Malignant brain tumors present a major therapeutic challenge because no selective or efficient treatment is available. Here, we demonstrate that intratumoral administration of human α-lactalbumin made lethal to tumor cells (HAMLET) prolongs survival in a human glioblastoma (GBM) xenograft model, by selective induction of tumor cell apoptosis. HAMLET is a protein-lipid complex that is formed from α

We use a microscopic Slater-Koster tight-binding model with short-range exchange and atomic spin-orbit interactions that realistically captures generic features of ferromagnetic metal nanoparticles to address the mesoscopic physics of magnetocrystalline anisotropy and hysteresis in nanoparticle-quasiparticle excitation spectra. Our analysis is based on qualitative arguments supported by self-consi

Background: Secondary central nervous system (CNS) involvement by aggressive lymphoma is a well-known and dreadful clinical complication. The incidence and risk factors for CNS manifestation were studied in a large cohort of elderly (> 60 years) patients with aggressive lymphoma. Patients and methods: In all, 444 previously untreated patients were randomized to receive 3-weekly combination chemoth

Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING Omfattningen av såväl alkoholkonsumtion som psykiska besvär ho's befolkningen är av stor betydelse för folkhälsan och samhällsekonomin. Under 1990-talet har det skett förändringar av svenskarna's alkoholkonsumtion och psykiska hälsa. Alkoholkonsumtionen har ökat kraftigt. Ökningstakten har varit större bland kvinnor än bland män och säAlcohol use and mental health of the general population is of public health concern. Few population-based studies have focused on middle-aged women. The aim of this thesis was to increase knowledge about middle-aged women’s alcohol consumption, drinking patterns, mental symptoms and use of psychotropic drugs. A separate analysis focuses on immigrant women. All women aged 50-59 (n=10,766), born b

A general method to directly obtain the DNA sequence of the variable regions of any immunoglobulin chain using a mixture of oligomer primers and the polymerase chain reaction (PCR) is described. Mixed oligonucleotide primers corresponding to the 5′ signal peptide and a conserved 3′ constant region primer were used for enzymatic amplification of each of the heavy and light chain variable regions of

The diagnosis of acute, non-traumatic diseases of the lower respiratory tract requires exact knowledge of the specific anatomy, physiology and pathology of the pediatric chest. The absolutely and relatively smaller airways, as compared with those of adults, and the undeveloped collateral ventilation result in radiological appearances that are unique in children. Viral pneumonia is predominant only

OBJECTIVE: [corrected] To investigate the relationship between hormone replacement therapy (HRT), smoking, and cancer incidence.METHODS: Baseline interviews were conducted from 1990 to 1992 in a population-based cohort of 29,508 Swedish women aged 25-65 years with no history of cancer. Cancer incidence in the cohort was assessed through December 31, 1999, with the Swedish Cancer Registry, the Popu

This thesis treats regression analysis when either the dependent or the independent variable is censored. We deal with quantile regression when the dependent variable is censored. Using the independence between the true values and the censoring limits the quantile function for the true values can be rewritten as another quantile function of the observed, censored values, where the quantile value i

In this thesis a number of computer vision problems is discussed, in particular we study the problem of view synthesis. The focus is on using complex features to determine the geometry of the scene and the cameras, in contrast to traditional point-based methods. The thesis is divided into two parts: In the fist part geometric relations between different features, corresponding in several images

The role of various material fire properties in the model of fire growth developed by Magnusson and Karlsson [l] is examined in the context of the dimensionless variables containing them. It is shown that their successful representation of their calculations by power law (one for fires which do not flashover and one for those which do) permits one to devise weighting factors for the rate of heat r