BACKGROUND AND OBJECTIVES: Injured pericytes in the neurovascular unit release platelet-derived growth factor β (PDGFRβ) into the cerebrospinal fluid (CSF). However, it is not clear how pericyte injury contributes to Alzheimer's disease (AD)-related changes and blood brain barrier (BBB) damage. We aimed to test if CSF PDGFRβ was associated with different AD- and age-associated pathological changes

This book addresses an under-researched area within populism studies: the discourse of supporters of populist parties. Taking the 2019 European elections as their case study, the authors analyse how supporters in eleven different countries construct identities and voting motivations on social media. The individual chapters comprise a range of methods to investigate data from different social mediaThis book addresses an under-researched area within populism studies: the discourse of supporters of populist parties. Taking the 2019 European elections as their case study, the authors analyse how supporters in eleven different countries construct identities and voting motivations on social media. The individual chapters comprise a range of methods to investigate data from different social media

Studies have indicated that transportation noise is associated with higher cardiovascular mortality, whereas evidence of noise as a risk factor for respiratory and cancer mortality is scarce and inconclusive. Also, knowledge on effects of low-level noise on mortality is very limited. We aimed to investigate associations between road and railway noise and natural-cause and cause-specific mortality

Extending the concept of weakly Kannan maps on metric spaces, we study the maps as $f:X\rightarrow X$ on a metric space $(X, d)$ satisfying condition $d(f(x), f(y)) \leq (1/2)\beta(d(x, y))[d(x ,f(x)) + d(y, f(y))]$ for every $x, y\in X$ and a function $\beta: [0, \infty)\rightarrow [0,1)$ where for every sequence $t=\{t_n\}$ of non-negative real numbers satisfying $\beta(t_n)\rightarrow 1,$ while

BACKGROUND: Chronic low-grade inflammation may play a role in the pathophysiology of depression, at least in a subset of patients. High-sensitivity C-reactive protein (hs-CRP) has been used to define an inflamed subgroup of depression with specific clinical characteristics and symptoms. In this study we investigated biochemical and clinical characteristics in patients with difficult-to-treat depre

WW domain binding protein 1-like (WBP1L), also known as outcome predictor of acute leukaemia 1 (OPAL1), is a transmembrane adaptor protein, expression of which correlates with ETV6-RUNX1 (t(12;21)(p13;q22)) translocation and favourable prognosis in childhood leukaemia. It has a broad expression pattern in haematopoietic and in non-haematopoietic cells. However, its physiological function has been

The preparation of a polymer carrier for a boron delivery agent is presented through a combination of experimental and computational studies. A dodecahydro-closo-dodecaborate (B12H12)2– (B12) anion was used as a model boron-containing agent due to its high boron content. Quaternized poly(2-vinyl pyridine)-b-poly(ethylene oxide) (QP2VP-b-PEO) was chosen as a model neutral–cationic block copolymer t

Kan Bogong fjärilar dofta sig till en säker plats? Att komma hem från en lång semester och lägger sig i sin egen säng, känna doften av ens egna kudde och lägenhet ger en känsla av säkerhet. Det är en doft av hemma, av trygghet som vi känner igen. Är det möjligt att få samma upplevelse med en doft man aldrig känt förut? Så kan det vara för Bogong fjärilen (Agrotis infusa). De är nattaktiva fjärilaThe Bogong moth Agrotis infusa is a long-distance nocturnal migrant whose navigational ability still remains only partly understood. They travel up to a thousand kilometres to the Australian Alps where they seek out the shelter of isolated cool alpine caves, thereby escaping the approaching summer heat of their breeding grounds. Once in the caves, they enter a state of dormancy over the coming sum

Cardiovascular diseases are the leading cause of death worldwide, increasing yearly. However, many abnormalities in heart cycles can be discovered and treated years before the onset of diseases. But in most societies, regular health checkups are a concept reserved for cars, not humans. In order to save lives, our healthcare systems must adopt a preventative rather than a reactive approach. To that

Invasive alien species threaten biodiversity with domestic gardens acting as a major pathway for the introduction of alien species. Even though the Nordic region is not currently a hotspot for biological invasions, the number of invasions in the Nordic area has been predicted to increase due to climate change. Given a time lag between introduction and invasion, many non-invasive horticultural alie

We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacylglycerol species, and lowered sphingomyelin 42:2;2 levels are predictive of faster progression towards insulin requirement. Of ~1,300 proteins examined in two

Purpose: Tru-cut biopsy is a minimally invasive technique used to obtain tissue samples for the diagnosis of tumors, especially in patients where primary surgery is not indicated. The aim of this study was to assess the adequacy, accuracy and safety of the tru-cut biopsy for diagnosis in gynecological cancer.Methods: A retrospective population-based review of 328 biopsies was conducted. The indica

Frost formation in heat exchangers is an often accruing issue in cold climates. The aim of the project is to calculate the risk of frost formation in different Swedish cities by modeling vapor and frost behavior in heat exchangers.