins (BPs) for the applied Aβ could be anti-Aβ IgG antibodies (anti-AβAbs) in APs.ObjectiveOur ob
Background: In 2015, a proton therapy (PT) facility was established in Sweden with one aim being to ensure access for all children expected to benefit from PT. Despite potential dosimetric advantages and full subsidisation, PT is not always selected. This study explores reasons for choosing alternative radiotherapy (RT) modalities in a paediatric population. Material and methods: RT courses delive
OBJECTIVE: To synthesise evidence related to the dissemination and implementation (D&I) of injury prevention interventions for female, woman and/or girl (female/woman/girl) athletes.DESIGN: Scoping review.DATA SOURCES: MEDLINE, APA PsycInfo, Cochrane Databases for Systematic Review, Cochrane Central Register for Controlled Trials Registry, EMBASE, CINAHL, SPORTDiscus, ERIC, ProQuest Dissertati
Background: Allergic contact dermatitis (ACD) caused by isothiazolinones is a growing concern, particularly in consumer products. Octylisothiazolinone (OIT) is a potent sensitiser and commonly used as a preservative in rubbers, plastics and coatings, including those found in headphones. Despite increasing regulations on isothiazolinones in cosmetics, their presence in wearable devices remains unde
A multi-variable adaptive controller is derived as the explicit solution to a minimax dynamic game. The minimizing player selects the control action as a function of past state measurements and inputs. The maximizing player selects disturbances and model parameters for the underlying linear time-invariant dynamics. This leads to a Bellman equation that can be solved explicitly for the case with un
This brief anthology begins with a basic outline of the interdisciplinary course Smart City Governance – AI Ethics in a Spatial Context, given at LTH, Lund University. Three selected student essays from the class of 2024/2025 then follow. These demonstrate the topics possible to analyse when combining engineering students from programmes on data, ICT, architecture, and land surveying with students
The problem of approximate joint eigen-decomposition of a collection of matrices arises in a number of diverse engineering and signal processing problems. This problem is usually cast as an optimization problem, and it is the main goal of this publication to provide a theoretical study of the corresponding objective-functional. As our main result, we prove that this functional tends to infinity in
With the publication of Fossil Capital in 2016, Andreas Malm reshaped how scholars understand the relationship between capitalism and fossil fuels. Energy humanities scholars Caleb Wellum and Imre Szeman interviewed Malm in November 2024 about the arguments and impact of Fossil Capital, the development of his thought in several subsequent books, and the shifting landscape of climate politics. At a
The discourse on Business and Human Rights (BHR) has evolved substantially over the past two decades, particularly since the adoption of the UN Guiding Principles on Business and Human Rights (UNGPs) in 2011. While the UNGPs established the corporate responsibility to respect human rights through Human Rights Due Diligence (HRDD), their voluntary nature has resulted in fragmented implementation an
I den pågående kampen mot klimathotet har Europeiska unionen antagit en ledande roll för att fullfölja skiftet mot en grön ekonomi, bland annat genom att fokusera på att stärka konkurrenskraften avseende tillverkningen av netto-noll energiindustrin och säkra de nödvändiga råvarorna för denna omställning. För att möjliggöra detta presenterade den Europeiska kommissionen i mars 2023, i samband med pIn the global race against climate change, the answer of the European Union is the transition towards a green economy by focusing on strengthening the competitiveness of the net-zero technology industry and securing the necessary critical materials. To do so, the Union presented two legislative acts in the European Green Deal Industrial Plan in 2023, amongst which the Net-Zero Industry Act. While
Dopamine and serotonin are two major monoamine neurotransmitters associated with Parkinson's disease (PD), but their spatial distribution and relationship to underlying functional brain architecture are not fully understood. We assessed 30 patients with PD at baseline using structural MRI, resting-state functional MRI (rs-fMRI), 11C-PE2I and 11C-DASB PET, along with comprehensive clinical evaluati
This study explores how higher music education institutions position themselves in relation to wider social and political forces and the expanding professional responsibilities of musicians in increasingly complex Nordic societies, which in this study includes Finland, Sweden, Norway and Denmark. By asking how the political—including various local and global social-ecological values, relations and
Background: Although there is substantial evidence of the negative impact of caffeine use on sleep quality, few studies focus specifically on adolescents’ patterns of use. This study aimed to identify patterns of caffeine use among adolescents and analyze their association with sleep quality. Method: A cross-sectional study was conducted in southern Sweden including 1,404 adolescents aged 15–17 (5
We introduce Thalassa, a framework designed to convert nonlinear systems of partial differential equations (PDEs) with a time-like component into tensor programs that solve these equations. These programs can run on GPUs as well as machine learning (ML) acceleration hardware, enabling scientific computing fields such as computational fluid dynamics, astrophysics, mechanics and biology to utilize a
