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Cellular and immunological mechanisms influence host-Adapted phenotypes in a vector-borne microparasite

Predicting pathogen emergence and spillover risk requires understanding the determinants of a pathogens host range and the traits involved in host competence. While host competence is often considered a fixed species-specific trait, it may be variable if pathogens diversify across hosts. Balancing selection can lead to maintenance of pathogen polymorphisms (multiple-niche-polymorphism; MNP). The c

Climate-driven variation in biotic interactions provides a narrow and variable window of opportunity for an insect herbivore at its ecological margin

Climate-driven geographic range shifts have been associated with transitions between dietary specialism and generalism at range margins. The mechanisms underpinning these often transient niche breadth modifications are poorly known, but utilization of novel resources likely depends on phenological synchrony between the consumer and resource. We use a climate-driven range and host shift by the butt

Determinants of serum half-lives for linear and branched perfluoroalkyl substances after long-term high exposure-A study in Ronneby, Sweden

BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are persistent substances with surfactant and repellent properties. Municipal drinking water contaminated with PFAS had been distributed for decades to one third of households in Ronneby, Sweden. The source was firefighting foam used in a nearby airfield since the mid-1980s. Clean water was provided from December 16, 2013.AIMS: The purpose was

Circulating plasma microRNAs in systemic sclerosis-associated pulmonary arterial hypertension

Objectives: SSc-associated pulmonary arterial hypertension (SSc-APAH) is a late but devastating complication of SSc. Early identification of SSc-APAH may improve survival. We examined the role of circulating miRNAs in SSc-APAH. Methods: Using quantitative RT-PCR the abundance of mature miRNAs in plasma was determined in 85 female patients with ACA-positive lcSSc. Twenty-two of the patients had SSc

Continuity and change in forest restoration : A comparison of US ecology and forestry in the 1940s and 1990s

Previous research has paid little attention to the multiple meanings of the concept of forest restoration. To gain a more comprehensive view of forest restoration, this paper compares the US forest restoration debate of the 1940s and 1990s, in the disciplines of ecology and forestry. The paper focuses on historical approaches to pasts and futures, and on “sociotechnical imaginaries” providing soci

Detection and mitigation of deception attacks on cloud-based industrial control systems

In recent years, because the cloud can provide huge advantages regarding storage and computing resources, industry has been motivated to move industrial control systems to the cloud. However, the cloud also introduces major security challenges, since moving control systems to the cloud can enable attackers to infiltrate the system and establish an attack that can lead to damages and disruptions wi

Vänstern som tror på den starkes rätt – för Ryssland

Den antiamerikanska vänstern har fått en märklig ny sängkamrat efter Rysslands invasion av Ukraina: den ”realistiska” skolan inom internationella relationer, företrädd av den amerikanske professorn John Mearsheimer. Detta trots att realismen visat sig usel som prognosverktyg och att tron på den starkes rätt över den svage är något som annars brukar leda till protester – åtminstone mot USA, skriverDen antiamerikanska vänstern har fått en märklig ny sängkamrat efter Rysslands invasion av Ukraina: den ”realistiska” skolan inom internationella relationer, företrädd av den amerikanske professorn John Mearsheimer. Detta trots att realismen visat sig usel som prognosverktyg och att tron på den starkes rätt över den svage är något som annars brukar leda till protester – åtminstone mot USA, skriver

Symptoms, problems and quality of life in patients newly diagnosed with oesophageal and gastric cancer - a comparative study of treatment strategy

BACKGROUND: Patients with oesophageal and gastric cancer have a low likelihood of being cured and suffer from a broad spectrum of symptoms and problems that negatively affect their quality-of-life (QOL). Although the majority (67-75%) of patients at the time of diagnosis suffer from an incurable disease, research has primarily focused on the pre- and postoperative phase among patients treated with

The Meridian S01E03 : Exoplanetary atmospheres on World Space Week

In this third episode of the podcast Nic and Rebecca invite Jens Hoeijmakers to the mic and chat to him about ultra-hot Jupiters and their atmospheres. Thereafter they take a closer look at a comet, which is named after the its two discoverers: Michel Giacobini and Ernst Zinner.

1066 : Slaget vid Hastings

Boken är en analys av den normandiska erövringen av England, med fokus på slaget vid Hastings, men med utförliga redogörelser för tiden före och efter drabbningen.

Världens sju underverk

Boken är en översiktlig genomgång och analys av den antika världens sju underverk, med utblick mot liknande fenomen i modern tid.

RIFM fragrance ingredient safety assessment, octyl isobutyrate, CAS Registry Number 109-15-9

The existing information supports the use of this material as described in this safety assessment. Octyl isobutyrate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog hexyl isobutyrate (CAS # 2349-07-7) show that octyl isobutyrate is

Kränkning och upprättelse. En replikation av en rättssociologisk enkätstudie om kränkningsersättning till brottsoffer. Konferensabstract.

Presentation av ett rättssociologiskt forskningsprojekt som replikerar en rättssociologisk undersökning om det allmänna rättsmedvetandet och brottsskadeersättningen. Att projektet är en ”replika” innebär att syftet har varit att göra en uppföljning av ett ursprungligt forskningsprojekt som i det aktuella fallet utgörs av de enkätundersökningar som presterades i avhandlingen ”Kränkning och upprätte

Unsupervised cluster analysis and subset characterization of abnormal erythropoiesis using the bioinformatic Flow-Self Organizing Maps algorithm

BACKGROUND: The Flow-Self Organizing Maps (FlowSOM) artificial intelligence (AI) program, available within the Bioconductor open-source R-project, allows for an unsupervised visualization and interpretation of multiparameter flow cytometry (MFC) data.METHODS: Applied to a reference merged file from 11 normal bone marrows (BM) analyzed with an MFC panel targeting erythropoiesis, FlowSOM allowed to

European Society of Cardiology methodology for the development of quality indicators for the quantification of cardiovascular care and outcomes

Aims: It is increasingly recognized that tools are required for assessing and benchmarking quality of care in order to improve it. The European Society of Cardiology (ESC) is developing a suite of quality indicators (QIs) to evaluate cardiovascular care and support the delivery of evidence-based care. This paper describes the methodology used for their development. Methods and results: We propose