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The calcium channel subunit gamma-4 is regulated by MafA and necessary for pancreatic beta-cell specification

Voltage-gated Ca2+ (CaV) channels trigger glucose-induced insulin secretion in pancreatic beta-cell and their dysfunction increases diabetes risk. These heteromeric complexes include the main subunit alpha1, and the accessory ones, including subunit gamma that remains unexplored. Here, we demonstrate that CaV gamma subunit 4 (CaVγ4) is downregulated in islets from human donors with diabetes, diabe

Removal of metals from contaminated waters : Evaluating the use of synthetic adsorbents and green algae biomass

Metal contamination of water bodies has attracted global attention owing to its environmental toxicity, abundance and persistence. Metals such as arsenic, cadmium and mercury are of greater concern since they are toxic even at low concentrations. Mercury is present at 1000 times lower concentrations than the other two metals, but still has a negative impact on the environment due to its high trans

Adsorption of cadmium by a high-capacity adsorbent composed of silicate-titanate nanotubes embedded in hydrogel chitosan beads

In this study, we developed a nanoparticle-based mesoporous composite that consisted of silicate-titanate nanotubes (STNTs) supported in hydrogel chitosan beads (STNTs-Ch beads) and was studied for Cd2+ adsorption. By using Fourier-transform infrared spectroscopy, transmission and scanning electron microscopy coupled to an energy-dispersive X-ray spectrometer, we coulddetermine that the hollow STN

Depressivity and mortality risk in a cohort of elderly men. A role of cognitive and vascular ill-health, and social participation

Objectives: Depressive symptoms in the elderly have been shown to be associated with increased mortality. The purpose of this study was to examine symptoms of depression in octogenarian men and their association with all-cause mortality, and whether physical, cognitive and social factors influence this association. Methods: Out of the 703 initially included 55-years-old men, from the prospective c

How In-Service Experience Informs Design Modifications: A Case Study in Aero Engines

This research is triggered by a fundamental shift that is occurring in the manufacture and marketing of aero engines for commercial and defence purposes, away from the selling of products to the provision of services. Under the emerging ‘power by the hour’ paradigm, aero engines are effectively leased to the airlines, with the manufacturing company remaining responsible for their maintenance and r

Rapidity density distributions in 16O, 28Si, 32S, 197Au, and 208Pb induced heavy-ion interactions at 4A–200A GeV

The mass, energy, and centrality dependence of rapidity density distributions of relativistic, charged particles, produced in heavy-ion interactions in the energy range 4A–200A GeV, are investigated. The results indicate that the rapidity density distributions show systematic variations, which are used to predict distributions for Au+Au and Pb+Pb interactions in a model-independent way.