Objective To explore genetic and lifestyle risk factors of MRI-defined brain infarcts (BI) in large population-based cohorts. Methods We performed meta-analyses of genome-wide association studies (GWAS) and examined associations of vascular risk factors and their genetic risk scores (GRS) with MRI-defined BI and a subset of BI, namely, small subcortical BI (SSBI), in 18 population-based cohorts (n

With the overall aim of furthering the theo¬retical and empirical investigation of professional discretion, this article builds on a combination of a conceptual framework for understanding discretion and an advanced method for collecting data on human judgments. Discretion is described as consisting of two analytically separate cate¬gories or dimensions – a structural dimension (discretionary spac

Judgement and decision-making are central activities in all professions. No matter which profession a practitioner belongs to, or which clients a practitioner is working with, he or she is regularly trying to find answers to the questions “what is the case?” and “what ought to be done?” When professionals are trying to find justifiable answers to such questions, they are reasoning. In this article

The “governing images” associated with the use and misuse of alcohol and drugs have varied across time and space. In Sweden, the 20th century saw a number of such perspectives – including the moral, the medical and the social – alternately dominating or coexisting. This multitude in perspectives is reflected in the organisation of addiction care and treatment, in which the responsibility for defin

Objective: In non-muscle-invasive bladder cancer (NMIBC), local recurrence after transurethral resection of the bladder (TURB) is common. Outcomes vary between urological centres, partly due to the sub-optimal surgical technique and insufficient application of measures recommended in the guidelines. This study evaluated early recurrence rates after primary TURB for NMIBC before and after introduci

The home has a self-evident place within audience studies. In spite of this salient position, the home has seldom been theoretically problematized; it has often been ‘reduced’ to a social context of the prioritized media engagement (domestication research is partly an exception). The paper is further justified by the fact that media and media practices are important for the home and its boundaries

The stress driven growth of an expanding precipitate at a crack tip is studied. The material is assumed to be linearly elastic, and the expansion is considered to be isotropic or transversely isotropic. The extent of the precipitate is expected to be small as compared with the crack length and distance to boundaries. The problem has only a single length scale given by the squared ratio of the stre

Worldwide, but subject to substantial variations across countries, housing adaptations and home modifications constitute important and common interventions in occupational therapy practice. Starting out from the notion that occupational performance is the outcome of person–environment–occupation (P–E–O) transactions, such interventions are applicable with all kinds of clients with occupational per

Supernormal clutches are found across bird species. Such clutches often result from more than one female laying eggs in the same nest and can reflect different behaviours from parasitism to laying mistakes. Enlarged clutches are readily visible among waders due to a maximum maternal clutch size of four eggs, yet surprisingly little is known about this phenomenon. Since supernormal clutches are rar

Introduction: In sports physiotherapy, medicine and orthopaedic randomised controlled trials (RCT), the investigators (and readers) focus on the difference between groups in change scores from baseline to follow-up. Mean score changes are difficult to interpret (is an improvement of 20 units good?'), and follow-up scores may be more meaningful. We investigated how applying three different respond